- CKD-581 Downregulates Wnt/β-Catenin Pathway by DACT3 Induction in Hematologic Malignancy
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Kim SJ, Kim S, Choi YJ, Kim UJ, Kang KW
- KMID: 2532876
- Biomol Ther.
- 2022 Sep;30(5):435-446.
- doi: 10.4062/biomolther.2022.022
The present study evaluated the anti-cancer activity of histone deacetylase (HDAC)-inhibiting CKD-581 in multiple myeloma (MM) and its pharmacological mechanisms. CKD-581 potently inhibited a broad spectrum of HDAC isozymes. It... -
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- The KoreaN Cohort Study for Outcomes in Patients With Chronic Kidney Disease (KNOW-CKD): A Korean Chronic Kidney Disease Cohort
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Oh KH, Park SK, Kim J, Ahn C, Representing the KNOW-CKD Study Investigators
- KMID: 2532141
- J Prev Med Public Health.
- 2022 Jul;55(4):313-320.
- doi: 10.3961/jpmph.22.031
The KoreaN Cohort Study for Outcomes in Patients With Chronic Kidney Disease (KNOW-CKD) was launched in 2011 with the support of the Korea Disease Control and Prevention Agency. The study... -
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- Disease predictability review using common biomarkers appearing in diabetic nephropathy and neurodegeneration of experimental animals
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Yi SS
- KMID: 2527817
- Lab Anim Res.
- 2022 Mar;38(1):1-5.
- doi: 10.1186/s42826-022-00113-8
It is recently known that the kidney and brain have a very rich distribution of blood vessels, and the histological structures of micro-vessels are very similar. Therefore, a number of... -
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- A Long Way from Transfer to Transition: Challenges for Pediatric and Adult Nephrologists
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Lemke J, Pape L, Oh J
- KMID: 2435348
- Child Kidney Dis.
- 2018 Apr;22(1):7-11.
- doi: 10.3339/jkspn.2018.22.1.7
Significant advances in the diagnosis and medical care of children with chronic kidney disease (CKD) are major reasons for the better survival rates of children and adolescents with CKD than... -
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- Knowledge, attitudes and practices of hypertensive patients towards prevention and early detection of chronic kidney disease: a cross sectional study from Palestine
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Sa'adeh HH, Darwazeh R, Khalil AA, Zyoud SH
- KMID: 2434260
- Clin Hypertens.
- 2018 ;24(1):6.
- doi: 10.1186/s40885-018-0091-7
BACKGROUND: Hypertension is the second most common cause of chronic kidney disease (CKD). Therefore, the aims of the study were to assess the knowledge, attitudes and practices (KAP) of hypertensive... -
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- Baseline Cardiovascular Characteristics of Adult Patients with Chronic Kidney Disease from the KoreaN Cohort Study for Outcomes in Patients With Chronic Kidney Disease (KNOW-CKD)
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Kim H, Yoo TH, Choi KH, Oh KH, Lee J, Kim SW, Kim TH, Sung S, Han SH, KNOW-CKD Group
- KMID: 2364166
- J Korean Med Sci.
- 2017 Feb;32(2):231-239.
- doi: 10.3346/jkms.2017.32.2.231
Cardiovascular disease (CVD) is the most common cause of death in patients with chronic kidney disease (CKD). We report the baseline cardiovascular characteristics of 2,238 participants by using the data... -
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- Comparing Results of Five Glomerular Filtration Rate-Estimating Equations in the Korean General Population: MDRD Study, Revised Lund-Malmö, and Three CKD-EPI Equations
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Ji M, Lee YH, Hur M, Kim H, Cho HI, Yang HS, Navarin S, Di Somma S, GREAT Network
- KMID: 2373589
- Ann Lab Med.
- 2016 Nov;36(6):521-528.
- doi: 10.3343/alm.2016.36.6.521
BACKGROUND: Estimated glomerular filtration rate (eGFR) is a widely used index of kidney function. Recently, new formulas such as the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations or the Lund-Malmö... -
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- Phase I Study of CKD-516, a Novel Vascular Disrupting Agent, in Patients with Advanced Solid Tumors
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Oh DY, Kim TM, Han SW, Shin DY, Lee YG, Lee KW, Kim JH, Kim TY, Jang IJ, Lee JS, Bang YJ
- KMID: 2152257
- Cancer Res Treat.
- 2016 Jan;48(1):28-36.
- doi: 10.4143/crt.2014.258
PURPOSE: CKD-516 is a newly developed vascular disrupting agent. This phase I dose-escalation study of CKD-516 was conducted to determine maximum-tolerated dose (MTD), safety, pharmacokinetics, and preliminary antitumor efficacy in... -
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- Acute Kidney Injury and Chronic Kidney Disease as Interconnected Syndromes
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Lee SY
- KMID: 2269121
- Korean J Med.
- 2015 Apr;88(4):382-386.
- doi: 10.3904/kjm.2015.88.4.382
Although it was thought that survivors from an acute kidney injury (AKI) recovered kidney function completely, cumulative observational data have shown that AKI can cause end-stage renal disease directly, increase... -
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- Chronic Kidney Disease-mineral Bone Disorder and Active Vitamin D Analogs for Treating Severe Hyperparathyroidism in Children Receiving Chronic Peritoneal Dialysis
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Kang EG, Lee JH, Park YS
- KMID: 1733217
- J Korean Soc Pediatr Nephrol.
- 2014 Oct;18(2):64-70.
- doi: 10.3339/jkspn.2014.18.2.64
PURPOSE: The aims of this study were to assess the clinical and laboratory profiles of chronic kidney disease-mineral bone disorder (CKD-MBD) and to assess the effects of treatment of active... -
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- Early quantification of the therapeutic efficacy of the vascular disrupting agent, CKD-516, using dynamic contrast-enhanced ultrasonography in rabbit VX2 liver tumors
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Joo I, Kim JH, Lee JM, Choi JW, Han JK, Choi BI
- KMID: 2049893
- Ultrasonography.
- 2014 Jan;33(1):18-25.
PURPOSE: To evaluate the usefulness of dynamic contrast-enhanced ultrasonography (DCE-US) in the early quantification of hemodynamic change following administration of the vascular disrupting agent (VDA) CKD-516 using a rabbit VX2... -
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- Histopathological Evaluation of Heart Toxicity of a Novel Selective PPAR-gamma Agonists CKD-501 in db/db Mice
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Yang HI, Kim WS, Kim DH, Kang JS
- KMID: 2170691
- Biomol Ther.
- 2013 Jan;21(1):84-88.
High risk of cardiovascular diseases caused by existing PPAR-gamma agonists such as rosiglitazone and pioglitazone has been recently reported. CKD-501 is a novel selective PPAR-gamma agonist as a potential target... -
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- CKD-712, (S)-1-(alpha-naphthylmethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, Inhibits the NF-kappaB Activation and Augments Akt Activation during TLR4 Signaling
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Lee J, Yang EJ, Shin JS, Kim DH, Lee SS, Choi IH
- KMID: 2150730
- Immune Netw.
- 2011 Dec;11(6):420-423.
- doi: 10.4110/in.2011.11.6.420
Since CKD-712 has been developed as an anti-inflammatory agent, we examined the effect of CKD-712 during TLR4 signaling. Using HEK293 cells expressing TLR4, CKD-712 was pre-treated 1 hr before LPS... -
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- The Relation of Arterial Stiffness with Vascular Calcification and BMD in Chronic Kidney Disease
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Shin YS, Shin MJ, Song HC, Kim DB, Kim YS, Kim BS, Kim YO, Kim YS
- KMID: 2253162
- Korean J Nephrol.
- 2009 Sep;28(5):433-443.
PURPOSE:Vascular calcification with arterial stiffness as well as bone mineral density was compared in hemodialysis, peritoneal dialysis patients, and pre-dialysis patients. METHODS:The calcification level of the aorta was scored, the arterial... -
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- Research Related to Chronic Kidney Disease in BMI >25 Overweight Children
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Choi AR, Park SS, Kim SD, Cho BS
- KMID: 2197132
- J Korean Soc Pediatr Nephrol.
- 2009 Apr;13(1):75-83.
PURPOSE: Chronic kidney disease (CKD) and obesity are the worldwide public health problem. Obesity is an already well-established risk factor for CKD. The objective of this study is to evaluate... -
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- Clinical benefits of serum BNP measurement in patients with chronic kidney disease
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Jun SH, Choi SJ, Kim JK, Hwang SD
- KMID: 2081128
- Korean J Med.
- 2005 Aug;69(2):135-143.
BACKGROUND: B-type natriuretic peptide (BNP) regulates excretion of water and sodium in the kidney, and serum levels of BNP are increased in the settings of decreased ventricular contractility and myocardial... -
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- Anticancer effect of CKD-602(belotecan, camtobell(R)) on the oral cancer cell lines
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Yun PY, Ok YJ, Myoung H, Lee JH, Kim MJ
- KMID: 2058808
- J Korean Assoc Oral Maxillofac Surg.
- 2005 Feb;31(1):7-12.
PURPOSE: CKD-602, a newly developed water-soluble campthotecin analogue, is a anticancer agent which act as a DNA topoisomerase I inhibitor. CKD-602 is known as more potent and tolerable agent. The... -
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- The Study of Anemia in Stable Chronic Kidney Disease Patients not Receiving Dialysis Treatment
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Kwen JH, Cho S, Kim SR
- KMID: 2079273
- Korean J Nephrol.
- 2003 Jan;22(1):63-72.
BACKGROUND: Early detection and treatment of chronic kidney disease (CKD) are important for inhibition of kidney disease progression and prevention of cardiovascular complications. Treatment of Anemia that is frequently accompanied... -
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