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14 results

Induction of Heat Shock Proteins and Antioxidant Enzymes in 2,3,7,8-TCDD-Induced Hepatotoxicity in Rats

Kim HS, Park SY, Yoo KY, Lee SK, Jung WW

  • Korean J Physiol Pharmacol.
  • 2012 Dec;16(6):469-476.
  • doi: 10.4196/kjpp.2012.16.6.469
2,3,7,8-Tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD) is an environmental toxicant with a polyhalogenated aromatic hydrocarbon structure and is one of the most toxic man-made chemicals. Exposure to 2,3,7,8-TCDD induces reproductive toxicity, immunotoxicity, and hepatotoxicity....
Effect of PRX-1 Downregulation in the Type 1 Diabetes Microenvironment

Yoo JS, Lee YJ, Hyung KE, Yoon JW, Lee IH, Park SY, Hwang KW

  • Korean J Physiol Pharmacol.
  • 2012 Dec;16(6):463-468.
  • doi: 10.4196/kjpp.2012.16.6.463
Type 1 diabetes (T1D) is caused by dysregulation of the immune system in the pancreatic islets, which eventually leads to insulin-producing pancreatic beta-cell death and destabilization of glucose homeostasis. One...
Protective Effect of ECQ on Rat Reflux Esophagitis Model

Jang HS, Han JH, Jeong JY, Sohn UD

  • Korean J Physiol Pharmacol.
  • 2012 Dec;16(6):455-462.
  • doi: 10.4196/kjpp.2012.16.6.455
This study was designed to determine the protective effect of Rumex Aquaticus Herba extracts containing quercetin-3-beta-D-glucuronopyranoside (ECQ) on experimental reflux esophagitis. Reflux esophagitis was induced by surgical procedure. The rats...
Multiple Signaling Molecules are Involved in Expression of CCL2 and IL-1beta in Response to FSL-1, a Toll-Like Receptor 6 Agonist, in Macrophages

Won K, Kim SM, Lee SA, Rhim BY, Eo SK, Kim K

  • Korean J Physiol Pharmacol.
  • 2012 Dec;16(6):447-453.
  • doi: 10.4196/kjpp.2012.16.6.447
TLR6 forms a heterodimer with TLR2 and TLR4. While proinflammatory roles of TLR2 and TLR4 are well documented, the role of TLR6 in inflammation is poorly understood. In order to...
Mechanisms of Motility Change on Trinitrobenzenesulfonic Acid-Induced Colonic Inflammation in Mice

Cheon GJ, Cui Y, Yeon DS, Kwon SC, Park BG

  • Korean J Physiol Pharmacol.
  • 2012 Dec;16(6):437-446.
  • doi: 10.4196/kjpp.2012.16.6.437
Ulcerative colitis is an inflammatory bowel disease (IBD) characterized by recurrent episodes of colonic inflammation and tissue degeneration in human or animal models. The contractile force generated by the smooth...
Synergistic Induction of iNOS by IFN-gamma and Glycoprotein Isolated from Dioscorea batatas

Huong PT, Lee MY, Lee KY, Chang IY, Lee SK, Yoon SP, Lee DC, Jeon YJ

  • Korean J Physiol Pharmacol.
  • 2012 Dec;16(6):431-436.
  • doi: 10.4196/kjpp.2012.16.6.431
Dioscorea species continue to be used in traditional Chinese medicine, and represent a major source of steroid precursors for conventional medicine. In the previous study, We isolated glycoprotein (GDB) from...
Oxygen/Glucose Deprivation and Reperfusion Cause Modifications of Postsynaptic Morphology and Activity in the CA3 Area of Organotypic Hippocampal Slice Cultures

Jung YJ, Suh EC, Lee KE

  • Korean J Physiol Pharmacol.
  • 2012 Dec;16(6):423-429.
  • doi: 10.4196/kjpp.2012.16.6.423
Brain ischemia leads to overstimulation of N-methyl-D-aspartate (NMDA) receptors, referred as excitotoxicity, which mediates neuronal cell death. However, less attention has been paid to changes in synaptic activity and morphology...
The Effect of Lidocaine.HCl on the Fluidity of Native and Model Membrane Lipid Bilayers

Park JS, Jung TS, Noh YH, Kim WS, Park WI, Kim YS, Chung IK, Sohn UD, Bae SK, Bae MK, Jang HO, Yun I

  • Korean J Physiol Pharmacol.
  • 2012 Dec;16(6):413-422.
  • doi: 10.4196/kjpp.2012.16.6.413
The purpose of this study is to investigated the mechanism of pharmacological action of local anesthetic and provide the basic information about the development of new effective local anesthetics. Fluorescent...
Effects of Human Mesenchymal Stem Cell Transplantation Combined with Polymer on Functional Recovery Following Spinal Cord Hemisection in Rats

Choi JS, Leem JW, Lee KH, Kim SS, Suh-Kim H, Jung SJ, Kim UJ, Lee BH

  • Korean J Physiol Pharmacol.
  • 2012 Dec;16(6):405-411.
  • doi: 10.4196/kjpp.2012.16.6.405
The spontaneous axon regeneration of damaged neurons is limited after spinal cord injury (SCI). Recently, mesenchymal stem cell (MSC) transplantation was proposed as a potential approach for enhancing nerve regeneration...
Inhibitory Effects of ECQ on Indomethacin-Induced Gastric Damage in Rats

Jung J, Nam Y, Sohn UD

  • Korean J Physiol Pharmacol.
  • 2012 Dec;16(6):399-404.
  • doi: 10.4196/kjpp.2012.16.6.399
We investigated inhibitory effects of extract containing quercetin-3-O-beta-D-glucuronopyranoside (ECQ) extracted from Rumex Aquaticus Herba on indomethacin-induced gastric damage in Rats. Gastritis was induced in male Sprague-Dawley rats (200~220 g) by...
Dexamethasone Induces FcgammaRIIb Expression in RBL-2H3 Cells

Silwal P, Lee MN, Lee CJ, Hong JH, Namgung U, Lee ZW, Kim J, Lim K, Kweon GR, Park JI, Park SK

  • Korean J Physiol Pharmacol.
  • 2012 Dec;16(6):393-398.
  • doi: 10.4196/kjpp.2012.16.6.393
Mast cells are involved in allergic responses, protection against pathogens and autoimmune diseases. Dexamethasone (Dex) and other glucocorticoids suppress FcepsilonRI-mediated release of inflammatory mediators from mast cells. The inhibition mechanisms...
Antinociceptive Effect of Cyperi rhizoma and Corydalis tuber Extracts on Neuropathic Pain in Rats

Choi JG, Kang SY, Kim JM, Roh DH, Yoon SY, Park JB, Lee JH, Kim HW

  • Korean J Physiol Pharmacol.
  • 2012 Dec;16(6):387-392.
  • doi: 10.4196/kjpp.2012.16.6.387
In this study, we examined the antinociceptive effect of Cyperi rhizoma (CR) and Corydalis tuber (CT) extracts using a chronic constriction injury-induced neuropathic pain rat model. After the ligation of...
Effect of Berberine on Depression- and Anxiety-Like Behaviors and Activation of the Noradrenergic System Induced by Development of Morphine Dependence in Rats

Lee B, Sur B, Yeom M, Shim I, Lee H, Hahm DH

  • Korean J Physiol Pharmacol.
  • 2012 Dec;16(6):379-386.
  • doi: 10.4196/kjpp.2012.16.6.379
The purpose of this study was to evaluate whether berberine (BER) administration could attenuate depression- and anxiety-like behaviors and increase corticotrophin-releasing factor (CRF) and tyrosine hydroxylase (TH) expression following chronic...
Synaptic Plasticity in Mouse Models of Autism Spectrum Disorders

Chung L, Bey AL, Jiang YH

  • Korean J Physiol Pharmacol.
  • 2012 Dec;16(6):369-378.
  • doi: 10.4196/kjpp.2012.16.6.369
Analysis of synaptic plasticity together with behavioral and molecular studies have become a popular approach to model autism spectrum disorders in order to gain insight into the pathosphysiological mechanisms and...

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