- Inhibition of DNMT3B and PI3K/AKT/mTOR and ERK Pathways as a Novel Mechanism of Volasertib on Hypomethylating Agent-Resistant Cells
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Choi EJ, Koo BK, Hur EH, Moon JH, Kim JY, Park HS, Choi Y, Lee KH, Lee JH, Choi EK, Lee JH
- KMID: 2541791
- Biomol Ther.
- 2023 May;31(3):319-329.
- doi: 10.4062/biomolther.2022.117
Resistance to hypomethylating agents (HMAs) in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) is a concerning problem. Polo-like kinase 1 (PLK1) is a key cell cycle modulator and is... -
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- Impact of Evolutionary Changes in Nonalcoholic Fatty Liver Disease on Lung Function Decline
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Lee HW, Chung GE, Koo BK, Sim H, Choi M, Lee DH, Choi SH, Kwak SH, Kim DK, Kim W, obotITEoN(c
- KMID: 2538165
- Gut Liver.
- 2023 Jan;17(1):139-149.
- doi: 10.5009/gnl210545
Background/Aims: A relationship between fatty liver and lung function impairment has been identified, and both are independently associated with metabolic dysfunction. However, the temporal relationship between changes in fatty liver... -
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- The Clinical Impact of β-Blocker Therapy on Patients With Chronic Coronary Artery Disease After Percutaneous Coronary Intervention
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Park J, Han JK, Kang J, Chae IH, Lee SY, Choi YJ, Rhew JY, Rha SW, Shin ES, Woo SI, Lee HC, Chun KJ, Kim D, Jeong JO, Bae JW, Yang HM, Park KW, Kang HJ, Koo BK, Kim HS
- KMID: 2530736
- Korean Circ J.
- 2022 Jul;52(7):544-555.
- doi: 10.4070/kcj.2021.0395
Background and Objectives: The outcome benefits of β-blockers in chronic coronary artery disease (CAD) have not been fully assessed. We evaluated the prognostic impact of β-blockers on patients with chronic... -
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- Erratum: Correction of Text in the Article “Prasugrel-based De-Escalation of Dual Antiplatelet Therapy After Percutaneous Coronary Intervention in Patients With STEMI”
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Ki YJ, Lee BK, Park KW, Bae JW, Hwang D, Kang J, Han JK, Yang HM, Kang HJ, Koo BK, Kim DB, Chae IH, Moon KW, Park HW, Won KB, Jeon DW, Han KR, Choi SW, Ryu JK, Jeong MH, Cha KS, Kim HS, on behalf of the HOST-RP-ACS investigators
- KMID: 2530459
- Korean Circ J.
- 2022 Jun;52(6):483-484.
- doi: 10.4070/kcj.2022.0999
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- Prasugrel-based De-Escalation of Dual Antiplatelet Therapy After Percutaneous Coronary Intervention in Patients With STEMI
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Ki YJ, Lee BK, Park KW, Bae JW, Hwang D, Kang J, Han JK, Yang HM, Kang HJ, Koo BK, Kim DB, Chae IH, Moon KW, Park HW, Won KB, Jeon DW, Han KR, Choi SW, Ryu JK, Jeong MH, Cha KS, Kim HS, obotHRAi
- KMID: 2528025
- Korean Circ J.
- 2022 Apr;52(4):304-319.
- doi: 10.4070/kcj.2021.0293
Background and Objectives: De-escalation of dual-antiplatelet therapy through dose reduction of prasugrel improved net adverse clinical events (NACEs) after acute coronary syndrome (ACS), mainly through the reduction of bleeding without... -
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- Organoid Studies in COVID-19 Research
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Kim J, Koo BK, Clevers H
- KMID: 2526734
- Int J Stem Cells.
- 2022 Feb;15(1):3-13.
- doi: 10.15283/ijsc21251
The current COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has completely changed human life for more than two years. Upon the emergence of this new lethal... -
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- Differential Prognostic Implications of Pre- and Post-Stent Fractional Flow Reserve in Patients Undergoing Percutaneous Coronary Intervention
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Zhang J, Hwang D, Yang S, Kim CH, Lee JM, Nam CW, Shin ES, Doh JH, Hoshino M, Hamaya R, Kanaji Y, Murai T, Zhang JJ, Ye F, Li X, Ge Z, Chen SL, Kakuta T, Koo BK
- KMID: 2524169
- Korean Circ J.
- 2022 Jan;52(1):47-59.
- doi: 10.4070/kcj.2021.0128
Background and Objectives: The influence of pre-intervention coronary physiologic status on outcomes post percutaneous coronary intervention (PCI) is not well known. We sought to investigate the prognostic implications of pre-PCI... -
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- Impact of COVID-19 and Associated Preventive Measures on Cardiometabolic Risk Factors in South Korea
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Sohn M, Koo BK, Yoon HI, Song KH, Kim ES, Kim HB, Lim S
- KMID: 2521073
- J Obes Metab Syndr.
- 2021 Sep;30(3):248-260.
- doi: 10.7570/jomes21046
Background: During the coronavirus disease 2019 (COVID-19) pandemic, preventive measures mandated by government policies have included the closure of exercise facilities and movement restriction, which can lead to an unhealthy... -
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- Non-invasive vs. Invasive Functional Tests after Coronary Stent Implantation
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Hwang D, Koo BK
- KMID: 2516218
- Korean Circ J.
- 2021 Jun;51(6):549-550.
- doi: 10.4070/kcj.2021.1561
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- Coronary Artery Lumen Segmentation Using Location– Adaptive Threshold in Coronary Computed Tomographic Angiography: A Proof-of-Concept
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Shin CI, Park SJ, Kim JH, Yoon YE, Park EA, Koo BK, Lee W
- KMID: 2515057
- Korean J Radiol.
- 2021 May;22(5):688-696.
- doi: 10.3348/kjr.2020.0296
Objective: To compare the lumen parameters measured by the location-adaptive threshold method (LATM), in which the inter- and intra-scan attenuation variabilities of coronary computed tomographic angiography (CCTA) were corrected, and... -
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- Letter: Effects of 6 Months of Dapagliflozin Treatment on Metabolic Profile and Endothelial Cell Dysfunction for Obese Type 2 Diabetes Mellitus Patients without Atherosclerotic Cardiovascular Disease (J Obes Metab Syndr 2020;29:215-21)
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Koo BK
- KMID: 2514144
- J Obes Metab Syndr.
- 2021 Mar;30(1):72-73.
- doi: 10.7570/jomes20133
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- Physiologic Assessment after Coronary Stent Implantation
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Hwang D, Yang S, Zhang J, Koo BK
- KMID: 2513517
- Korean Circ J.
- 2021 Mar;51(3):189-201.
- doi: 10.4070/kcj.2020.0548
The presence of myocardial ischemia is a prerequisite for the benefit of coronary revascularization. In the cardiac catheterization laboratory, fractional flow reserve and non-hyperemic pressure ratios are used to define... -
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- Long-term efficacy of vasodilating β-blocker in patients with acute myocardial infarction: nationwide multicenter prospective registry
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Chung J, Han JK, Yang HM, Park KW, Kang HJ, Koo BK, Jeong MH, Kim HS, on behalf of investigators for Korea Acute Myocardial Infarction Registry (KAMIR)
- KMID: 2513814
- Korean J Intern Med.
- 2021 Mar;36(Suppl 1):S62-S71.
- doi: 10.3904/kjim.2020.135
Background/Aims: Long-term benefit of vasodilating β-blockers is unknown. This study aimed to investigate the long-term benefit of vasodilating β-blockers over conventional β-blockers in patients with acute myocardial infarction (AMI). Methods: Using... -
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- Progression of ascending aortopathy may not occur after transcatheter aortic valve replacement in severe bicuspid aortic stenosis
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Jung JH, Kim HK, Park JB, Lee SP, Koo BK, Kim YJ, Kim HS, Sohn DW
- KMID: 2513744
- Korean J Intern Med.
- 2021 Mar;36(2):332-341.
- doi: 10.3904/kjim.2019.089
Background/Aims: We evaluated changes in the ascending aorta dimension post-transcatheter aortic valve replacement (TAVR) in bicuspid aortic valve (BiAV) and tricuspid aortic valve (TAV) patients. Methods: Patients with severe aortic stenosis... -
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- Association of Quantitative Flow Ratio with Lesion Severity and Its Ability to Discriminate Myocardial Ischemia
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Dai N, Hwang D, Lee JM, Zhang J, Tong Y, Jeon KH, Paeng JC, Cheon GJ, Koo BK, Ge J
- KMID: 2512450
- Korean Circ J.
- 2021 Feb;51(2):126-139.
- doi: 10.4070/kcj.2020.0375
Background and Objectives: Quantitative flow ratio (QFR) is an angiography-based technique for functional assessment of coronary artery stenosis. This study investigated the response of QFR to different degree of stenosis... -
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- Metformin Preserves Peripheral Nerve Damage with Comparable Effects to Alpha Lipoic Acid in Streptozotocin/High-Fat Diet Induced Diabetic Rats (Diabetes Metab J 2020;44:842-53)
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Koo BK
- KMID: 2514082
- Diabetes Metab J.
- 2021 Jan;45(1):125-126.
- doi: 10.4093/dmj.2020.0280
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- Hypertriglyceridemia Is an Independent Risk Factor for Cardiovascular Diseases in Korean Adults Aged 30–49 Years: a Nationwide Population-Based Study
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Koo BK, Park S, Han KD, Moon MK
- KMID: 2512925
- J Lipid Atheroscler.
- 2021 Jan;10(1):88-98.
- doi: 10.12997/jla.2021.10.1.88
Objective: This study was conducted to estimate the incidence of cardiovascular disease (CVD) independently from low-density lipoprotein (LDL) cholesterol according to triglyceride (TG) levels in young adults. Methods: Subjects aged 30–49... -
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- Long-term Patient Prognostication by Coronary Flow Reserve and Index of Microcirculatory Resistance: International Registry of Comprehensive Physiologic Assessment
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Lee JM, Choi KH, Doh JH, Nam CW, Shin ES, Hoshino M, Murai T, Yonetsu T, Mejía-Rentería H, Kakuta T, Escaned J, Koo BK
- KMID: 2507006
- Korean Circ J.
- 2020 Oct;50(10):890-903.
- doi: 10.4070/kcj.2020.0083
Background and Objectives: Recent guideline recommends evaluation using of coronary flow reserve (CFR) and index of microcirculatory resistance (IMR) in patients with functionally insignificant stenosis. We evaluated clinical implications of... -
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- Acute ST-elevation myocardial infarction due to prosthetic valve endocarditis after transcatheter aortic valve implantation
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Cho JH, Han JK, Yang HM, Koo BK, Kim HS
- KMID: 2504196
- Korean J Intern Med.
- 2020 Jul;35(4):1020-1021.
- doi: 10.3904/kjim.2018.356
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- Glucose Metabolism in Pregnant Women with Normal Glucose Tolerance
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Koo BK
- KMID: 2503961
- J Korean Diabetes.
- 2020 Jun;21(2):64-68.
- doi: 10.4093/jkd.2020.21.2.64
Insulin resistance increases from conception into late pregnancy in women with normal glucose tolerance as well as women with gestational diabetes. Increasing insulin resistance during pregnancy permits adequate supply of... -
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