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Still a threatening opioid wave: it is time for the protagonist to step up!

Lee JH

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Current scenario and future applicability of antivirals against herpes zoster

Kim SH

Herpes zoster (HZ) is a common disease in the aging population and immunocompromised individuals, with a lifetime risk of 20%–30% that increases with age. HZ is caused by reactivation of...
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High-impact chronic pain: evaluation of risk factors and predictors

Şentürk İA, Şentürk E, Üstün I, Gökçedağ A, Yıldırım NP, İçen NK

Background: The concept of high-impact chronic pain (HICP) has been proposed for patients with chronic pain who have significant limitations in work, social life, and personal care. Recognition of HICP...
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A positive feedback loop of heparanase/ syndecan1/nerve growth factor regulates cancer pain progression

Su X, Wang B, Zhou Z, Li Z, Tong S, Chen S, Zhang N, Liu S, Zhang M

Background: The purpose of this research was to assess the role of heparanase (HPSE)/syndecan1 (SDC1)/nerve growth factor (NGF) on cancer pain from melanoma. Methods: The influence of HPSE on the biological...
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Risk analysis of musculoskeletal pain intervention using corticosteroid during COVID-19 pandemic: a cohort study

Mohamad AA, Mohamed NA

Background: Most international bodies recommended against musculoskeletal steroid injection during the COVID-19 pandemic, fearing that the immunosuppressive effects of the steroid could worsen COVID-19 infection, thus prolonging the suffering of...
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An investigation of the relationship between cutaneous allodynia and kinesiophobia, gastrointestinal system symptom severity, physical activity and disability in individuals with migraine

Altay H, Celenay ST

Background: To investigate the relationship between cutaneous allodynia (CA) and kinesiophobia, gastrointestinal system (GIS) symptom severity, physical activity, and disability, and to determine whether CA, pain, and disability were influencing...
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Imbalance in the spinal serotonergic pathway induces aggravation of mechanical allodynia and microglial activation in carrageenan inflammation

Jin J, Kang DH, Jeon J, Lee HG, Kim WM, Yoon MH, Choi JI

Background: This study investigated the effect of an excess and a deficit of spinal 5-hydroxytryptamine (5-HT) on the mechanical allodynia and neuroglia activation in a rodent pain model of carrageenan...
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No more tears from surgical site infections in interventional pain management

Lim S, Yoo YM, Kim KH

As the field of interventional pain management (IPM) grows, the risk of surgical site infections (SSIs) is increasing. SSI is defined as an infection of the incision or organ/space that...
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Comparison of ultrasound-guided subacromial corticosteroid and ozone (O2-O3 ) injections in the treatment of chronic rotator cuff tendinopathy: a randomized clinical trial

Atar M, Korkmaz N, Aslan SG, Tezen , Köylü SU, Demir Y, Kesikburun S

Background: The authors aimed to compare the effects of a one-time ultrasound (US)-guided subacromial corticosteroid injection and three-time ozone (O2-O3 ) injection in patients with chronic supraspinatus tendinopathy. Methods: Participants were...
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Primary somatosensory cortex and periaqueductal gray functional connectivity as a marker of the dysfunction of the descending pain modulatory system in fibromyalgia

Soldatelli M, Franco , Picon F, Duarte J, Scherer R, Bandeira J, Zortea M, Torres ILdS, Fregni F, Caumo W

Background: Resting-state functional connectivity (rs-FC) may aid in understanding the link between painmodulating brain regions and the descending pain modulatory system (DPMS) in fibromyalgia (FM). This study investigated whether the...
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Measurement of S1 foramen depth for ultrasound-guided S1 transforaminal epidural injection

Kim YS, Park S, Lee C, Lee SK, Doo AR, Son JS

Background: Ultrasound-guided first sacral transforaminal epidural steroid injection (S1 TFESI) is a useful and easily applicable alternative to fluoroscopy or computed tomography (CT) in lumbosacral radiculopathy. When a needle approach...
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The mechanism of human neural stem cell secretomes improves neuropathic pain and locomotor function in spinal cord injury rat models: through antioxidant, anti-inflammatory, anti-matrix degradation, and neurotrophic activities

Semita IN, Utomo DN, Suroto H, Sudiana IK, Gandi P

Background: Globally, spinal cord injury (SCI) results in a big burden, including 90% suffering permanent disability, and 60%–69% experiencing neuropathic pain. The main causes are oxidative stress, inflammation, and degeneration....
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