The Relation of Arterial Stiffness with Vascular Calcification and BMD in Chronic Kidney Disease

Shin, Young Shin; Shin, Mi Jung; Song, Ho Cheol; Kim, Dae Bum; Kim, Young Soo; Kim, Byung Soo; Kim, Young Ok; Kim, Yong Soo

Abstract

PURPOSE
Vascular calcification with arterial stiffness as well as bone mineral density was compared in hemodialysis, peritoneal dialysis patients, and pre-dialysis patients.
METHODS
The calcification level of the aorta was scored, the arterial stiffness level was examined by pulse wave velocity (PWV), and bone mineral density was measured by the use of DEXA, and analyzed.
RESULTS
PWV was significantly higher in the calcification group. The systolic blood pressure and the PWV value of the HD group was r=0.566 (p<0.001), the PD group was r=0.711 (p<0.001), and the pre-dialysis patients group was r=0.461 (p=0.001), and in all groups, a high correlation was shown. In the association of the PWV value with BMD and T score, in the PD patient group, with spine BMD, it was r=-0.351 (p<0.05), femur BMD was r=-0.510 (p<0.01), and femur T score was r=-0.527 (p= 0.001). In the multivariate analysis of the PWV value, in the HD group, age and systolic blood pressure were significant and in the PD group, calcification score femur BMD, femur T score, and CRP were significant factors. In the pre-dialysis patients group, only femur T score was detected to be a significant factor for PWV.
CONCLUSION
In hemodialysis patients, age and systolic blood pressure, and in peritoneal dialysis patients, vascular calcification and the BMD level were analyzed to be significant factors mediating effects on arterial stiffness.