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Benefits of lumican on human bone health: clinical evidence using bone marrow aspirates

Lee YS, Park SJ, Lee JY, Choi E, Kim BJ

Background/Aims: Lumican, a small leucine-rich proteoglycan, has shown osteoprotective effects by synchronously stimulating bone formation and suppressing bone resorption. To clarify the role of lumican in human bone metabolism, the...
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Bone Mineral Density Screening Interval and Transition to Osteoporosis in Asian Women

Park H, Yang H, Heo J, Jang HW, Chung JH, Kim TH, Min YK, Kim SW

Background: Bone mineral density (BMD) testing is indicated for women aged 65 years, but screening strategies for osteoporosis are controversial. Currently, there is no study focusing on the BMD testing...
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Real-World Safety and Effectiveness of Denosumab in Patients with Osteoporosis: A Prospective, Observational Study in South Korea

Rhee Y, Chang DG, Ha J, Kim S, Lee Y, Jo E, Koh JM

Background: The efficacy and safety of denosumab have been established in a phase 3, randomized, placebo-controlled trial in Korean postmenopausal women with osteoporosis. This postmarketing surveillance study was aimed to...
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Correlation between gray values of cone-beam computed tomograms and Hounsfield units of computed tomograms: A systematic review and meta-analysis

Selvaraj A, Jain RK, Nagi R, Balasubramaniam A

Purpose The aim of this review was to systematically analyze the available literature on the correlation between the gray values (GVs) of cone-beam computed tomography (CBCT) and the Hounsfield units (HUs)...
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Bone Marrow Adiposity, Bone Mineral Density and Wnt/β-catenin Pathway Inhibitors Levels in Hemodialysis Patients

Wang YP, Khelifi N, Halleux Cd, Ung RV, Samson F, Gagnon C, Mac-Way F

Background: Marrow adipose tissue (MAT) is known to accumulate in patients with chronic kidney disease. This pilot study aimed to evaluate bone mineral density (BMD), MAT, visceral adipose tissue (VAT),...
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Moderate-Intensity Exercise Preserves Bone Mineral Density and Improves Femoral Trabecular Bone Microarchitecture in Middle-Aged Mice

Lee S, Shin YA, Cho J, Park DH, Kim C

Background: Aging leads to significant bone loss and elevated osteoporosis risk. Exercise slows age-related bone loss; however, the effects of various moderate-intensity exercise training volumes on bone metabolism remain unclear....
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The effect of fibroblast growth factor receptor inhibition on resistance exercise training-induced adaptation of bone and muscle quality in mice

Cho S, Lee H, Lee HY, Kim SJ, Song W

Aging in mammals, including humans, is accompanied by loss of bone and muscular function and mass, characterized by osteoporosis and sarcopenia. Although resistance exercise training (RET) is considered an effective intervention,...
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Metabolic Impacts of Discontinuation and Resumption of Recombinant Human Growth Hormone Treatment during the Transition Period in Patients with Childhood-Onset Growth Hormone Deficiency

Lee YJ, Choi Y, Yoo HW, Lee YA, Shin CH, Choi HS, Kim HS, Kim JH, Moon JE, Ko CW, Ahn MB, Suh BK, Choi JH

Background: Discontinuing growth hormone (GH) treatment during the transition to adulthood has been associated with adverse health outcomes in patients with childhood-onset growth hormone deficiency (CO-GHD). This study investigated the...
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Discontinuing Denosumab: Can It Be Done Safely? A Review of the Literature

Tay WL, Tay D

Denosumab, which has been approved for the treatment of osteoporosis since 2010, is a fully humanised monoclonal antibody against a cytokine, receptor activator of nuclear factor kappa B ligand (RANKL),...
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Effects of Combination Oral Contraceptives on Bone Mineral Density and Metabolism in Perimenopausal Korean Women

Kim SM, Shin W, Kim HJ, Lee JS, Min YK, Yoon BK

Objectives: A retrospective cohort study was conducted to evaluate the effects of combination oral contraceptives (COCs) on bone mineral density (BMD) and metabolism in perimenopausal Korean women. Methods: The study subjects...
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Investigation of the Factors Affecting Bone Mineral Density in Children with Celiac Disease

Dehghani SM, Ilkhanipour H, Samipour L, Niknam R, Shahramian I, Parooie F, Salarzaei M, Tahani M

Purpose: Children with celiac disease (CD) are at an increased risk of low bone mineral density (BMD) owing to malabsorption of fat-soluble vitamins, inflammation, and malnutrition. This study aimed to...
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Prevalence and Risk Factors of T-Score Spine-Hip Discordance in Patients with Osteoporotic Vertebral Compression Fracture

Yoon BH, Kang HW, Kim SM, Koh YD

Background: T-score discordance between the spine and hip is commonly observed when dual energy X-ray absorptiometry (DXA) is used to diagnose osteoporosis. However, information is scarce regarding the prevalence and...
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Comparison of cone-beam computed tomography and digital panoramic radiography for detecting peri-implant alveolar bone changes using trabecular micro-structure analysis

Magat G, Oncu E, Ozcan S, Orhan K

Objectives: We compared changes in fractal dimension (FD) and grayscale value (GSV) of peri-implant alveolar bone on digital panoramic radiography (DPR) and cone-beam computed tomography (CBCT) immediately after implant surgery...
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Statin Supply and Polydrug Use in Older Adults: A Focus on Drug Combinations that Reduce Bone Density

Ho J, Kim B, Kim KS, Jihn CH, Kim MY, Kang DR, Park YH, Ahn J

Background: We investigated the comorbidities of individuals who were prescribed statins to identify the use of bone mineral density (BMD)-reducing drugs, examine polydrug use trends involving these drugs, and explore...
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10-Year Fracture Risk in Postmenopausal Women with Osteopenia and Osteoporosis in South Korea

Baek YH, Cho SW, Jeong HE, Kim JH, Hwang Y, Lange JL, Shin JY

Background: In South Korea, women aged 66 years are eligible for complimentary bone mineral density (BMD) screening via the National Screening Program for Transitional Ages. We aimed to evaluate the...
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Changes in Serum Dickkopf-1, RANK Ligand, Osteoprotegerin, and Bone Mineral Density after Allogeneic Hematopoietic Stem Cell Transplantation Treatment

Jang E, Ha J, Baek KH, Kang MI

Background: Dickkopf-1 (DKK1) regulates bone formation by inhibiting canonical Wnt/β-catenin pathway signaling, and indirectly enhances osteoclastic activity by altering the expression ratio of receptor activator of nuclear factor-κB ligand (RANKL)...
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Assessment of the Bone Mineral Density and Microstructure of the Human Femoral Head according to Different Tip-apex Distances Can Guide the Treatment of Intertrochanteric Hip Fractures

Shen QH, Baik J, Won Y

Purpose: We analyzed the microstructure and bone mineral density (BMD) of the trabecular bone in the femoral head of patients with osteoporosis. Materials and Methods: Sixteen femoral heads with osteoporotic femoral...
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Understanding of Glucocorticoid Induced Osteoporosis

Son CN

Glucocorticoids are effective for many inflammatory diseases, but long-term use can lead to osteoporosis and resulting fractures. An initial evaluation of fracture risk should be done within six months of...
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Effect of Romosozumab on Trabecular Bone Score Compared to Anti-Resorptive Agents in Postmenopausal Women with Osteoporosis

Jeong C, Kim J, Lim Y, Ha J, Kang MI, Baek KH

Background: Romosozumab has shown significant improvement in bone mineral density (BMD) in previously reported trials. However, BMD reflects only bone strength and does not offer insight into the bone microarchitecture....
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Effects of the Lysine Methyltransferase Inhibitor AZ505 on Bone Metabolism

Song MK, Jung S, Hong S, Kwon JO, Kim MK, Kim HH

Background: Protein methylation has important role in regulating diverse cellular responses, including differentiation, by affecting protein activity, stability, and interactions. AZ505 is an inhibitor of the SET and MYND domain-containing...
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