Allergy Asthma Immunol Res.  2020 Jul;12(4):563-578. 10.4168/aair.2020.12.4.563.

The KAAACI/KDA Evidence-Based Practice Guidelines for Chronic Spontaneous Urticaria in Korean Adults and Children: Part 1. Definition, Methodology and First-line Management

Affiliations
  • 1Department of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
  • 2Department of Dermatology, Inje University Ilsan Paik Hospital, Ilsan, Korea
  • 3Department of Dermatology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea
  • 4Department of Internal Medicine, Kangwon National University School of Medicine, Chuncheon, Korea
  • 5Department of Internal Medicine, St. Carollo General Hospital, Suncheon, Korea
  • 6Department of Dermatology, Dankook University College of Medicine, Cheonan, Korea
  • 7Department of Pulmonology, Allergy and Critical Care Medicine, CHA Bundang Medical Center, CHA University, Seongnam, Korea
  • 8Department of Internal Medicine, College of Medicine, Ewha Woman's University, Seoul, Korea
  • 9Department of Internal Medicine, Korea University Medical Center Anam Hospital, Seoul, Korea
  • 10Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Korea
  • 11Department of Dermatology, Hanyang University Guri Hospital, Guri, Korea
  • 12Department of Dermatology, Eunpyeong St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea
  • 13Division of Pulmonology and Allergy, Department of Internal Medicine, Gyeongsang National University Changwon Hospital, Changwon, Korea
  • 14Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea
  • 15Institute for Evidence-based Medicine, Department of Preventive Medicine, College of Medicine, Korea University, Seoul, Korea
  • 16Department of Dermatology, Hallym University College of Medicine, Seoul, Korea
  • 17Department of Pediatrics, Inje University Sanggye Paik Hospital, Seoul, Korea
  • 18Department of Dermatology, Gachon University School of Medicine Gil Medical Center, Incheon, Korea
  • 19Division of Allergy and Immunology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
  • 20Department of Dermatology, Chung-Ang University College of Medicine, Seoul, Korea
  • 21Department of Allergy and Clinical Immunology, Kyungpook National University Chilgok Hospital, School of Medicine, Kyungpook National University, Daegu, Korea
  • 22Department of Dermatology, SMG-SNU Boramae Medical Center, Seoul, Korea
  • 23Department of Dermatology, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon, Korea
  • 24Department of Dermatology, College of Medicine, Ewha Woman's University, Seoul, Korea
  • 25Department of Pediatrics, Korea University College of Medicine, Seoul, Korea
  • 26Department of Pediatrics, Eulji General Hospital, Eulji University School of Medicine, Seoul, Korea
  • 27Division of Pulmonology and Allergy, Department of Internal Medicine, Pusan National University Yangsan Hospital, Yangsan, Korea
  • 28Department of Dermatology, College of Medicine, the Catholic University of Korea, Seoul, Korea
  • 29Department of Dermatology, School of Medicine, Eulji University, Daejeon, Korea
  • 30Department of Dermatology, Seoul St. Mary's Hospital, Brain Korea 21 PLUS Project for Medical Science, College of Medicine, The Catholic University of Korea, Seoul, Korea
  • 31Wirye Seoul Doctors Hospital, Seongnam, Korea
  • 32Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea
  • 33Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea
  • 34Department of Pediatrics, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, Korea
  • 35Department of Dermatology, Korea University College of Medicine, Seoul, Korea
  • 36Department of Dermatology, Veterans Health Service Medical Center, Seoul, Korea
  • 37Department of Pediatrics, Kyung Hee University Hospital at Gangdong, School of Medicine Kyung Hee University, Seoul, Korea
  • 38Department of Pulmonology and Allergy, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, Korea
  • 39Allergy and Clinical Immunology Research Center, Hallym University College of Medicine, Chuncheon, Korea
  • 40Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea
  • 41Department of Dermatology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
  • 42Department of Pediatrics, School of Medicine, Inha University, Incheon, Korea
  • 43Department of Dermatology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea

Abstract

Chronic spontaneous urticaria (CSU) is defined as the occurrence of spontaneous wheals, angioedema, or both for >6 weeks in the absence of specific causes. It is a common condition associated with substantial disease burden both for affected individuals and societies in many countries, including Korea. CSU frequently persists for several years and requires high-intensity treatment; therefore, patients experience deteriorations in quality of life and medication-associated complications. During the last decade, there have been major advances in the pharmacological treatment of CSU and there is an outstanding need for evidence-based guidelines that reflect clinical practice in Korea. The guidelines reported here represent a joint initiative of the Korean Academy of Asthma, Allergy and Clinical Immunology and the Korean Dermatological Association, and aim to provide evidence-based guidance for the management of CSU in Korean adults and children. In Part 1, disease definition, guideline scope and development methodology as well as evidence-based recommendations on the use of antihistamines and corticosteroids are summarized.

Keyword

Urticaria; guideline; disease management; therapeutics
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