J Bone Metab.  2012 Nov;19(2):95-102. 10.11005/jbm.2012.19.2.95.

Relationship between Weight, Body Mass Index and Bone Mineral Density of Lumbar Spine in Women

• Kim SJ
• Yang WG
• Cho E
• Park EC

• KMID: 1975982
• DOI: http://doi.org/10.11005/jbm.2012.19.2.95

Abstract

OBJECTIVES
This study aims to identify a relationship between bone mineral density (BMD) of lumbar spine, and the weight and body mass index (BMI) in women.
METHODS
The subjects were 1,143 females who visited the public health center. BMD (T-score), height and weight were measured and age, menopause, diabetes and hypertension, exercising status and smoking status were inquired by interview.
RESULTS
Among the subjects, 362 (31.7%) were in the normal group and 781 (68.3%) were in the abnormal group. As the result of the logistic regression analysis with BMI (Model I), the odds ratio of getting into the abnormal BMD group as age increases by 1 year marked 1.044 (95% CI = 1.009-1.080). The odds ratio of getting into the abnormal BMD group due to menopause was 2.663 (1.516-4.679) and the odds ratio according to lack of walking exercise was 2.597 (1.878-3.591). The odds ratio with 1 kg/m2 of BMI increase was 0.909 (0.862-0.959). In the logistic regression analysis with weight (Model II), the odds ratio of getting into the abnormal BMD group as age increases by 1 year marked 1.044 (1.009-1.080). The odds ratio of getting into the abnormal bone density group due to menopause was 2.575 (1.472-4.507) and the odds ratio according to lack of walking exercise was 2.598 (1.881-3.587). The odds ratio with 1 kg of weight increase was 0.963 (0.942-0.984). The Akaike's information criterion (AIC) values of Model I and Model II were 1196.18 and 1197.14 respectively, indicating Model I has the better compatibility of regression analysis model.
CONCLUSION
Weight, BMI and BMD had a positive correlation. However, the coefficient of correlation between weight and BMD was higher than the coefficient between BMI and BMD, which means low weight is much more likely to be related to osteoporosis with no other factor considered. On the other hand, under the condition considering age, height, menopause and walking exercise smoking status, low BMI is much more compatible as a risk factor for osteoporosis.

Keyword

Body mass index; Bone mineral density; Osteoporosis; Weight

MeSH Terms

Body Mass Index
Body Weight
Bone Density
Female
Hand
Humans
Hypertension
Logistic Models
Menopause
Odds Ratio
Osteoporosis
Public Health
Risk Factors
Smoke
Smoking
Spine
Walking
Smoke

Reference

1. Peck WA, Burckhardt P, Christiansen C, et al. Consensus development conference: diagnosis, prophylaxis, and treatment of osteoporosis. Am J Med. 1993. 94:646–650.

2. Riggs BL, Melton LJ 3rd. Involutional osteoporosis. N Engl J Med. 1986. 314:1676–1686.

3. Dempster DW. Osteoporosis and the burden of osteoporosis-related fractures. Am J Manag Care. 2011. 17 Suppl 6:S164–S169.

4. National Osteoporosis Foundation. Clinician's Guide to Prevention and Treatment of Osteoporosis. 2010. Washington, DC: National Osteoporosis Foundation.

5. Ross PD. Osteoporosis. Frequency, consequences, and risk factors. Arch Intern Med. 1996. 156:1399–1411.

6. Haczynski J, Jakimiuk A. Vertebral fractures: a hidden problem of osteoporosis. Med Sci Monit. 2001. 7:1108–1117.

7. Akdeniz N, Akpolat V, Kale A, et al. Risk factors for postmenopausal osteoporosis: anthropometric measurements, age, age at menopause and the time elapsed after menopause onset. Gynecol Endocrinol. 2009. 25:125–129.

8. Krall EA, Dawson-Hughes B. Smoking and bone loss among postmenopausal women. J Bone Miner Res. 1991. 6:331–338.

9. Nelson HD, Nevitt MC, Scott JC, et al. Study of Osteoporotic Fractures Research Group. Smoking, alcohol, and neuromuscular and physical function of older women. JAMA. 1994. 272:1825–1831.

10. Felson DT, Kiel DP, Anderson JJ, et al. Alcohol consumption and hip fractures: the Framingham Study. Am J Epidemiol. 1988. 128:1102–1110.

11. Kanis JA, Delmas P, Burckhardt P, et al. Guidelines for diagnosis and management of osteoporosis. The European Foundation for Osteoporosis and Bone Disease. Osteoporos Int. 1997. 7:390–406.

12. Hadzibegovic I, Miskic B, Cosic V, et al. Increased bone mineral density in postmenopausal women with type 2 diabetes mellitus. Ann Saudi Med. 2008. 28:102–104.

13. Robbins J, Schott AM, Azari R, et al. Body mass index is not a good predictor of bone density: results from WHI, CHS, and EPIDOS. J Clin Densitom. 2006. 9:329–334.