- Preclinical Evaluation of an Everolimus-Eluting Bioresorbable Vascular Scaffold Via a Long-Term Rabbit Iliac Artery Model
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Park DS, Jeong MH, Jin YJ, Na MH, Sim DS, Kim M, Cho KH, Hyun DY, Oh S, Kim JH, Lim KS, Park JK, Kim HK, Hong YJ, Kim JH, Ahn Y, Kim JH
- KMID: 2541490
- Tissue Eng Regen Med.
- 2023 Apr;20(2):239-249.
- doi: 10.1007/s13770-023-00518-z
BACKGROUND: Biodegradable poly (l-lactic acid) (PLLA), a bio safe polymer with a large elastic modulus, is widely used in biodegradable medical devices. However, because of its poor mechanical properties, a... -
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- XperCT-guided Intra-cisterna Magna Injection of Streptozotocin for Establishing an Alzheimer’s Disease Model Using the Cynomolgus Monkey (Macaca fascicularis)
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Park J, Won J, Jeon CY, Lim KS, Choi WS, Park Sh, Seo J, Cho J, Seong JB, Yeo HG, Kim K, Kim YG, Kim M, Yi KS, Lee Y
- KMID: 2537960
- Exp Neurobiol.
- 2022 Dec;31(6):409-418.
- doi: 10.5607/en22027
Till date, researchers have been developing animal models of Alzheimer’s disease (AD) in various species to understand the pathological characterization and molecular mechanistic pathways associated with this condition in humans... -
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- Sudden cardiac death as a naturally-occurring ventricular hypertrophy in Macaca fascicularis
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Yeo HG, Park J, Kim HK, Lee JM, Koo BS, An JH, Jeon CY, An YJ, Choi WS, Park SH, Seo J, Won J, Kim K, Cho J, Kim YG, Kim M, Seong JB, Huh JW, Kim SS, Lee Y, Lim KS
- KMID: 2528069
- J Biomed Transl Res.
- 2021 Sep;22(3):135-139.
- doi: 10.12729/jbtr.2021.22.3.135
Naturally occurring left ventricular hyperplasia is a rare but lethal disease. There are very few reports of this cardiac disease in captive nonhuman primates. In a colony of Macaca mulatta... -
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- Impact of Bisoprolol on Ventricular Arrhythmias in Experimental Myocardial Infarction
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Kim HK, Lim KS, Kim SS, Na JY
- KMID: 2516057
- Chonnam Med J.
- 2021 May;57(2):132-138.
- doi: 10.4068/cmj.2021.57.2.132
Following acute myocardial infarction (AMI), early use of beta-blockers (BBs) reduced the incidences of ventricular arrhythmia (VA) and death in the pre reperfusion era. However, some studies have reported a worsening... -
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- Impaired Hand Dexterity Function in a Non-human Primate Model with Chronic Parkinson’s Disease
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Seo Jc, Won Jy, Kim Kw, Park Jh, Yeo HG, Kim YG, Baek SH, Lee H, Jeon CY, Choi WS, Lee S, Kim KJ, Park SH, Son Yh, Jeong KJ, Lim KS, Kang P, Lee HY, Son HC, Huh JW, Kim YH, Lee DS, Lee SR, Choi JW, Lee Yj
- KMID: 2508474
- Exp Neurobiol.
- 2020 Oct;29(5):376-388.
- doi: 10.5607/en20040
ymptoms of Parkinson’s disease (PD) caused by loss of dopaminergic neurons are accompanied by movement disorders, including tremors, rigidity, bradykinesia, and akinesia. Non-human primate (NHP) models with PD play an... -
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- Assessment of Hand Motor Function in a Non-human Primate Model of Ischemic Stroke
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Won J, Yi KS, Choi CH, Jeon CY, Seo J, Kim K, Yeo HG, Park J, Kim YG, Jin YB, Koo BS, Lim KS, Lee S, Kim KJ, Choi WS, Park SH, Kim YH, Huh JW, Lee SR, Cha SH, Lee Y
- KMID: 2506534
- Exp Neurobiol.
- 2020 Aug;29(4):300-313.
- doi: 10.5607/en20023
Ischemic stroke results from arterial occlusion and can cause irreversible brain injury. A non-human primate (NHP) model of ischemic stroke was previously developed to investigate its pathophysiology and for efficacy... -
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- Cancer patients with neutropenic septic shock: etiology and antimicrobial resistance
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Jung SM, Kim YJ, Ryoo SM, Sohn CH, Seo DW, Lim KS, Kim WY
- KMID: 2504189
- Korean J Intern Med.
- 2020 Jul;35(4):979-987.
- doi: 10.3904/kjim.2018.306
Background/Aims: Among patients with febrile neutropenia that developed after chemotherapy, high-risk patients, such as those having clinical instability or Multinational Association of Supportive Care in Cancer score of < 21,... -
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- Effect of Renal Denervation on Suppression of PVC and QT Prolongation in a Porcine Model of Acute Myocardial Infarction
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Kim SS, Kim HK, Park HW, Jeong MH, Lim KS, Kee HJ, Ryu YH, Kim HB, Na JY, Ki YJ, Park KH, Choi DH, Lee KH, Yoon NS, Cho JG
- KMID: 2465662
- Korean Circ J.
- 2020 Jan;50(1):38-49.
- doi: 10.4070/kcj.2019.0106
BACKGROUND AND OBJECTIVES: Antiarrhythmic effect of renal denervation (RDN) after acute myocardial infarction (AMI) remains unclear. The goal of this study was to evaluate the effect of RDN on ventricular... -
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- Effect of dyslipidemia on vascular smooth muscle cell proliferation in a porcine coronary restenosis model
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Jeong KJ, Kang P, Lee HY, Son HC, Park SH, Choi WS, Koo BS, Jeon CY, Baek SH, An YJ, Kim HK, Kim SS, Park JK, Bae IH, Park DS, Shim JW, Kim JU, Kim NY, Kim SU, Lim KS, Jeong MH
- KMID: 2470312
- J Biomed Transl Res.
- 2019 Dec;20(4):91-98.
- doi: 10.12729/jbtr.2019.20.4.091
This study aimed to examine the effect of a mild elevation in serum cholesterol level in a porcine coronary overstretch restenosis model using a balloon angioplasty catheter or drug-eluting coronary... -
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- Increased CD68/TGFβ Co-expressing Microglia/Macrophages after Transient Middle Cerebral Artery Occlusion in Rhesus Monkeys
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Yeo HG, Hong JJ, Lee Y, Yi KS, Jeon CY, Park J, Won J, Seo J, Ahn YJ, Kim K, Baek SH, Hwang EH, Kim G, Jin YB, Jeong KJ, Koo BS, Kang P, Lim KS, Kim SU, Huh JW, Kim YH, Son Y, Kim JS, Choi CH, Cha SH, Lee SR
- KMID: 2458544
- Exp Neurobiol.
- 2019 Aug;28(4):458-473.
- doi: 10.5607/en.2019.28.4.458
The function of microglia/macrophages after ischemic stroke is poorly understood. This study examines the role of microglia/macrophages in the focal infarct area after transient middle cerebral artery occlusion (MCAO) in... -
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- Novel porcine model of acute myocardial infarction using polyethylene terephthalate
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Kim YS, Kim NY, Bae IH, Park JK, Park DS, Shim JW, Kang WS, Kim HB, Song BS, Koo BS, Jeong KJ, Kim SU, Kim HK, Kim SS, Kim MC, Sim DS, Hong YJ, Ahn Y, Lim KS, Jeong MH
- KMID: 2452876
- J Biomed Transl Res.
- 2019 Jun;20(2):44-52.
- doi: 10.12729/jbtr.2019.20.2.044
Acute myocardial infarction (AMI) is considered the major cause of mortality in the world. Tremendous animal studies are performed to develop novel therapeutics, and this study aimed to induce porcine... -
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- Abnormal Mitochondria in a Non-human Primate Model of MPTP-induced Parkinson's Disease: Drp1 and CDK5/p25 Signaling
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Park J, Seo J, Won J, Yeo HG, Ahn YJ, Kim K, Jin YB, Koo BS, Lim KS, Jeong KJ, Kang P, Lee HY, Baek SH, Jeon CY, Hong JJ, Huh JW, Kim YH, Park SJ, Kim SU, Lee DS, Lee SR, Lee Y
- KMID: 2451076
- Exp Neurobiol.
- 2019 Jun;28(3):414-424.
- doi: 10.5607/en.2019.28.3.414
Mitochondria continuously fuse and divide to maintain homeostasis. An impairment in the balance between the fusion and fission processes can trigger mitochondrial dysfunction. Accumulating evidence suggests that mitochondrial dysfunction is... -
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- Evaluation of fecal microbiomes associated with obesity in captive cynomolgus monkeys (Macaca fascicularis)
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Koo BS, Hwang EH, Kim G, Oh H, Son Y, Lee D, Lim KS, Kang P, Lee S, Lee HY, Jeong KJ, Lee Y, Baek SH, Jeon CY, Park SJ, Kim YH, Huh JW, Jin YB, Kim SU, Lee SR, Hong JJ
- KMID: 2448703
- J Vet Sci.
- 2019 May;20(3):e19.
- doi: 10.4142/jvs.2019.20.e19
Microorganisms play important roles in obesity; however, the role of the gut microbiomes in obesity is controversial because of the inconsistent findings. This study investigated the gut microbiome communities in... -
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- Influence of Local Myocardial Infarction on Endothelial Function, Neointimal Progression, and Inflammation in Target and Non-Target Vascular Territories in a Porcine Model of Acute Myocardial Infarction
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Kim HK, Kim HB, Lee JM, Kim SS, Bae IH, Park DS, Park JK, Shim JW, Na JY, Lee MY, Kim JS, Sim DS, Hong YJ, Nam CW, Doh JH, Park J, Koo BK, Kim SU, Lim KS, Jeong MH
- KMID: 2445803
- J Korean Med Sci.
- 2019 May;34(19):e145.
- doi: 10.3346/jkms.2019.34.e145
BACKGROUND: Patients with acute myocardial infarction (AMI) have worse clinical outcomes than those with stable coronary artery disease despite revascularization. Non-culprit lesions of AMI also involve more adverse cardiovascular events.... -
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- APACHE II Score Immediately after Cardiac Arrest as a Predictor of Good Neurological Outcome in Out-of-Hospital Cardiac Arrest Patients Receiving Targeted Temperature Management
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Kim SI, Kim YJ, Lee YJ, Ryoo SM, Sohn CH, Seo DW, Lee YS, Lee JH, Lim KS, Kim WY
- KMID: 2436315
- Acute Crit Care.
- 2018 May;33(2):83-88.
- doi: 10.4266/acc.2017.00514
BACKGROUND: This study assessed the association between the initial Acute Physiology and Chronic Health Evaluation (APACHE) II score and good neurological outcome in comatose survivors of out-of-hospital cardiac arrest who... -
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- Retrospective study of single vitrified-warmed blastocyst transfer cycles according to the presence of morphokinetic variables
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Hur YS, Ryu EK, Hyun CS, Yang SH, Yoon SH, Lim KS, Lee WD, Lim JH
- KMID: 2408578
- Clin Exp Reprod Med.
- 2018 Mar;45(1):52-55.
- doi: 10.5653/cerm.2018.45.1.52
This study retrospectively assessed whether time-lapse data relating to developmental timing and morphology were associated with clinical outcomes, with the eventual goal of using morphokinetic variables to select embryos prospectively... -
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- Post lumbar puncture headache: Case report of a serious adverse event in first-in-human study
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Shin W, Kim MK, Kim J, Woo MH, Cho DY, Lim KS
- KMID: 2406996
- Transl Clin Pharmacol.
- 2017 Dec;25(4):162-165.
- doi: 10.12793/tcp.2017.25.4.162
A lumbar puncture can be used to measure the concentrations of drugs and/or pharmacodynamic biomarkers during clinical trials of central nervous system drugs. We report a case of a post... -
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- Intramyocardial Injection of Stem Cells in Pig Myocardial Infarction Model: The First Trial in Korea
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Kim MC, Kim YS, Kang WS, Lee KH, Cho M, Hong MH, Lim KS, Jeong MH, Ahn Y
- KMID: 2400446
- J Korean Med Sci.
- 2017 Oct;32(10):1708-1712.
- doi: 10.3346/jkms.2017.32.10.1708
Although cell therapy is emerged for cardiac repair, its efficacy is modest by intracoronary infusion. Therefore, we established the intramyocardial delivery technique using a left ventricular (LV) mapping system (NOGA®... -
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- Rapid Collection of Opinions from Healthcare Professionals in Multiple Institutions Using Short Message Service and Google Forms
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Lee W, Shin SY, Seo DW, Sohn CH, Ryu JM, Lee JH, Kim WY, Oh BJ, Hong SO, Lim KS
- KMID: 2378522
- Healthc Inform Res.
- 2017 Apr;23(2):135-138.
- doi: 10.4258/hir.2017.23.2.135
No abstract available. -
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- Intravenous immunoglobulin G in women with reproductive failure: The Korean Society for Reproductive Immunology practice guidelines
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Sung N, Han AR, Park CW, Park DW, Park JC, Kim NY, Lim KS, Shin JE, Joo CW, Lee SE, Kim JW, Lee SK, IVIG Task Force, Korean Society for Reproductive Immunology
- KMID: 2408580
- Clin Exp Reprod Med.
- 2017 Mar;44(1):1-7.
- doi: 10.5653/cerm.2017.44.1.1
The task force of the Korean Society for Reproductive Immunology recommends intravenous immunoglobulin G treatment in women with reproductive failure, including recurrent pregnancy loss and/or repeated implantation failure, who show... -
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