Korean J Nephrol.
2005 Jul;24(4):526-536.
The Anti-inflammatory Effect of Rosiglitazone on Renal Injury in Sepsis Model
- Affiliations
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- 1Department of Internal Medicine, Chonbuk National University Medical School, Jeonju, South Korea. kidney@chonbuk.ac.kr
- 2Department of Pathology, Chonbuk National University Medical School, Jeonju, South Korea.
- 3Department of Preventive Medicine, Chonbuk National University Medical School, Jeonju, South Korea.
- 4Department of Obstetrics &S Gynecology, Chonbuk National University Medical School, Jeonju, South Korea.
- 5Department of Family Medicine, Che Cheon Seoul Hospital, Research Institute of Clinical Medicine, Jeonju, South Korea.
Abstract
- BACKGROUND
Agonists of the peroxisome proliferator-activated receptor gamma may help to regulate inflammation by modulating the production of inflammatory mediators and adhesion molecules. The purpose of this study was to determine the anti- inflammatory effects of rosiglitazone on renal injury in sepsis model. METHODS: In lipopolysaccharide (LPS)-induced mouse sepsis, we examined the effect of rosiglitazone on LPS-induced overproduction of inflammatory mediators, on the expression of adhesion molecules, on the infiltration of inflammatory cells and on renal function. RESULTS: Rosiglitazone significantly decreased serum tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta levels during sepsis. The levels of blood urea nitrogen and creatinine were significantly lower in mice pretreated with rosiglitazone than that in LPS-treated mice. Rosiglitazone reduced the expression of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in renal tissue of LPS-treated mice. Pretreatment with rosiglitazone reduced the infiltration of macrophages/ monocytes in renal tissue. CONCLUSION: These results indicate that pretreatment with rosiglitazone attenuated the production of TNF-alpha and IL-1beta and reduced adhesion molecule expression and infiltration of inflammatory cells in renal tissue of LPS-treated mice. Therefore, rosiglitazone may have a protective effect in maintaining renal function and reducing mortality and morbidity in sepsis.
Keyword
MeSH Terms
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Animals
Blood Urea Nitrogen
Creatinine
Inflammation
Intercellular Adhesion Molecule-1
Interleukins
Mice
Monocytes
Mortality
PPAR gamma
Sepsis*
Tumor Necrosis Factor-alpha
Vascular Cell Adhesion Molecule-1
Creatinine
Intercellular Adhesion Molecule-1
Interleukins
PPAR gamma
Tumor Necrosis Factor-alpha
Vascular Cell Adhesion Molecule-1
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