- Peroxisomal disorders
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Lee SY
- KMID: 2168072
- Hanyang Med Rev.
- 2005 Aug;25(3):42-48.
Peroxisomes are subcellular organells catalyzing a number of important functions in cellular metabolism. Their functions are mostly related to lipid metabolism. Genetic disorders of peroxisomes are divided into 2 categories:... -
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- Insulin Resistance and Intracellular Thyroid Hormone Dysfunction
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Kim EY
- KMID: 2322004
- J Korean Soc Pediatr Endocrinol.
- 2009 Dec;14(2):94-99.
Insulin resistance and diabetes combine to impair mitochondrial oxidative metabolism and cause lipid accumulation in non-adipose tissues such as skeletal muscles and the liver. The thyroid hormone stimulates thermogenesis, mitochondrial... -
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- Eosinophils and Type 2 Cytokine Signaling in Macrophages Support the Biogenesis of Cold-induced Beige Fat
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Jung Y
- KMID: 2168742
- J Bacteriol Virol.
- 2016 Mar;46(1):44-46.
- doi: 10.4167/jbv.2016.46.1.44
Brown adipose generates heat via oxidation of fatty acids by a mitochondrial uncoupling protein 1 (UCP1)-dependent process. In addition, a subpopulation of cells within subcutaneous white adipose tissue, known as... -
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- Role of LAMMER Kinase in Cell Wall Biogenesis during Vegetative Growth of Aspergillus nidulans
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Choi YK, Kang EH, Park HM
- KMID: 2408978
- Mycobiology.
- 2014 Dec;42(4):422-426.
- doi: 10.5941/MYCO.2014.42.4.422
Depending on the acquisition of developmental competence, the expression of genes for beta-1,3-glucan synthase and chitin synthase was affected in different ways by Aspergillus nidulans LAMMER kinase. LAMMER kinase deletion,... -
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- Promise of Neurorestoration and Mitochondrial Biogenesis in Parkinson's Disease with Multi Target Drugs: An Alternative to Stem Cell Therapy
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Youdim MB, Oh YJ
- KMID: 2165480
- Exp Neurobiol.
- 2013 Sep;22(3):167-172.
- doi: 10.5607/en.2013.22.3.167
There is an unmet need in progressive neurodegenerative diseases such as Parkinson's and Alzheimer's diseases. The present therapeutics for these diseases at best is symptomatic and is not able to... -
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- Mitochondrial Homeostasis Molecules: Regulation by a Trio of Recessive Parkinson's Disease Genes
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Han JY, Kim JS, Son JH
- KMID: 2165539
- Exp Neurobiol.
- 2014 Dec;23(4):345-351.
- doi: 10.5607/en.2014.23.4.345
Mitochondria are small organelles that produce the majority of cellular energy as ATP. Mitochondrial dysfunction has been implicated in the pathogenesis of Parkinson's disease (PD), and rare familial forms of... -
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- Glucagon-Like Peptide-1 Increases Mitochondrial Biogenesis and Function in INS-1 Rat Insulinoma Cells
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Kang MY, Oh TJ, Cho YM
- KMID: 2282013
- Endocrinol Metab.
- 2015 Jun;30(2):216-220.
- doi: 10.3803/EnM.2015.30.2.216
Glucagon-like peptide-1 (GLP-1) is a gut-derived incretin hormone that increases glucose-stimulated insulin secretion in pancreatic beta-cells. Since mitochondrial function is crucial to insulin secretion, we hypothesized that GLP-1 may increase... -
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- Small Non-coding Transfer RNA-Derived RNA Fragments (tRFs): Their Biogenesis, Function and Implication in Human Diseases
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Fu Y, Lee I, Lee YS, Bao X
- KMID: 2166523
- Genomics Inform.
- 2015 Dec;13(4):94-101.
- doi: 10.5808/GI.2015.13.4.94
tRNA-derived RNA fragments (tRFs) are an emerging class of non-coding RNAs (ncRNAs). A growing number of reports have shown that tRFs are not random degradation products but are functional ncRNAs... -
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- Cellular NAD⺠Level: A Key Determinant of Mitochondrial Quality and Health
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Hwang ES, Hwang SY
- KMID: 2401128
- Ann Geriatr Med Res.
- 2017 Dec;21(4):149-157.
- doi: 10.4235/agmr.2017.21.4.149
The quality of mitochondria is a key determinant of mitochondrial ATP production and reactive oxygen species generation; therefore, it plays critical roles in energy homeostasis and cellular health. Mitochondrial quality... -
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- AMPK and Exercise: Glucose Uptake and Insulin Sensitivity
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O'Neill HM
- KMID: 2280737
- Diabetes Metab J.
- 2013 Feb;37(1):1-21.
- doi: 10.4093/dmj.2013.37.1.1
AMPK is an evolutionary conserved sensor of cellular energy status that is activated during exercise. Pharmacological activation of AMPK promotes glucose uptake, fatty acid oxidation, mitochondrial biogenesis, and insulin sensitivity;... -
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- Rescue of Heart Failure by Mitochondrial Recovery
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Marquez J, Lee SR, Kim N, Han J
- KMID: 2173121
- Int Neurourol J.
- 2016 Mar;20(1):5-12.
- doi: 10.5213/inj.1632570.285
Heart failure (HF) is a multifactorial disease brought about by numerous, and oftentimes complex, etiological mechanisms. Although well studied, HF continues to affect millions of people worldwide and current treatments... -
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- A Case of Neonatal Adrenoleukodystrophy Presented with Neonatal Seizure
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Choi J, You SJ, Ko TS, Kim EA, Kim KS, Pi SY, Yoo HW
- KMID: 2177020
- J Korean Child Neurol Soc.
- 2005 May;13(1):99-103.
Neonatal adrenoleukodystrophy(NALD) is an inherited autosomal recessive disease characterized by very early onset of neurologic deterioration, extreme hypotonia, poor sucking reflex, failure to thrive, poor or absent grasp and Moro... -
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- Roles of Outer Membrane Vesicles (OMVs) in Bacterial Virulence
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Lim S, Yoon H
- KMID: 2168698
- J Bacteriol Virol.
- 2015 Mar;45(1):1-10.
- doi: 10.4167/jbv.2015.45.1.1
Outer membrane vesicles (OMVs) are ubiquitous membranous structures in all Gram-negative bacteria, including pathogens and non-pathogens. Gram-positive bacteria also release membrane-derived vesicles (MV). Originating from the cell envelope, OMVs are... -
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- Effects of intermittent ladder-climbing exercise training on mitochondrial biogenesis and endoplasmic reticulum stress of the cardiac muscle in obese middle-aged rats
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Kim K, Ahn N, Jung S, Park S
- KMID: 2395258
- Korean J Physiol Pharmacol.
- 2017 Nov;21(6):633-641.
- doi: 10.4196/kjpp.2017.21.6.633
The aim of this study is to investigate the effects of intermittent ladder-climbing exercise training on mitochondrial biogenesis and ER stress of the cardiac muscle in high fat diet-induced obese... -
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- Deletion of GBG1/AYR1 Alters Cell Wall Biogenesis in Saccharomyces cerevisiae
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Ahn KW, Kim SW, Kang HG, Kim KH, Park YH, Choi WJ, Park HM
- KMID: 2312574
- Mycobiology.
- 2010 Jun;38(2):102-107.
We identified a gene for beta-1,3-glucan synthesis (GBG1), a nonessential gene whose disruption alters cell wall synthesis enzyme activities and cell wall composition. This gene was cloned by functional complementation... -
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- Exercise and Mitochondrial Remodeling in Skeletal Muscle in Type 2 Diabetes
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Lee H, Song W
- KMID: 2436604
- J Obes Metab Syndr.
- 2018 Sep;27(3):150-157.
- doi: 10.7570/jomes.2018.27.3.150
Exercise is regarded as a potent stimulus in modulation of glucose utility and mitochondrial adaptations in skeletal muscle, leading to enhanced metabolic health. As mitochondria play a crucial role in... -
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- A Case of Ehlers-Danlos Syndrome Accompanied by Mitral Valvular Prolapse and Atrial Septal Defect
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Kim JW, Jung IS, Lim KS, Choi YM, Choi JC, Ohk JH, Shu DR
- KMID: 2229378
- Korean Circ J.
- 1990 Jun;20(2):265-270.
- doi: 10.4070/kcj.1990.20.2.265
Ehlers-Danlos Syndrome(EDS) is an inherited disorder of the connective tissue disease that is usually transmitted as autosomal dominant trait. The defect in the biogenesis of collagen results in varying degree... -
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- Skeletal Muscle Glycogen Breakdown According to Duration of Endurance Training
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Kim SH
- KMID: 2382046
- Korean J Sports Med.
- 2016 Dec;34(2):101-106.
- doi: 10.5763/kjsm.2016.34.2.101
Endurance exercise training such as marathon can increase the ability of exercise performance. Muscle glycogen is associated with an exercise performance, because glycogen depletion is primary causes of muscle fatigue.... -
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- Pathogenesis of Ankylosing Spondylitis
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Kim HW, Lee SH
- KMID: 2222907
- J Rheum Dis.
- 2015 Apr;22(2):61-68.
- doi: 10.4078/jrd.2015.22.2.61
Ankylosing spondylitis (AS) is the prototype of spondyloarthritis which shares complex clinical phenotypes and risk factors, both genetic and environmental with other chronic inflammatory disease, e.g. inflammatory bowel disease. Human... -
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- Effects of dietary leucine supplementation on the hepatic mitochondrial biogenesis and energy metabolism in normal birth weight and intrauterine growth-retarded weanling piglets
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Su W, Xu W, Zhang H, Ying Z, Zhou L, Zhang L, Wang T
- KMID: 2412024
- Nutr Res Pract.
- 2017 Apr;11(2):121-129.
- doi: 10.4162/nrp.2017.11.2.121
BACKGROUND/OBJECTIVES: The study was conducted to evaluate the effects of dietary leucine supplementation on mitochondrial biogenesis and energy metabolism in the liver of normal birth weight (NBW) and intrauterine growth-retarded... -
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