Korean J Anesthesiol.  1996 Nov;31(5):588-593. 10.4097/kjae.1996.31.5.588.

The Effect of Different Dosage of Propofol on Cardiovascular Responses to Tracheal Intubation in Hypertensive Patients

• Choi YS
• Lee WG
• Oh IY
• Son JY
• Lee MK
• Lim SH
• Yoon SM

• KMID: 2091020
• DOI: http://doi.org/10.4097/kjae.1996.31.5.588

Abstract

BACKGROUND: Laryngoscopy and endotracheal intubation are potent stimuli that increase heart rate and blood pressure. Especially, hypertensive patients are more prone to have significant increase in heart rate and blood pressure and cardiac complications such as arrythmia, myocardial ischemia and infarction can lead to fatal situation. This study was designed to evaluate the effectiveness of different dosage of propofol on cardiovascular responses to tracheal intubation in hypertensive patients.
METHODS
Sixty hypertensive patients, ASA PS 1 or 2, scheduled for elective surgery were selected randomly. They were divided into three groups(Group 1: propofol 2.0 mg/kg, Group 2: propofol 2.5 mg/kg, Group 3: propofol 3.0 mg/kg, n=20 in each group). Induction of Anesthesia was started with propofol 2.0 mg/kg(Group 1), 2.5 mg/kg(Group 2), 3.0 mg/kg(Group 3) and succinylcholine(1 mg/kg). After tracheal intubation, pancuronium bromide 0.08 mg/kg was injected, 50 % nitrous oxide in oxygen and 2 % enflurane were inhaled. Using noninvasive automatic blood pressure monitor(CRITIKON DINAMAP TM 1846SX, USA), blood pressure(systolic, diastolic, and mean arterial pressure) and heart rate were measured at 4 points; 1) as the control value, on arrival to operating room, 2) 1 minute after tracheal intubation, 3) 3 minutes after intubation, 4) 5 minutes after intubation.
RESULTS
In group 3, systolic, diastolic pressure and mean arterial pressure at 1 minutes, 3 minutes, 5 minutes after intubation were less increased than group 1, 2 and blood pressure response was more effectively blunted than heart rate response
CONCLUSIONS
we suggested that 3.0 mg/kg of propofol for the induction of anesthesia could blunt hemodynamic changes caused by laryngoscopy and endotracheal intubation in hypertensive patients, but we had to give attention to the side effect until postoperative period.

Keyword

Anesthetics; intravenous Propofol; Anesthetic techniques endotracheal intubation; Blood pressure; Heart heart rate

MeSH Terms

Anesthesia
Anesthetics
Arrhythmias, Cardiac
Arterial Pressure
Blood Pressure
Enflurane
Heart Rate
Hemodynamics
Humans
Infarction
Intubation*
Intubation, Intratracheal
Laryngoscopy
Myocardial Ischemia
Nitrous Oxide
Operating Rooms
Oxygen
Pancuronium
Postoperative Period
Propofol*
Anesthetics
Enflurane
Nitrous Oxide
Oxygen
Pancuronium
Propofol