- Identification of a Novel Splice Variant (c.423-8A>G) of APC by RNA Sequencing
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Kim A, Kim HK, Ahn S, Hong YS, Lim SB, Byeon JS, Chun S, Min WK, Lee W
- KMID: 2470335
- Ann Lab Med.
- 2020 Jul;40(4):345-347.
- doi: 10.3343/alm.2020.40.4.345
No abstract available. -
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- Understanding the Molecular Mechanisms of Asthma through Transcriptomics
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Park HW, Weiss ST
- KMID: 2471225
- Allergy Asthma Immunol Res.
- 2020 May;12(3):399-411.
- doi: 10.4168/aair.2020.12.3.399
The transcriptome represents the complete set of RNA transcripts that are produced by the genome under a specific circumstance or in a specific cell. High-throughput methods, including microarray and bulk... -
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- Effect of saccharin on inflammation in 3T3-L1 adipocytes and the related mechanism
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Kim HL, Ha AW, Kim WK
- KMID: 2471878
- Nutr Res Pract.
- 2020 Apr;14(2):109-116.
- doi: 10.4162/nrp.2020.14.2.109
BACKGROUND/OBJECTIVES: Excessive intake of simple sugars induces obesity and increases the risk of inflammation. Thus, interest in alternative sweeteners as a sugar substitute is increasing. The purpose of this study... -
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- Epigenetic Regulation of Filaggrin Gene Expression in Human Epidermal Keratinocytes
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Lee J, Jang A, Seo SJ, Myung SC
- KMID: 2471338
- Ann Dermatol.
- 2020 Apr;32(2):122-129.
- doi: 10.5021/ad.2020.32.2.122
BACKGROUND: Loss-of-function mutations in the filaggrin gene (FLG), which encodes an epidermal protein crucial for the formation of a functional skin barrier, have been identified as a major predisposing factor... -
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- Effects of Hydrogen Sulfide and Nitric Oxide on the Permeability of Cultured Trabecular Meshwork Cells
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Son MS, Baek MJ, Kim JW
- KMID: 2471767
- J Korean Ophthalmol Soc.
- 2020 Mar;61(3):267-273.
- doi: 10.3341/jkos.2020.61.3.267
PURPOSE: To investigate the effects of hydrogen sulfide (Hâ‚‚S) on the permeability of a cultured human trabecular meshwork cells (HTMC) monolayer and its interaction with nitric oxide (NO). METHODS: After exposing... -
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- Eupatilin downregulates phorbol 12-myristate 13-acetate-induced MUC5AC expression via inhibition of p38/ERK/JNK MAPKs signal pathway in human airway epithelial cells
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Cheon YH, Kim MS, Kim JY, Kim DH, Han SY, Lee JH
- KMID: 2471037
- Korean J Physiol Pharmacol.
- 2020 Mar;24(2):157-163.
- doi: 10.4196/kjpp.2020.24.2.157
Chronic inflammatory airway diseases, such as chronic rhinosinusitis, chronic obstructive pulmonary disease, and asthma, are associated with excessive mucus production. Hence, the regulation of mucus production is important for the... -
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- Inhibition of melanogenesis by sodium 2-mercaptoethanesulfonate
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Kim JH, Oh CT, Kwon TR, Kim JH, Bak DH, Kim H, Park WS, Kim BJ
- KMID: 2471036
- Korean J Physiol Pharmacol.
- 2020 Mar;24(2):149-156.
- doi: 10.4196/kjpp.2020.24.2.149
Sodium 2-mercaptoethanesulfonate (mesna) is a protective agent that is widely used in medicine because of its antioxidant effects. Recently, reactive oxygen species (ROS) were shown to increase pigmentation. Thus, ROS... -
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- The MicroRNA hsa-let-7g Promotes Proliferation and Inhibits Apoptosis in Lung Cancer by Targeting HOXB1
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Cui F, Zhou Q, Xiao K, Ma S
- KMID: 2470917
- Yonsei Med J.
- 2020 Mar;61(3):210-217.
- doi: 10.3349/ymj.2020.61.3.210
PURPOSE: The goal of this study was to explore the effects of hsa-let-7g on cell proliferation and apoptosis, and elucidate its role in lung cancer development. MATERIALS AND METHODS: The expression... -
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- LAMC1 is a prognostic factor and a potential therapeutic target in endometrial cancer
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Kunitomi H, Kobayashi , Wu RC, Takeda T, Tominaga E, Banno K, Aoki D
- KMID: 2470864
- J Gynecol Oncol.
- 2020 Mar;31(2):e11.
- doi: 10.3802/jgo.2020.31.e11
OBJECTIVE: With the emerging significance of genetic profiles in the management of endometrial cancer, the identification of tumor-driving genes with prognostic value is a pressing need. The LAMC1 gene, encoding... -
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- Epithelial PI3K-δ Promotes House Dust Mite-Induced Allergic Asthma in NLRP3 Inflammasome-Dependent and -Independent Manners
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Kim SR, Park HJ, Lee KB, Kim HJ, Jeong JS, Cho SH, Lee YC
- KMID: 2468466
- Allergy Asthma Immunol Res.
- 2020 Mar;12(2):338-358.
- doi: 10.4168/aair.2020.12.2.338
PURPOSE: Phosphoinositide 3-kinase (PI3K)-δ-dependent Akt activation is known to play critical roles in various immune responses of white blood cells in which PI3K-δ isoform is mostly expressed in contrast to... -
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- Evidence for the Presence of Long-Lived Plasma Cells in Nasal Polyps
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Zhang YN, Song J, Zhai GT, Wang H, Luo RZ, Li JX, Liao B, Ma J, Wang H, Lu X, Liu DB, Liu Z
- KMID: 2468462
- Allergy Asthma Immunol Res.
- 2020 Mar;12(2):274-291.
- doi: 10.4168/aair.2020.12.2.274
PURPOSE: Plasma cells and immunoglobulins (Igs) play a pivotal role in the induction and maintenance of chronic inflammation in nasal polyps. During secondary immune responses, plasma cell survival and Ig... -
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- Upregulated Long Noncoding RNA LINC01234 Predicts Unfavorable Prognosis for Colorectal Cancer and Negatively Correlates With KLF6 Expression
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Jiang X, Zhu Q, Wu P, Zhou F, Chen J
- KMID: 2460913
- Ann Lab Med.
- 2020 Mar;40(2):155-163.
- doi: 10.3343/alm.2020.40.2.155
BACKGROUND: LINC01234, a long noncoding RNA (lncRNA), is overexpressed in several cancers, including colorectal cancer (CRC). We investigated the role of LINC01234 in CRC development and confirmed its correlation with... -
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- Review of a novel disease entity, immunoglobulin G4-related disease
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Maehara T, Moriyama M, Nakamura S
- KMID: 2471106
- J Korean Assoc Oral Maxillofac Surg.
- 2020 Feb;46(1):3-11.
- doi: 10.5125/jkaoms.2020.46.1.3
Immunoglobulin G4 (IgG4)-related dacryoadenitis and sialoadenitis (IgG4-DS) are part of a multiorgan fibroinflammatory condition of unknown etiology termed IgG4-related disease (IgG4-RD), which has been recognized as a single diagnostic entity... -
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- Effect of Diquafosol on Hyperosmotic Stress-induced Tumor Necrosis Factor-α and Interleukin-6 Expression in Human Corneal Epithelial Cells
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Kim YH, Yang IJ, Nguyen LT, Gum SI, Yu S, Lee GJ, Kim BA, Jung JC, Park YJ
- KMID: 2469281
- Korean J Ophthalmol.
- 2020 Feb;34(1):1-10.
- doi: 10.3341/kjo.2019.0046
PURPOSE: Diquafosol is a pharmaceutical drug used for dry eye treatment with a novel mechanism of action. It is a purinergic P2Y2 receptor agonist that promotes the secretion of tears... -
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- Advances in urinary biomarker discovery in urological research
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Kim J, Kim WT, Kim WJ
- KMID: 2469122
- Investig Clin Urol.
- 2020 Feb;61(Suppl 1):S8-S22.
- doi: 10.4111/icu.2020.61.S1.S8
A disease-specific biomarker (or biomarkers) is a characteristic reflecting a pathological condition in human body, which can be used as a diagnostic or prognostic tool for the clinical management. A... -
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- Curcumin Attenuates Acrolein-induced COX-2 Expression and Prostaglandin Production in Human Umbilical Vein Endothelial Cells
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Lee SE, Park HR, Jeon S, Han D, Park YS
- KMID: 2470810
- J Lipid Atheroscler.
- 2020 Jan;9(1):184-194.
- doi: 10.12997/jla.2020.9.1.184
OBJECTIVE: Inflammation is crucial to limiting vascular disease. Previously we reported that acrolein, a known toxin in tobacco smoke, might play an important role in the progression of atherosclerosis via... -
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- Select Macrophage Noncoding RNAs of Interest in Cardiovascular Disease
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Enchill Z, Lantz C, Thorp EB
- KMID: 2470807
- J Lipid Atheroscler.
- 2020 Jan;9(1):153-161.
- doi: 10.12997/jla.2020.9.1.153
Cardiovascular disease remains a leading cause of morbidity and mortality worldwide. Aspects of disease severity that are associated with heightened inflammation, such as during atherosclerosis or after myocardial infarction, are... -
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- Quantifications of Lipid Kinetics In Vivo Using Stable Isotope Tracer Methodology
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Kim IY, Park S, Jang J, Wolfe RR
- KMID: 2470804
- J Lipid Atheroscler.
- 2020 Jan;9(1):110-123.
- doi: 10.12997/jla.2020.9.1.110
Like other bodily materials, lipids such as plasma triacylglycerol, cholesterols, and free fatty acids are in a dynamic state of constant turnover (i.e., synthesis, breakdown, oxidation, and/or conversion to other... -
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- mTOR-coordinated Post-Transcriptional Gene Regulations: from Fundamental to Pathogenic Insights
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Yeh HS, Yong J
- KMID: 2470798
- J Lipid Atheroscler.
- 2020 Jan;9(1):8-22.
- doi: 10.12997/jla.2020.9.1.8
Post-transcriptional regulations of mRNA transcripts such as alternative splicing and alternative polyadenylation can affect the expression of genes without changing the transcript levels. Recent studies have demonstrated that these post-transcriptional... -
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- Rapid detection of deformed wing virus in honeybee using ultra-rapid qPCR and a DNA-chip
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Kim JM, Lim SJ, Kim S, Kim M, Kim B, Tai TA, Kim S, Yoon B
- KMID: 2469019
- J Vet Sci.
- 2020 Jan;21(1):e4.
- doi: 10.4142/jvs.2020.21.e4
Fast and accurate detection of viral RNA pathogens is important in apiculture. A polymerase chain reaction (PCR)-based detection method has been developed, which is simple, specific, and sensitive. In this... -
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