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Evaluation of Drug-Induced Liver Injury Developed During Hospitalization Using Electronic Health Record (EHR)-Based Algorithm

Kang Y, Kim SH, Park SY, Park BY, Lee JH, An J, Won HK, Song WJ, Kwon HS, Cho YS, Moon HB, Shim JH, Yang MS, Kim TB

PURPOSE: The incidence of drug-induced liver injury (DILI) has been increasing; however, few algorithms are available to identify DILI in electronic health records (EHRs). We aimed to identify and evaluate...
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Alzheimer's Disease Diagnosis Using Misfolding Proteins in Blood

Lee H, Ugay D, Hong S, Kim Y

Alzheimer's disease (AD) is pathologically characterized by a long progressive phase of neuronal changes, including accumulation of extracellular amyloid-β (Aβ) and intracellular neurofibrillary tangles, before the onset of observable symptoms....
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Can Calprotectin Show Subclinical Inflammation in Familial Mediterranean Fever Patients?

Asan G, Derin ME, DoÄŸan HO, Bayram M, Åžahin M, Åžahin A

BACKGROUND: Familial Mediterranean fever (FMF) is an autoinflammatory disease that has self-limiting inflammatory attacks during polyserositis. Hepcidin is a protein, and interleukin-6 stimulation increases hepcidin levels. Calprotectin (CLP) is a...
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Clinical Score System to Differentiate Severe Fever with Thrombocytopenia Syndrome Patients from Patients with Scrub Typhus or Hemorrhagic Fever with Renal Syndrome in Korea

Heo DH, Kang YM, Song KH, Seo JW, Kim JH, Chun JY, Jun KI, Kang CK, Moon SM, Choe PG, Park WB, Bang JH, Kim ES, Kim HB, Park SW, Oh WS, Kim NJ, Oh MD

BACKGROUND: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease with high mortality in East Asia. This study aimed to develop, for primary care providers, a prediction score...
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Bilateral Acute Angle Closure Attack and Choroidal Detachment in Patient with Acquired Immune Deficiency Syndrome

Park KH, Lee JJ, Lee JW, Lee JE

PURPOSE: To report a case of simultaneous bilateral acute angle closure attack combined with bilateral choroidal detachment in a patient with acquired immune deficiency syndrome (AIDS). CASE SUMMARY: A 63-year-old male...
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Comparison of Clinical Characteristics between Patients with Cytomegalovirus Positive and Negative Hypertensive Uveitis

Kim JH, Lee JY, Choi JA

PURPOSE: To compare the clinical characteristics of hypertensive uveitis patients, with and without cytomegalovirus (CMV) infection. METHODS: CMV polymerase chain reaction (PCR) was performed on the aqueous humor of 61 patients...
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A prospective study of discrepancy between clinical and pathological diagnosis of appendiceal mucinous neoplasm

Kwak HD, Ju JK

PURPOSE: Appendiceal tumoral lesions can occur as benign, malignant, or borderline disease. Determination of the extent of surgery through accurate diagnosis is important in these tumoral lesions. In this study,...
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Clinical characteristics of allergic rhinitis and nonallergic rhinitis in Korean children

Won NH, Park SH, Ahn SH, Kim CB, Kwon JH, Seo WH, Song DJ, Yoo Y

PURPOSE: Recently, the prevalence of allergic rhinitis (AR) in Korean children has been increased. The aim of this study was to investigate the clinical characteristics of rhinitis and to compare...
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Age-specific variations in hematological and biochemical parameters in middle- and large-sized of dogs

Lee SH, Kim JW, Lee BC, Oh HJ

Aging triggers cellular and molecular alterations, including genomic instability and organ dysfunction, which increases the risk of disease in mammals. Recently, due to the markedly growing number of aging dogs...
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Arterial stiffness in young women with Turner syndrome using cardio-ankle vascular index

Heo YJ, Jung HW, Lee YA, Shin CH, Yang SW

PURPOSE: Patients with Turner syndrome (TS) have increased risk of morbidities and mortality related to cardiovascular complications. Cardio-ankle vascular index (CAVI) is a novel method of evaluating arterial stiffness independent...
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Prognostic Value of Serum Procalcitonin level for the Diagnosis of Bacterial Infections in Critically-ill Patients

So-Ngern A, Leelasupasri S, Chulavatnatol S, Pummangura C, Bunupuradah P, Montakantikul P

BACKGROUND: Procalcitonin (PCT) is a diagnostic biomarker for bacterial infections in critically-ill patients. However, the cut-off value of PCT for the diagnosis of bacterial infections is unclear and unreliable. This...
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Sex Difference in the Effect of Body Mass Index and Stress on High-Risk Diabetes Mellitus in Korean Adults

Lee HS

PURPOSE: This study aimed to investigate sex differences in the effect of body mass index (BMI) and stress on high-risk diabetes mellitus (DM). METHODS: Secondary analysis of data from 4,271 male...
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Association Between High Neutrophil to Lymphocyte Ratio and Delayed Recovery From Bell's Palsy

Kim HS, Jung J, Dong SH, Kim SH, Jung SY, Yeo SG

OBJECTIVES: Factors predictive of the severity of and recovery from Bell's palsy remain unclear. This study evaluated the association between neutrophil to lymphocyte ratio (NLR) and the severity of and...
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Can Elderly Patients with Severe Mitral Regurgitation Benefit from Trans-catheter Mitral Valve Repair?

Lee CW, Sung SH, Huang WM, Tsai YL, Chen HY, Hsu CP, Shih CC, Chung KP

BACKGROUND AND OBJECTIVES: Age is a traditional risk factor for open-heart surgery. The efficacy and safety of transcatheter edge-to-edge mitral valve repair, using MitraClip (Abbott Vascular), has been demonstrated in...
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Temporal and Geospatial Trends of Hypertension Management in Korea: a Nationwide Study 2002–2016

Lee H, Park S, Kim HC

BACKGROUND AND OBJECTIVES: Geographic distribution of hypertension management in Korea has never been reported. We investigated temporal and regional trends of hypertension management in Korea. METHODS: For each calendar year from...
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Characteristics of blood tests in patients with acute cerebral infarction who developed symptomatic intracranial hemorrhage after intravenous administration of recombinant tissue plasminogen activator

Lee C, Na JU, Lee JH, Han SK, Choi PC, Lee YH, Park SO, Shin DH

OBJECTIVE: Patients suspected as having acute ischemic stroke usually undergo blood tests, including coagulation-related indexes, because thrombocytopenia and coagulopathy are contraindications for recombinant tissue plasminogen activator (rtPA) administration. We aimed...
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A Case of Treatment with QRS Widening in Electrocardiogram after Glyphosate Herbicide Poisoning

Lee JH

Glyphosate herbicides, which are widely used worldwide, are known to have low toxicity. However, excessive intake may cause serious life-threatening complications; therefore, caution is needed when using them. A 51-year-old...
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Unusual Semimembranosus Muscle Metastasis from Hepatocellular Carcinoma

Kim SH, Kim MW, Kim JH, Wang L

Hepatocellular carcinoma is one of the most common cancers worldwide. Extrahepatic metastasis commonly occur in the lung, lymph, nodes, bone, and adrenal glands. On the other hand, a metastasis of...
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Usefulness of initial red blood cell distribution width as a prognostic factor for predicting 30-day mortality in acute decompensated heart failure patients

Ahn TK, Ham EM, Pyo CH, Choi HJ, Park SH, Park KH, Kim HB, Oh SH

OBJECTIVE: This study evaluated the efficacy of the initial red blood cell distribution width (RDW) level in the emergency department (ED) to predict the 30-day mortality in patients with acute...
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Albumin-Bilirubin Score Predicts Tolerability to Adjuvant S-1 Monotherapy after Curative Gastrectomy

Miwa T, Kanda M, Tanaka C, Kobayashi , Hayashi M, Yamada S, Nakayama G, Koike M, Kodera Y

PURPOSE: Due to adverse events, dose reduction or withdrawal of adjuvant chemotherapy is required for some patients. To identify the predictive factors for tolerability to postoperative adjuvant S-1 monotherapy in...
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