J Korean Neurol Assoc.  1996 Jun;14(2):538-542.

Association of Apolipoprotein E Genotypes with Late-onset Alzheimer's Disease in Korea

• Lee YS
• Na DL
• Kim JW

Abstract

Apolipoprotein E-epsilon4(APOE4) is recently known as a susceptibility gene or risk factor associated with late-onset Alzheimer's disease (AD). Association between APOE4 and probable AD was determined in Korean population. Twenty patients met the NINCDS-ADRDA probable AD criteria (M:F=7:13, Mean age: 70.1 yr)were compared with 146 controls without dementia (M:F=83:63, Mean age:63.6 yr). APOE genotype was determined by polymerase chain reaction and allele specific hybridization technique. APOE4 allele frequency (0.33 vs. 0.11, p<.01) and proportion of carriers with APOE4(60% vs. 19%, p<.01) were significantly increased in patient group. APOE4 genotype is also associated with late-onset sporadic AD in Korean, and APOE genotyping may be useful for differential diagnosis of AD for patients with dementia.

MeSH Terms

Alleles
Alzheimer Disease*
Apolipoprotein E4
Apolipoproteins E
Apolipoproteins*
Dementia
Diagnosis, Differential
Gene Frequency
Genotype*
Humans
Korea*
Polymerase Chain Reaction
Risk Factors
Apolipoprotein E4
Apolipoproteins
Apolipoproteins E