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External Validation of a Pharmacokinetic Model of Propofol for Target-Controlled Infusion in Children under Two Years Old

Ji SH, Lee JH, Cho JY, Kim HS, Jang YE, Kim EH, Kim JT, Kim HS

BACKGROUND: Previously, a linked pharmacokinetic-pharmacodynamic model (the Kim model) of propofol with concurrent infusion of remifentanil was developed for children aged 2–12 years. There are few options for pharmacokinetic-pharmacodynamic model...
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Easy sedation anesthesia guide for non-anesthetic medical personnel

Min TJ

Currently, sedation anesthesia is increasingly used in many medical fields, from gastroscopy to medical imaging. The demand for sedation anesthesia is expected to increase gradually with increasing number of day...
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Medium- and long-chain triglyceride propofol reduces the activity of acetyl-coenzyme A carboxylase in hepatic lipid metabolism in HepG2 and Huh7 cells

Wang LY, Wu J, Gao YF, Lin DM, Ma J

Medium- and long-chain triglyceride (MCT/LCT) propofol is widely used as an intravenous anesthetic, especially in the intensive care unit. The present study aimed to assess whether MCT/LCT propofol is safe...
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Assessment of phase-lag entropy, a new measure of electroencephalographic signals, for propofol-induced sedation

Jun MR, Yoo JH, Park SY, Na S, Kwon H, Nho JH, Kim SI

BACKGROUND: Phase-lag entropy (PLE) was recently described as a measurement of temporal pattern diversity in the phase relationship between two electroencephalographic signals from prefrontal and frontal montages. This study was...
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Anesthetic management in corticobasal degeneration with central sleep apnea: A case report

Shionoya Y, Nakamura K, Sunada K

Corticobasal degeneration (CBD) is a rare neurodegenerative disease characterized by dystonia, cognitive deficits, and an asymmetric akinetic-rigid syndrome. Little information is available regarding anesthetic management for CBD patients. Our patient...
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Effects site concentrations of propofol using target-controlled infusion in dental treatment under deep sedation among different intellectual disability types

Salinas Salmeron KS, Kim HJ, Seo KS

BACKGROUND: We aimed to assess the dose needed to achieve the propofol effect-site concentration using target-controlled infusion in intellectually disabled patients and to detail the most effective method for achieving...
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The change of stroke volume variation during thoracotomy or one lung ventilation

Lim H, Kim DC, Kim MJ, Yoo S, Ki MJ, Kang S, Kim D

BACKGROUND: Stroke volume variation (SVV) is based on cyclic changes of intrathoracic pressure during respiratory cycle. Thoracotomy and one-lung ventilation (OLV) can lead to changes in airway and intrathoracic pressure....
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The Author's Response: Evaluation of Propofol in Comparison with Other General Anesthetics for Surgery in Children Younger than 3 Years: a Systematic Review and Meta-Analysis

Hong H, Hahn S, Choi Y, Jang MJ, Kim S, Lee JH, Kim HS

No abstract available.
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Letter to the Editor: Is Propofol Good Choice for Procedural Sedation? Evaluation of Propofol in Comparison with Other General Anesthetics for Surgery in Children Younger than 3 Years

Kim SC

No abstract available.
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Anesthetic considerations during surgical intervention in Woake's syndrome: a case report

Choi SR, Kim JH, Chae KL, Lee SC, Park SY

BACKGROUND: Woake's syndrome (WS) is a recurrent nasal polyposis, accompanied by broadening of the nose, frontal sinus aplasia, dyscrinia, and bronchiectasis. There has been no previous report on anesthetic management...
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Three minutes propofol after sevoflurane anesthesia to prevent emergence agitation following inguinal hernia repair in children: a randomized controlled trial

Abbas MS, El-Hakeem , Kamel HE

BACKGROUND: Emergence agitation (EA) is a common problem after sevoflurane anesthesia among children. There have been mixed results with control of EA using propofol 1 mg/kg bolus following sevoflurane anesthesia....
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Severe Anaphylaxis without Key Signs Such as Urticaria and Bronchospasm Suspected to Be Induced by Rocuronium

Kim AJ, Chun HR

Perioperative hypersensitivity reaction have been reported to have a variable degree of the incidence from differ countries and to be 1/353–18,600 approximately and its mortality has been reported to be...
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Propofol Suppresses LPS-Induced Inflammation in Amnion Cells via Inhibition of NF-κB Activation

Yoon JY, Kim DW, Ahn JH, Choi EJ, Kim YH, Jeun M, Kim EJ

BACKGROUND: Preterm labor is a leading risk factor for neonatal death and long-term impairment and linked closely with inflammation. Non-obstetric surgery is occasionally needed during pregnancy and the anesthetic drugs...
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Comparative Analysis of Phase Lag Entropy and Bispectral Index as Anesthetic Depth Indicators in Patients Undergoing Thyroid Surgery with Nerve Integrity Monitoring

Seo KH, Kim KM, Lee SK, John H, Lee J

BACKGROUND: Most depth of anesthesia (DOA) monitors rely on the temporal characteristics of a single-channel electroencephalogram (EEG) and cannot provide spatial or connectivity information. Phase lag entropy (PLE) reflects DOA...
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Propofol with and without Midazolam for Diagnostic Upper Gastrointestinal Endoscopies in Children

Akbulut UE, Kartal S, Dogan U, Akcali GE, Kalayci S, Kirci H

PURPOSE: Various publications on the use of sedation and anesthesia for diagnostic procedures in children have demonstrated that no ideal agent is available. Although propofol has been widely used for...
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Dexmedetomidine and propofol sedation requirements in an autistic rat model

Elmorsy SA, Soliman GF, Rashed LA, Elgendy H

BACKGROUND: Autism is a challenging neurodevelopmental disorder. Previous clinical observations have suggested altered sedation requirements for children with autism. Our study aimed to test this observation experimentally in an animal...
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Pharmacodynamic Analysis of the Influence of Propofol on Left Ventricular Long-Axis Systolic Performance in Cardiac Surgical Patients

Bang JY, Kim S, Choi BM, Kim TY

BACKGROUND: Propofol induced a decline in the left ventricular (LV) systolic performance in non-cardiac surgery. We tested the hypothesis that propofol decreased the LV contractile function by dose dependent manner...
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Evaluation of Propofol in Comparison with Other General Anesthetics for Surgery in Children Younger than 3 Years: a Systematic Review and Meta-Analysis

Hong H, Hahn S, Choi Y, Jang MJ, Kim S, Lee JH, Kim HS

BACKGROUND: Despite well-known advantages, propofol remains off-label in many countries for general anesthesia in children under 3 years of age due to insufficient evidence regarding its use in this population....
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Adaptive smith predictor controller for total intravenous anesthesia automation

Patel B, Patel H, Vachhrajani P, Shah D, Sarvaia A

Anesthetic agent propofol needs to be administered at an appropriate rate to prevent hypotension and postoperative adverse reactions. To comprehend more suitable anesthetic drug rate during surgery is a crucial...
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Increased Effect-Site Concentration of Propofol Reduces ECâ‚…â‚€ of Remifentanil for Successful Intubation Using the Shikani Optical Stylet without Neuromuscular Blockade

Cho SY, Lee CW, Park HJ, Park SH, Jeon WJ

OBJECTIVE: For short-duration surgery, propofol and remifentanil are the drugs of choice for intubation without neuromuscular blockade. The Shikani Optical Stylet (SOS) is a novel semi-rigid type fiberoptic laryngoscope. In...
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