- Interaction of genetic background and exercise training intensity on endothelial function in mouse aorta
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Kim SK, Avila JJ, Massett MP
- KMID: 2466570
- Korean J Physiol Pharmacol.
- 2020 Jan;24(1):53-68.
- doi: 10.4196/kjpp.2020.24.1.53
The purpose of this study was to characterize the genetic contribution to endothelial adaptation to exercise training. Vasoreactivity was assessed in aortas from four inbred mouse strains (129S1, B6, NON,... -
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- Telmisartan Inhibits Nitric Oxide Production and Vessel Relaxation via Protein Phosphatase 2A-mediated Endothelial NO Synthase-Ser¹¹â·â¹ Dephosphorylation
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Cho DH
- KMID: 2461172
- J Korean Med Sci.
- 2019 Nov;34(42):e266.
- doi: 10.3346/jkms.2019.34.e266
BACKGROUND: Apart from its blood pressure-lowering effect by blocking the renin-angiotensin-aldosterone system, telmisartan, an angiotensin II type 1 receptor blocker (ARB), exhibits various ancillary effects including cardiovascular protective effects in... -
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- Pyridostigmine in Pediatric Intestinal Pseudo-obstruction: Case Report of a 2-year Old Girl and Literature Review
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Di Nardo G, Viscogliosi F, Esposito F, Stanghellini V, Villa MP, Parisi P, Morlando A, Calò G, De Giorgio R
- KMID: 2460479
- J Neurogastroenterol Motil.
- 2019 Oct;25(4):508-514.
- doi: 10.5056/jnm19078
Pediatric chronic intestinal pseudo-obstruction is a rare disorder characterized by a severe impairment of gastrointestinal motility leading to intestinal obstruction symptoms in the absence of mechanical causes. The diagnosis is... -
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- Neuroimmune interactions and kidney disease
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Hasegawa S, Inoue T, Inagi R
- KMID: 2457720
- Kidney Res Clin Pract.
- 2019 Sep;38(3):282-294.
- doi: 10.23876/j.krcp.19.014
The autonomic nervous system plays critical roles in maintaining homeostasis in humans, directly regulating inflammation by altering the activity of the immune system. The cholinergic anti-inflammatory pathway is a well-studied... -
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- A Novel Immunomodulatory Mechanism Dependent on Acetylcholine Secreted by Human Bone Marrow-derived Mesenchymal Stem Cells
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Yi TG, Cho YK, Lee HJ, Kim J, Jeon MS, Ham DS, Kim WC, Song SU
- KMID: 2465901
- Int J Stem Cells.
- 2019 Jul;12(2):315-330.
- doi: 10.15283/ijsc18098
BACKGROUND AND OBJECTIVES: Mesenchymal stem cells (MSCs) are used to treat autoimmune or inflammatory diseases. Our aim was to determine the immunomodulatory mechanisms elicited by MSCs during inflammation. METHODS AND RESULTS:... -
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- Association between Ischemic Electrocardiographic Changes during Acetylcholine Provocation Test and Long-Term Clinical Outcomes in Patients with Vasospastic Angina
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Im SI, Rha SW, Choi BG, Na JO, Choi CU, Lim HE, Kim JW, Kim EJ, Park CG, Seo HS
- KMID: 2451770
- Kosin Med J.
- 2019 Jun;34(1):1-14.
- doi: 10.7180/kmj.2019.34.1.1
OBJECTIVES: Intracoronary injection of acetylcholine (Ach) has been shown to induce significant coronary artery spasm (CAS) in patients with vasospastic angina. Clinical significance and angiographic characteristics of patients with ischemic... -
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- Basal Forebrain Cholinergic-induced Activation of Cholecystokinin Inhibitory Neurons in the Basolateral Amygdala
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Lee S, Kim JH
- KMID: 2451068
- Exp Neurobiol.
- 2019 Jun;28(3):320-328.
- doi: 10.5607/en.2019.28.3.320
The basolateral amygdala (BLA) receives dense projections from cholinergic neurons of the basal forebrain. Acetylcholine can contributes to amygdala-dependent behaviors: formation and extinction of fear memory and appetitive instrumental learning.... -
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- Influence of Local Myocardial Infarction on Endothelial Function, Neointimal Progression, and Inflammation in Target and Non-Target Vascular Territories in a Porcine Model of Acute Myocardial Infarction
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Kim HK, Kim HB, Lee JM, Kim SS, Bae IH, Park DS, Park JK, Shim JW, Na JY, Lee MY, Kim JS, Sim DS, Hong YJ, Nam CW, Doh JH, Park J, Koo BK, Kim SU, Lim KS, Jeong MH
- KMID: 2445803
- J Korean Med Sci.
- 2019 May;34(19):e145.
- doi: 10.3346/jkms.2019.34.e145
BACKGROUND: Patients with acute myocardial infarction (AMI) have worse clinical outcomes than those with stable coronary artery disease despite revascularization. Non-culprit lesions of AMI also involve more adverse cardiovascular events.... -
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- The Inhibitory Mechanism on Acetylcholine-Induced Contraction of Bladder Smooth Muscle in the Streptozotocin-Induced Diabetic Rat
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Han JS, Kim SJ, Nam Y, Lee HY, Kim GM, Kim DM, Sohn UD
- KMID: 2432073
- Biomol Ther.
- 2019 Jan;27(1):101-106.
- doi: 10.4062/biomolther.2018.136
Most diabetic patients experience diabetic mellitus (DM) urinary bladder dysfunction. A number of studies evaluate bladder smooth muscle contraction in DM. In this study, we evaluated the change of bladder... -
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- Feline Interstitial Cystitis Enhances Mucosa-Dependent Contractile Responses to Serotonin
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Ikeda Y, Wolf-Johnston A, Roppolo JR, Buffington CAT, Birder L
- KMID: 2431865
- Int Neurourol J.
- 2018 Dec;22(4):246-251.
- doi: 10.5213/inj.1836276.138
PURPOSE: To determine whether responses to serotonin are altered in bladder strips from cats diagnosed with a naturally occurring form of bladder pain syndrome/interstitial cystitis termed feline interstitial cystitis (FIC). METHODS:... -
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- Effects of adenosine receptor agonist on the rocuronium-induced neuromuscular block and sugammadex-induced recovery
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Kim YB, Lee S, Choi HR, In J, Chang YJ, Kim HJ, Ro YJ, Yang HS
- KMID: 2428080
- Korean J Anesthesiol.
- 2018 Dec;71(6):476-482.
- doi: 10.4097/kja.d.17.00011
BACKGROUND: Several types of receptors are found at neuromuscular presynaptic membranes. Presynaptic inhibitory A1 and facilitatory A2A receptors mediate different modulatory functions on acetylcholine release. This study investigated whether adenosine... -
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- Impact of Insulin Resistance on Acetylcholine-Induced Coronary Artery Spasm in Non-Diabetic Patients
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Kang KW, Choi BG, Rha SW
- KMID: 2422490
- Yonsei Med J.
- 2018 Nov;59(9):1057-1063.
- doi: 10.3349/ymj.2018.59.9.1057
PURPOSE: Coronary artery spasm (CAS) and diabetes mellitus (DM) are implicated in endothelial dysfunction, and insulin resistance (IR) is a major etiological cause of type 2 DM. However, the association... -
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- Role of High-affinity Choline Transporter 1 in Colonic Hypermotility in a Rat Model of Irritable Bowel Syndrome
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Lin MJ, Yu BP
- KMID: 2422854
- J Neurogastroenterol Motil.
- 2018 Oct;24(4):643-655.
- doi: 10.5056/jnm18040
BACKGROUND/AIMS: Irritable bowel syndrome (IBS) is a common disease characterized by intestinal dysmotility, the mechanism of which remains elusive. We aim to determine whether the high-affinity choline transporter 1 (CHT1),... -
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- GABA-enriched fermented Laminaria japonica improves cognitive impairment and neuroplasticity in scopolamine- and ethanol-induced dementia model mice
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Reid SN, Ryu JK, Kim Y, Jeon BH
- KMID: 2442293
- Nutr Res Pract.
- 2018 Jun;12(3):199-207.
- doi: 10.4162/nrp.2018.12.3.199
BACKGROUND/OBJECTIVES: Fermented Laminaria japonica (FL), a type sea tangle used as a functional food ingredient, has been reported to possess cognitive improving properties that may aid in the treatment of... -
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- Updated review of resistance to neuromuscular blocking agents
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Jung KT, An TH
- KMID: 2437417
- Anesth Pain Med.
- 2018 Apr;13(2):122-127.
- doi: 10.17085/apm.2018.13.2.122
Since neuromuscular blocking agents (NMBAs) were introduced to the surgical field, they have become almost mandatory for the induction and maintenance of anesthesia. However, resistance to NMBAs can develop in... -
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- Protective effects of cultured and fermented ginseng extracts against scopolamine-induced memory loss in a mouse model
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Han SH, Kim SJ, Yun YW, Nam SY, Lee HJ, Lee BJ
- KMID: 2430884
- Lab Anim Res.
- 2018 Mar;34(1):37-43.
- doi: 10.5625/lar.2018.34.1.37
This study was performed to investigate the effect of a concentrate of fermented wild ginseng root culture (HLJG0701) on memory improvement in the scopolamine (SPL)-induced memory-deficient mouse model. Eight-week-old male... -
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- Bulbar Myasthenia Gravis Superimposed in a Medullary Infarction Diagnosed by a Fiberoptic Endoscopic Evaluation of Swallowing With Simultaneous Tensilon Application
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Kim SJ, Park GY, Choi YM, Sohn DG, Kang SR, Im S
- KMID: 2400294
- Ann Rehabil Med.
- 2017 Dec;41(6):1082-1087.
- doi: 10.5535/arm.2017.41.6.1082
In the elderly, myasthenia gravis (MG) can present with bulbar symptoms, which can be clinically difficult to diagnose from other neurological comorbid conditions. We describe a case of a 75-year-old... -
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- Methidathion Poisoning
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Kim KH, Kim SH, Her C
- KMID: 2405124
- Korean J Crit Care Med.
- 2017 Nov;32(4):363-369.
- doi: 10.4266/kjccm.2016.00073
Although methidathion is an organophosphate insecticide, it is different from the other organophosphates in terms of toxicity. Because of its relatively high fat solubility, the apparent volume of methidathion distribution... -
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- Factors that affect the onset of action of non-depolarizing neuromuscular blocking agents
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Kim YB, Sung TY, Yang HS
- KMID: 2395603
- Korean J Anesthesiol.
- 2017 Oct;70(5):500-510.
- doi: 10.4097/kjae.2017.70.5.500
Neuromuscular blockade plays an important role in the safe management of patient airways, surgical field improvement, and respiratory care. Rapid-sequence induction of anesthesia is indispensable to emergency surgery and obstetric... -
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- Antihypertensive effect of ethanol extracts of Aralia elata in spontaneously hypertensive rats
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Jin JY, Park EH, Jeon YA, Lee YJ
- KMID: 2394909
- Korean J Vet Res.
- 2017 Sep;57(3):181-187.
- doi: 10.14405/kjvr.2017.57.3.181
Antihypertensive effects of ethanol extracts of Aralia elata (Miq.) Seem. (AE) were investigated in spontaneously hypertensive rats (SHR). SHR aged 14 weeks were treated for 8 weeks with AE (10... -
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