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High-Flow Nasal Cannula Oxygen Therapy Can Be Effective for Patients in Acute Hypoxemic Respiratory Failure with Hypercapnia: a Retrospective, Propensity Score-Matched Cohort Study

Bae S, Han M, Kim C, Lee H, Ahn JJ, Kim JH, Kang BJ

BACKGROUND: Usually, high-flow nasal cannula (HFNC) therapy is indicated for de novo acute hypoxemic respiratory failure (AHRF). Although only a few researches have examined the effectiveness of HFNC therapy for...
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Inhibition of melanogenesis by sodium 2-mercaptoethanesulfonate

Kim JH, Oh CT, Kwon TR, Kim JH, Bak DH, Kim H, Park WS, Kim BJ

Sodium 2-mercaptoethanesulfonate (mesna) is a protective agent that is widely used in medicine because of its antioxidant effects. Recently, reactive oxygen species (ROS) were shown to increase pigmentation. Thus, ROS...
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Mitochondrial Mechanisms in Diabetic Cardiomyopathy

Gollmer J, Zirlik A, Bugger H

Mitochondrial medicine is increasingly discussed as a promising therapeutic approach, given that mitochondrial defects are thought to contribute to many prevalent diseases and their complications. In individuals with diabetes mellitus...
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Current Situation of Home Oxygen Therapy for Chronic Obstructive Pulmonary Disease Patients in Korea

Kim JK, Jang SH, Park S, Kim JH, Park JY, Yoo KH, Kim YS, Lim SY, Hwang YI

BACKGROUND: Long-term oxygen therapy provides various benefits, including prolonged survival for severely hypoxic chronic obstructive pulmonary disease (COPD) patients. However, adequate management strategies for home oxygen therapy are not well...
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Neuroprotective effects of urolithin A on Hâ‚‚Oâ‚‚-induced oxidative stress-mediated apoptosis in SK-N-MC cells

Kim KB, Lee S, Kim JH

BACKGROUND/OBJECTIVES: Oxidative stress causes cell damage and death, which contribute to the pathogenesis of neurodegenerative diseases. Urolithin A (UA), a gut microbial-derived metabolite of ellagitannins and ellagic acid, has high...
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Gastric and rectal cancers in workers exposed to asbestos: a case series

Choi BJ, Lee S, Lee IJ, Park SW, Lee S

BACKGROUND: The Occupational Safety and Health Research Institute (OSHRI) of the Korea had not recognized gastrointestinal cancer as work-related disease during their evaluation. However, in 2018 OSHRI recognized gastric and...
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Curcumin Attenuates Acrolein-induced COX-2 Expression and Prostaglandin Production in Human Umbilical Vein Endothelial Cells

Lee SE, Park HR, Jeon S, Han D, Park YS

OBJECTIVE: Inflammation is crucial to limiting vascular disease. Previously we reported that acrolein, a known toxin in tobacco smoke, might play an important role in the progression of atherosclerosis via...
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The biofilm removal effect of MnOâ‚‚-diatom microbubbler from the dental prosthetic surfaces: In vitro study

Lee EH, Seo Y, Kwon HB, Yim YJ, Kong H, Kim MJ

PURPOSE: The aim of this study is to evaluate the effectiveness of MnOâ‚‚-diatom microbubbler (DM) on the surface of prosthetic materials as a mouthwash by comparing the biofilm removal effect...
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Comparison of the trometamol-balanced solution with two other crystalloid solutions for fluid resuscitation of a rat hemorrhagic model

Ting WT, Chang RW, Wang CH, Chen YS, Lee JJ

Currently, the optimal resuscitation fluid remains debatable. Therefore, in the present study, we designed a trometamol-balanced solution (TBS) for use as a resuscitation fluid for hemorrhagic shock. Hemorrhagic shock was...
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Fluoxetine Induces Apoptotic and Oxidative Neuronal Death Associated with The Influx of Copper Ions in Cultured Neuronal Cells

Hwang S, Kim JK

We examined the effect of fluoxetine, a selective serotonin reuptake inhibitor antidepressant, on neuronal viability in mouse cortical near-pure neuronal cultures. Addition of fluoxetine to the media for 24 hours...
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Recompression for Spinal Cord Decompression Sickness: Onset Time and Treatment Protocol

Lee SH, Ahn JY

BACKGROUND: Symptoms of spinal cord decompression sickness (DCS) occur almost immediately after emerging from the water. It is recommended that recompression treatment be performed soon to decrease the bubble size...
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Oxygen supplementation via high-flow nasal cannula is an effective treatment for pneumocephalus

Lee DS, Cha JK, Lee DH, Byun KS, Jeong JH

BACKGROUND: Oxygen supplementation through a high-flow nasal cannula (HFNC) is a powerful technique that promotes the absorption of air by delivering high concentrations of oxygen to patients who are not...
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Effect of Obstructive Sleep Apnea on the Functional Outcome of Acute Ischemic Stroke

Han SH, Park KY, Kim YS, Kim JM, Lee SY

OBJECTIVES: This study investigated the prevalence and clinical characteristics of obstructive sleep apnea (OSA) in acute ischemic stroke patients and the effect of OSA on prognosis of acute ischemic stroke. METHODS:...
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A Preliminary Study for Effect of High Flow Oxygen through Nasal Cannula Therapy in Carbon Monoxide Poisoning

Kim YM, Kim SC, Park KJ, Lee SW, Lee JH, Kim H

PURPOSE: Acute carbon monoxide (CO) poisoning is one of the most common types of poisoning and a major health problem worldwide. Treatment options are limited to normobaric oxygen therapy, administered...
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PaCOâ‚‚ at Early Stage is Associated with Adverse Cardiovascular Events in Acute Carbon Monoxide Poisoning

Yang KM, Chun BJ, Moon JM, Cho YS

PURPOSE: The objective was to determine the association between PaCOâ‚‚ and adverse cardiovascular events (ACVEs) in carbon monoxide (CO)-poisoned patients. METHODS: This retrospective study included 194 self-breathing patients after CO poisoning...
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Anti-tumor activity and mitochondrial stability of disulfiram in HL-60 cells

Disulfiram (DSF) is a member of the dithiocarbamate family that can bind copper. Recent studies have shown that DSF has anti-cancer activities, but the mechanism has not been clarified. Therefore,...
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A Carbon Monoxide Poisoning Case in Which Hyperbaric Oxygen Therapy Was Not Possible Due to Iatrogenic Pneumothorax after Unnecessary Central Catheterization

Kim HI, Oh SB

Hyperbaric oxygen therapy (HBOT) is used to treat carbon monoxide (CO) poisoning. However, untreated pneumothorax is an absolute contraindication for HBOT. More caution is needed with regard to monoplace hyperbaric...
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Effects of dynamic oxygen concentrations on the development of mouse pre- and peri-implantation embryos using a double-channel gas supply incubator system

Lee SC, Seo HC, Lee J, Jun JH, Choi KW

OBJECTIVE: We aimed to evaluate the effects of different oxygen conditions (20% [high Oâ‚‚], 5% [low Oâ‚‚] and 5% decreased to 2% [dynamic Oâ‚‚]) on mouse pre- and peri-implantation development...
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Protective effects of D-005, a lipid extract from Acrocomia crispa fruits, against ischemia/reperfusion-induced acute kidney injury in rats

Oyarzábal-Yera A, Rodríguez-Salgueiro S, Merino-García N, Ocaña-Nápoles L, González-Núñez L, Mena-Valdés L, Zamora-Rodríguez Z, Medina-Pírez JA, Jiménez-Despaigne S, Molina-Cuevas V

BACKGROUND: Acute kidney injury (AKI) induced by renal ischemia/reperfusion (IR) is associated with enhanced production of reactive oxygen species in renal tissues. D-005, a lipid extract obtained from Acrocomia crispa...
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The role of oxidative stress and hypoxia in renal disease

Honda T, Hirakawa Y, Nangaku M

Oxygen is required to sustain aerobic organisms. Reactive oxygen species (ROS) are constantly released during mitochondrial oxygen consumption for energy production. Any imbalance between ROS production and its scavenger system...
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