Endocrinol Metab.  2017 Mar;32(1):124-128. 10.3803/EnM.2017.32.1.124.

Serum Preadipocyte Factor 1 Levels Are Not Associated with Bone Mineral Density among Healthy Postmenopausal Korean Women

• Choi HS
• Kim SW
• Cho EH

• KMID: 2413296
• DOI: http://doi.org/10.3803/EnM.2017.32.1.124

Abstract

BACKGROUND
Multipotent mesenchymal stem cells can differentiate into adipocytes or osteoblasts through closely regulated lineage-control processes. However, adipocyte precursor cells release preadipocyte factor 1 (Pref-1), which inhibits the differentiation of mesenchymal stem cells into mature adipocytes and osteoblasts. Previous studies have also reported an inverse association between Pref-1 levels and bone mineral density (BMD) among patients with anorexia nervosa.
METHODS
In this retrospective study, we examined the correlations between Pref-1 levels and BMD among 124 healthy postmenopausal women (>50 years old). The patients had provided information regarding their clinical characteristics, and underwent blood testing and serum Pref-1 testing.
RESULTS
The subjects' mean age was 59.9±7.1 years and the median time since menopause onset was 9.1 years. A history of osteoporotic fracture was identified in 23 subjects (19%). Serum Pref-1 levels were not significantly correlated with BMD values at the lumbar spine (R²=0.038, P=0.109), femur neck (R²=0.017, P=0.869), and total hip (R²=0.041, P=0.09), and multivariate analyses with adjustment for age and body mass index also did not detect any significant correlations. Subgroup analyses according to a history of fracture also did not detect significant associations between Pref-1 levels and BMD values.
CONCLUSION
In our study population, it does not appear that serum Pref-1 levels are significantly associated with BMD values and osteoporosis.

Keyword

Preadipocyte factor 1; Postmenopausal women; Bone density; Osteoporosis

MeSH Terms

Adipocytes
Anorexia Nervosa
Body Mass Index
Bone Density*
Female
Femur Neck
Hematologic Tests
Hip
Humans
Menopause
Mesenchymal Stromal Cells
Multivariate Analysis
Osteoblasts
Osteoporosis
Osteoporotic Fractures
Retrospective Studies
Spine