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Effects of Fluvastatin on the Pharmacokinetics of Repaglinide: Possible Role of CYP3A4 and P-glycoprotein Inhibition by Fluvastatin

Lee CK, Choi JS, Bang JS

  • Korean J Physiol Pharmacol.
  • 2013 Jun;17(3):245-251.
  • doi: 10.4196/kjpp.2013.17.3.245
The purpose of this study was to investigate the effects of fluvastatin on the pharmacokinetics of repaglinide in rats. The effect of fluvastatin on P-glycoprotein and CYP3A4 activity was evaluated....
Cytotoxic Activity and Quantitative Structure Activity Relationships of Arylpropyl Sulfonamides

Hwang YJ, Park SM, Yim CB, Im C

  • Korean J Physiol Pharmacol.
  • 2013 Jun;17(3):237-243.
  • doi: 10.4196/kjpp.2013.17.3.237
B13 is a ceramide analogue and apoptosis inducer with potent cytotoxic activity. A series of arylpropyl sulfonamide analogues of B13 were evaluated for their cytotoxicity using MTT assays in prostate...
Electrophysiological and Histologic Evaluation of the Time Course of Retinal Degeneration in the rd10 Mouse Model of Retinitis Pigmentosa

Jae SA, Ahn KN, Kim JY, Seo JH, Kim HK, Goo YS

  • Korean J Physiol Pharmacol.
  • 2013 Jun;17(3):229-235.
  • doi: 10.4196/kjpp.2013.17.3.229
Among several animal models of retinitis pigmentosa (RP), the more recently developed rd10 mouse with later onset and slower rate of retinal degeneration than rd1 mouse is a more suitable...
Activation of Lysophosphatidic Acid Receptor Is Coupled to Enhancement of Ca(2+)-Activated Potassium Channel Currents

Choi SH, Lee BH, Kim HJ, Hwang SH, Lee SM, Nah SY

  • Korean J Physiol Pharmacol.
  • 2013 Jun;17(3):223-228.
  • doi: 10.4196/kjpp.2013.17.3.223
The calcium-activated K+ (BKCa) channel is one of the potassium-selective ion channels that are present in the nervous and vascular systems. Ca2+ is the main regulator of BKCa channel activation....
2-(4-Hydroxyphenyl)-5-(3-Hydroxypropenyl)-7-Methoxybenzofuran, a Novel Ailanthoidol Derivative, Exerts Anti-Inflammatory Effect through Downregulation of Mitogen-Activated Protein Kinase in Lipopolysaccharide-Treated RAW 264.7 Cells

Kim HJ, Jun JG, Kim JK

  • Korean J Physiol Pharmacol.
  • 2013 Jun;17(3):217-222.
  • doi: 10.4196/kjpp.2013.17.3.217
We reported that ailanthoidol, a neolignan from Zanthoxylum ailanthoides and Salvia miltiorrhiza Bunge, inhibited inflammatory reactions by macrophages and protected mice from endotoxin shock. We examined the anti-inflammatory activity of...
Protective Effect of Phosphatidylcholine on Lipopolysaccharide-Induced Acute Inflammation in Multiple Organ Injury

Jung YY, Nam Y, Park YS, Lee HS, Hong SA, Kim BK, Park ES, Chung YH, Jeong JH

  • Korean J Physiol Pharmacol.
  • 2013 Jun;17(3):209-216.
  • doi: 10.4196/kjpp.2013.17.3.209
Soybean polyunsaturated phosphatidylcholine (PC) is thought to exert anti-inflammatory activities and has potent effects in attenuating acute renal failure and liver dysfunction. The aim of this study was to investigate...
5,8-Dimethoxy-2-Nonylamino-Naphthalene-1,4-Dione Inhibits Vascular Smooth Muscle Cell Proliferation by Blocking Autophosphorylation of PDGF-Receptor beta

Kim Y, Lee JJ, Lee SG, Jung SH, Han JH, Yang SY, Yun E, Song GY, Myung CS

  • Korean J Physiol Pharmacol.
  • 2013 Jun;17(3):203-208.
  • doi: 10.4196/kjpp.2013.17.3.203
As the abnormal proliferation of vascular smooth muscle cells (VSMCs) plays a critical role in the development of atherosclerosis and vascular restenosis, a candidate drug with antiproliferative properties is needed....
Anti-Oxidative Activity of Pectin and Its Stabilizing Effect on Retinyl Palmitate

Ro J, Kim Y, Kim H, Jang SB, Lee HJ, Chakma S, Jeong JH, Lee J

  • Korean J Physiol Pharmacol.
  • 2013 Jun;17(3):197-201.
  • doi: 10.4196/kjpp.2013.17.3.197
The purpose of this study was to examine the anti-oxidative activity of pectin and other polysaccharides in order to develop a cosmeceutical base having anti-oxidative effects towards retinyl palmitate (RP)....
Altered APP Carboxyl-Terminal Processing Under Ferrous Iron Treatment in PC12 Cells

Kim CH, Yoo YM

  • Korean J Physiol Pharmacol.
  • 2013 Jun;17(3):189-195.
  • doi: 10.4196/kjpp.2013.17.3.189
Amyloid-beta peptide (Abeta), generated by proteolytic cleavage of the amyloid precursor protein (APP), plays a pivotal role in the pathogenesis of Alzheimer's disease (AD). The key step in the generation...
Contradictory Effects of Superoxide and Hydrogen Peroxide on KCa3.1 in Human Endothelial Cells

Choi S, Na HY, Kim JA, Cho SE, Suh SH

  • Korean J Physiol Pharmacol.
  • 2013 Jun;17(3):181-187.
  • doi: 10.4196/kjpp.2013.17.3.181
Reactive oxygen species (ROS) are generated in various cells, including vascular smooth muscle and endothelial cells, and regulate ion channel functions. KCa3.1 plays an important role in endothelial functions. However,...

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