J Korean Med Sci.  2013 Oct;28(10):1496-1499. 10.3346/jkms.2013.28.10.1496.

High Serum Osteopontin Levels Are Associated with Low Bone Mineral Density in Postmenopausal Women

• Cho EH
• Cho KH
• Lee HA
• Kim SW

• KMID: 1777687
• DOI: http://doi.org/10.3346/jkms.2013.28.10.1496

Abstract

Osteopontin (OPN) is an acidic, noncollagenous matrix protein produced by the bone and kidneys. It is reportedly involved in bone resorption and formation. We examined the association between serum OPN levels and bone mineral density in postmenopausal women. Premenopausal women (n=32) and postmenopausal women (n=409) participated in the study. We measured serum osteopontin levels and their relationships with bone mineral density and previous total fragility fractures. The postmenopausal women had higher mean serum OPN levels compared to the premenopausal women (43.6+/-25.9 vs 26.3+/-18.6 ng/mL; P<0.001). In the postmenopausal women, high serum OPN levels were negatively correlated with mean lumbar bone mineral density (BMD) (r=-0.113, P=0.023). In a stepwise multiple linear regression model, serum OPN levels were associated with BMD of the spine, femoral neck, and total hip after adjustment for age, body mass index, smoking, and physical activity in postmenopausal women. However, serum OPN levels did not differ between postmenopausal women with and without fractures. Postmenopausal women exhibit higher serum OPN levels than premenopausal women and higher serum OPN levels were associated with low BMD in postmenopausal women.

Keyword

Bone Mineral Density; Postmenopause; Serum Osteopontin Levels; Fragility Fracture

MeSH Terms

Aged
Bone Density/*physiology
Female
Femur Neck/metabolism
Fractures, Bone/metabolism/pathology
Humans
Linear Models
Middle Aged
Osteopontin/*blood
Postmenopause
Premenopause
Spine/metabolism
Osteopontin