J Korean Med Sci.  2019 May;34(19):e145. 10.3346/jkms.2019.34.e145.

Influence of Local Myocardial Infarction on Endothelial Function, Neointimal Progression, and Inflammation in Target and Non-Target Vascular Territories in a Porcine Model of Acute Myocardial Infarction

  • 1Department of Internal Medicine and Cardiovascular Center, Chosun University Hospital, Chosun University College of Medicine, Gwangju, Korea.
  • 2Cardiovascular Research Center, Chonnam National University Hospital, Gwangju, Korea. myungho@chollian.net
  • 3Division of Cardiology, Department of Internal Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
  • 4Korea Cardiovascular Stent Research Institute, Jangseong, Korea.
  • 5Cardiovascular Convergence Research Center of Chonnam National University Hospital Designated by Korea Ministry of Health and Welfare, Gwangju, Korea.
  • 6Research Institute of Medical Sciences, Chonnam National University, Gwangju, Korea.
  • 7CGBio Co. Ltd., Jangseong, Korea.
  • 8Biomedical Research Institute, Chonnam National University Hospital, Gwangju, Korea.
  • 9College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu, Korea.
  • 10Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon, Korea.
  • 11Department of Medicine, Keimyung University Dongsan Medical Center, Daegu, Korea.
  • 12Department of Medicine, Inje University Ilsan Paik Hospital, Goyang, Korea.
  • 13Department of Internal Medicine and Cardiovascular Center, Seoul National University Hospital, Seoul, Korea.
  • 14Institute on Aging, Seoul National University, Seoul, Korea.
  • 15Futuristic Animal Resource and Research Center, Korea Research Institute of Bioscience and Biotechnology, Ochang, Korea. dvmlim96@kribb.re.kr


Patients with acute myocardial infarction (AMI) have worse clinical outcomes than those with stable coronary artery disease despite revascularization. Non-culprit lesions of AMI also involve more adverse cardiovascular events. This study aimed to investigate the influence of AMI on endothelial function, neointimal progression, and inflammation in target and non-target vessels.
In castrated male pigs, AMI was induced by balloon occlusion and reperfusion into the left anterior descending artery (LAD). Everolimus-eluting stents (EES) were implanted in the LAD and left circumflex (LCX) artery 2 days after AMI induction. In the control group, EES were implanted in the LAD and LCX in a similar fashion without AMI induction. Endothelial function was assessed using acetylcholine infusion before enrollment, after the AMI or sham operation, and at 1 month follow-up. A histological examination was conducted 1 month after stenting.
A total of 10 pigs implanted with 20 EES in the LAD and LCX were included. Significant paradoxical vasoconstriction was assessed after acetylcholine challenge in the AMI group compared with the control group. In the histologic analysis, the AMI group showed a larger neointimal area and larger area of stenosis than the control group after EES implantation. Peri-strut inflammation and fibrin formation were significant in the AMI group without differences in injury score. The non-target vessel of the AMI also showed similar findings to the target vessel compared with the control group.
In the pig model, AMI events induced endothelial dysfunction, inflammation, and neointimal progression in the target and non-target vessels.


Myocardial Infarction; Neointimal Formation; Endothelium; Inflammation; Drug-Eluting Stents

MeSH Terms

Balloon Occlusion
Constriction, Pathologic
Coronary Artery Disease
Drug-Eluting Stents
Follow-Up Studies
Myocardial Infarction*
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