J Korean Diabetes Assoc.  2004 Apr;28(2):131-138.

Exercise and Fenofibrate Reduces Body Adiposity Synergistically in OLETF Rats

• An YJ
• Lee HJ
• Park MK
• Lee KI
• Koh IY
• Jung DS
• Kang AY
• Kim DK

Abstract

BACKGROUND: The PPAR alpha activator, Fenofibrate, is a pharmacological ligand, which induces beta-oxidation of long chain fatty acids in the mitochondria of hepatocytes. The beta-oxidation induced by exogenous PPAR alpha activators may be operated maximally when the sustained production of energy substrate in the liver is required by working muscles due to continued exercise. The aim of this study was to determine whether the combination therapy of exercise and Fenofibrate could synergistically reduce body adiposity in OLETF rats.
METHODS
Twenty-eight male OLETF rats(13 wk old) were divided into four groups. The diet(n=7) and exercise groups(n=7) were fed with chow for 12 weeks. The Fenofibrate(n=7) and combined treatment(exercise and Fenofibrate) groups (n=7) were fed with Fenofibrate(32mg/kg/day) mixed chow for 12 weeks. The animals in the exercise and combined treatment groups were exercised by running on a treadmill for 12 weeks. At 24 weeks of age, all the rats were sacrificed, and examined by biochemical tests and had their adipose tissue weight measured.
RESULTS
There were no significant changes in the retroperitoneal and subcutaneous fats between the diet and Fenofibrate groups, but there were between the diet and combined treatment groups(P<0.05).
CONCLUSION
Exercise combined with Fenofibrate synergistically reduces body adiposity in OLETF rats

Keyword

Exercise; Fenofibrate; Adiposity; PPAR alpha activator

MeSH Terms

Adipose Tissue
Adiposity*
Animals
Diet
Fatty Acids
Fenofibrate*
Hepatocytes
Humans
Liver
Male
Mitochondria
Muscles
PPAR alpha
Rats
Rats, Inbred OLETF*
Running
Subcutaneous Fat
Fatty Acids
Fenofibrate
PPAR alpha