Effects of Propofol Administration on Cardiovascular Changes of Tracheal Intubation

Kim, Su Mi; Lee, Guie Yong; Lee, Choon Hi

Abstract

A new intravenous anesthetic agent, propofol reduces arterial blool pressure and reduces cardiovascular changes of tracheal intubation. The purpose of this study is to evaluate the effects of administration of thiopental 5 mg/kg and propofol 2.5 mg/kg on cardiovascular changes of tracheal intubation. Systolic arterial presure, diastolic arterial pressure, mean arterial pressure, heart rate and rate-pressure product were determined in healthy patients seheduled for tracehal intubation for general anesthesia before induction, after induction, 1, 3, and 5 minute after tracheal intubation. 1) After induction of anesthesia, above cardiovascular measurements except heart rate decreased significantly in both groups, but more profoundly in the propofol group. Heart rate did not change significantly in both groups. 2) Systolic arterial pressure, diastolic arterial pressure and mean arterial pressure increased significantly in the thiopental group after tracheal intubation, but decreased significantly in the thiopental group after tracehal intubation, but decreased significantly in the propofol group. After tracheal intubation, heart rate and rate-pressure product increased significantly in both groups, but the propofol group returned to the control value faster than the thiopental groups. In conclusion, in healthy adult patients, rise in the arterial blood pressure and heart rate after tracheal intubation decreased significantly in the propofol group compared with the thiopental group.