J Bacteriol Virol.  2016 Mar;46(1):44-46. 10.4167/jbv.2016.46.1.44.

Eosinophils and Type 2 Cytokine Signaling in Macrophages Support the Biogenesis of Cold-induced Beige Fat

• Jung Y

• KMID: 2168742
• DOI: http://doi.org/10.4167/jbv.2016.46.1.44

Abstract

Brown adipose generates heat via oxidation of fatty acids by a mitochondrial uncoupling protein 1 (UCP1)-dependent process. In addition, a subpopulation of cells within subcutaneous white adipose tissue, known as beige adipocytes, also plays a role in thermogenesis. The biogenesis of beige adipocytes is induced by thermogenic signals, such as chronic cold exposure. Recently, it has been reported that eosinophils, type 2 cytokines of IL-4/13, and alternatively activated macrophages control the thermogenic cycle of beige adipocytes. Alternatively, activated macrophages induce UCP1+ beige adipocytes through secretion of catecholamines. These results define the role of type 2 immune responses in the regulation of energy homeostasis.

Keyword

Brown adipose tissue; Beige fat; Thermogenesis; Eosinophil; Type 2 cytokine

MeSH Terms

Adipocytes
Adipose Tissue, Brown
Adipose Tissue, White
Organelle Biogenesis*
Catecholamines
Cytokines
Eosinophils*
Fatty Acids
Homeostasis
Hot Temperature
Macrophages*
Thermogenesis
Catecholamines
Cytokines
Fatty Acids