Korean J Sports Med.  2011 Dec;29(2):112-117. 10.5763/kjsm.2011.29.2.112.

Effect of Resistance Exercise Training on Mustn1 mRNA Expression in Rat Skeletal Muscle

  • 1Research Institute for Sports Science, Hanyang University, Seoul, Korea. hyriss@hanyang.ac.kr


The aim of this investigation was to determine if resistance exercise improved musculoskeletal embryonic nuclear protein 1 (Mustn1) mRNA expression in skeletal muscle of rat. Thirty-two male Sprague-Dawley rats were separated into sedentary (control group, CON; n=16) and exercise-trained groups (resistance exercise group, REG; n=16). CON and REG subsequently were separated into 4 weeks group (4 weeks CON, 4 weeks REG) and 8 weeks group (8 weeks CON, 8 weeks REG). The rats in the resistance exercise group were trained to climb a 1-m vertical (85 degree incline) ladder with weights secured to their tail, and they climbed the ladder 10 times 3 days per week for 8 weeks progressively. After weeks of exercise, skeletal muscle was taken from the flexor halucis longus. After separating the total ribonucleic acid (RNA) of each group, quantitative polymerase chain reaction was used to analyze RNA quantitatively. After 4 weeks of resistance exercise, Mustn1 mRNA expression increased significantly in REG compared to CON (p<0.001). Additionally, there was a significant increase of Mustn1 mRNA expression in 8 weeks REG compared to 8 weeks CON (p<0.01). Interestingly, there was a significant difference in Mustn1 mRNA between 4 weeks REG and 8 weeks REG (p<0.01). In the REG, Mustn1 mRNA increased by 3.7-fold and 2.1-fold relative to CON, respectively. In conclusion, the resistance training increased Mustn1 mRNA expression in skeletal muscle of rat. This shows that the Mustn1 mRNA expression gives positive effect on myogenesis and muscle regeneration in skeletal muscle of rat results from resistance ladder exercise.


Resistance training; Mustn1
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