- Successful Treatment of a Korean Infant with Giant Cell Hepatitis with Autoimmune Hemolytic Anemia Using Rituximab
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Kim YH, Kim JW, Lee EJ, Kang GH, Kang HJ, Moon JS, Ko JS
- KMID: 2471628
- Pediatr Gastroenterol Hepatol Nutr.
- 2020 Mar;23(2):180-187.
- doi: 10.5223/pghn.2020.23.2.180
Giant cell hepatitis with autoimmune hemolytic anemia (AHA) is a rare disease of infancy characterized by the presence of both Coombs-positive hemolytic anemia and progressive liver disease with giant cell... -
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- Hepatitis B vaccination and immunotherapies: an update
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Stasi C, Silvestri , Voller F
- KMID: 2470832
- Clin Exp Vaccine Res.
- 2020 Jan;9(1):1-7.
- doi: 10.7774/cevr.2020.9.1.1
World Health Organization (WHO) estimates that 257 million people were living with chronic hepatitis B virus (HBV) infection. Highest HBV prevalence was found in the WHO Western Pacific Region (6.2%)... -
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- Ceramides: Nutrient Signals that Drive Hepatosteatosis
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Summers SA
- KMID: 2470800
- J Lipid Atheroscler.
- 2020 Jan;9(1):50-65.
- doi: 10.12997/jla.2020.9.1.50
Ceramides are minor components of the hepatic lipidome that have major effects on liver function. These products of lipid and protein metabolism accumulate when the energy needs of the hepatocyte... -
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- Medium- and long-chain triglyceride propofol reduces the activity of acetyl-coenzyme A carboxylase in hepatic lipid metabolism in HepG2 and Huh7 cells
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Wang LY, Wu J, Gao YF, Lin DM, Ma J
- KMID: 2466566
- Korean J Physiol Pharmacol.
- 2020 Jan;24(1):19-26.
- doi: 10.4196/kjpp.2020.24.1.19
Medium- and long-chain triglyceride (MCT/LCT) propofol is widely used as an intravenous anesthetic, especially in the intensive care unit. The present study aimed to assess whether MCT/LCT propofol is safe... -
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- The Protective Effect of Green Tea Extract on Alpha-amanitin Induced Hepatotoxicity
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An SH, Sun KH, Hong R, Lee BR, Park Y
- KMID: 2470188
- J Korean Soc Clin Toxicol.
- 2019 Dec;17(2):58-65.
- doi: 10.22537/jksct.2019.17.2.58
PURPOSE: Alpha-amanitin induces potent oxidative stress and apoptosis, and may play a significant role in the pathogenesis of hepatotoxicity. This study examined the mechanisms of α-amanitin-induced apoptosis in vitro, and... -
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- Gadoxetic acid-enhanced magnetic resonance imaging: Hepatocellular carcinoma and mimickers
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Kim YY, Park MS, Aljoqiman , Choi JY, Kim MJ
- KMID: 2459784
- Clin Mol Hepatol.
- 2019 Sep;25(3):223-233.
- doi: 10.3350/cmh.2018.0107
Gadoxetic acid, a hepatocyte-specific magnetic resonance imaging (MRI) contrast agent, has emerged as an important tool for hepatocellular carcinoma (HCC) diagnosis. Gadoxetic acid-enhanced MRI is useful for the evaluation of... -
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- Progressive Familial Intrahepatic Cholestasis in Korea: A Clinicopathological Study of Five Patients
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Kang HJ, Hong SA, Oh SH, Kim KM, Yoo HW, Kim GH, Yu E
- KMID: 2454605
- J Pathol Transl Med.
- 2019 Jul;53(4):253-260.
- doi: 10.4132/jptm.2019.05.03
BACKGROUND: Progressive familial intrahepatic cholestasis (PFIC) is a heterogeneous group of autosomal recessive liver diseases that present as neonatal cholestasis. Little is known of this disease in Korea. METHODS: The records... -
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- Implication of hepatocyte dedifferentiation in pathogenesis and treatment of hepatocellular carcinoma
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Kim HS, Park EJ, Lee CW
- KMID: 2469527
- Precis Future Med.
- 2019 Jun;3(2):37-42.
- doi: 10.23838/pfm.2018.00135
Liver cancer is the fifth most common malignancy worldwide and the third most common cause of cancer-related death. Five hundred million individuals are infected by hepatitis B or C virus.... -
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- Understanding Bile Acid Signaling in Diabetes: From Pathophysiology to Therapeutic Targets
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Ferrell JM, Chiang JY
- KMID: 2454055
- Diabetes Metab J.
- 2019 Jun;43(3):257-272.
- doi: 10.4093/dmj.2019.0043
Diabetes and obesity have reached an epidemic status worldwide. Diabetes increases the risk for cardiovascular disease and non-alcoholic fatty liver disease. Primary bile acids are synthesized in hepatocytes and are... -
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- Curcumin modulates the apolipoprotein B mRNA editing by coordinating the expression of cytidine deamination to uridine editosome components in primary mouse hepatocytes
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He P, Tian N
- KMID: 2443606
- Korean J Physiol Pharmacol.
- 2019 May;23(3):181-189.
- doi: 10.4196/kjpp.2019.23.3.181
Curcumin, an active ingredient of Curcuma longa L., can reduce the concentration of low-density lipoproteins in plasma, in different ways. We had first reported that curcumin exhibits hypocholesterolemic properties by... -
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- Stem Cell-Based Therapies for Liver Diseases: An Overview and Update
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Wang J, Sun M, Liu W, Li Y, Li M
- KMID: 2449242
- Tissue Eng Regen Med.
- 2019 Apr;16(2):107-118.
- doi: 10.1007/s13770-019-00178-y
BACKGROUND: Liver disease is one of the top causes of death globally. Although liver transplantation is a very effective treatment strategy, the shortage of available donor organs, waiting list mortality,... -
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- Hepatic failure caused by acute fatty liver of pregnancy treated by orthotopic liver transplantation: A case report
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Bang YS, Ko D, Lee S, Lee S, Park C
- KMID: 2447969
- Anesth Pain Med.
- 2019 Apr;14(2):197-201.
- doi: 10.17085/apm.2019.14.2.197
Acute fatty liver of pregnancy (AFLP) is unusual but can potentially progress to overwhelming liver failure, resulting in maternal and fetal death. AFLP is characterized by the accumulation of microvesicular... -
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- Nicotinamide riboside regulates inflammation and mitochondrial markers in AML12 hepatocytes
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Lee HJ, Yang SJ
- KMID: 2434070
- Nutr Res Pract.
- 2019 Feb;13(1):3-10.
- doi: 10.4162/nrp.2019.13.1.3
BACKGROUND/OBJECTIVES: The NAD+ precursor nicotinamide riboside (NR) is a type of vitamin B3 found in cow's milk and yeast-containing food products such as beer. Recent studies suggested that NR prevents... -
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- Swertiamarin ameliorates carbon tetrachloride-induced hepatic apoptosis via blocking the PI3K/Akt pathway in rats
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Zhang Q, Chen K, Wu T, Song H
- KMID: 2443612
- Korean J Physiol Pharmacol.
- 2019 Jan;23(1):21-28.
- doi: 10.4196/kjpp.2019.23.1.21
Swertiamarin (STM) is an iridoid compound that is present in the Gentianaceae swertia genus. Here we investigated antiapoptotic effects of STM on carbon tetrachloride (CClâ‚„)-induced liver injury and its possible... -
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- High-content analysis of in vitro hepatocyte injury induced by various hepatotoxicants
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Tham NT, Hwang SR, Bang JH, Yi H, Park YI, Kang SJ, Kang HG, Kim YS, Ku HO
- KMID: 2434775
- J Vet Sci.
- 2019 Jan;20(1):34-42.
- doi: 10.4142/jvs.2019.20.1.34
In vitro prediction of hepatotoxicity can enhance the performance of non-clinical animal testing for identifying chemical hazards. In this study, we assessed high-content analysis (HCA) using multi-parameter cell-based assays as... -
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- Relationship between Telomere Maintenance and Liver Disease
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Barnard A, Moch A, Saab S
- KMID: 2434385
- Gut Liver.
- 2019 Jan;13(1):11-15.
- doi: 10.5009/gnl18081
Previous studies have established a correlation between increasing chronological age and risk of cirrhosis. This pattern raised interest in the role of telomeres and the telomerase complex in the pathogenesis... -
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- The role of hepatic macrophages in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis
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Cha JY, Kim DH, Chun KH
- KMID: 2459288
- Lab Anim Res.
- 2018 Dec;34(4):133-139.
- doi: 10.5625/lar.2018.34.4.133
Nonalcoholic steatohepatitis (NASH) is becoming common chronic liver disease because of the increasing global prevalence of obesity and consequently Nonalcoholic fatty liver disease (NAFLD). However, the mechanism for progression of... -
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- Fasiglifam (TAK-875), a G Protein-Coupled Receptor 40 (GPR40) Agonist, May Induce Hepatotoxicity through Reactive Oxygen Species Generation in a GPR40-Dependent Manner
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Kim M, Gu GJ, Koh YS, Lee SH, Na YR, Seok SH, Lim KM
- KMID: 2427514
- Biomol Ther.
- 2018 Nov;26(6):599-607.
- doi: 10.4062/biomolther.2017.225
Fasiglifam (TAK-875) a G-protein coupled receptor 40 (GPR40) agonist, significantly improves hyperglycemia without hypoglycemia and weight gain, the major side effects of conventional anti-diabetics. Unfortunately, during multi-center Phase 3 clinical... -
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- Alteration of MRP2 expression and the graft outcome after liver transplantation
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Yi NJ, Kim J, Choi Y, Kim H, Lee KB, Jang JJ, Lee JY, Lee JM, Han JK, Lee KW, Suh KS
- KMID: 2422934
- Ann Surg Treat Res.
- 2018 Nov;95(5):249-257.
- doi: 10.4174/astr.2018.95.5.249
PURPOSE: Multidrug resistance-associated protein (MRP) 2 is a glutathione conjugate in the canalicular membrane of hepatocytes. Early graft damage after liver transplantation (LT) can result in alteration of MRP2 expression.... -
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- S100A4 Gene is Crucial for Methionine-Choline-Deficient Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice
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Zhang YH, Ma DQ, Ding DP, Li J, Chen LL, Ao KJ, Tian YY
- KMID: 2422491
- Yonsei Med J.
- 2018 Nov;59(9):1064-1071.
- doi: 10.3349/ymj.2018.59.9.1064
PURPOSE: To explore the influence of S100 calcium binding protein A4 (S100A4) knockout (KO) on methionine-choline-deficient (MCD) diet-induced non-alcoholic fatty liver disease (NAFLD) in mice. MATERIALS AND METHODS: S100A4 KO mice... -
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