- IntraBrain Injector (IBI): A StereotacticGuided Device for Repeated Delivery of Therapeutic Agents Into the Brain Parenchyma
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Lee J, Lee S, Jung W, Kim GB, Kim T, Seong J, Jang H, Noh Y, Lee NK, Lee BR, Lee JI, Choi SJ, Oh W, Kim N, Lee S, Na DL
- KMID: 2532319
- J Korean Med Sci.
- 2022 Aug;37(31):e244.
- doi: 10.3346/jkms.2022.37.e244
Background: To deliver therapeutics into the brain, it is imperative to overcome the issue of the blood-brain-barrier (BBB). One of the ways to circumvent the BBB is to administer therapeutics... -
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- [ 18 F]THK-5351 PET Patterns in Patients With Alzheimer’s Disease and Negative Amyloid PET Findings
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Oh M, Oh JS, Oh SJ, Lee SJ, Roh JH, Kim WR, Seo HE, Kang JM, Seo SW, Lee JH, Na DL, Noh Y, Kim JS
- KMID: 2530845
- J Clin Neurol.
- 2022 Jul;18(4):437-446.
- doi: 10.3988/jcn.2022.18.4.437
Background and Purpose Alzheimer’s disease (AD) does not always mean amyloid positivity. [ 18 F]THK-5351 has been shown to be able to detect reactive astrogliosis as well as tau accompanied... -
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- 18F-THK5351 PET Positivity and Longitudinal Changes in Cognitive Function in β-Amyloid-Negative Amnestic Mild Cognitive Impairment
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Chun MY, Lee J, Jeong JH, Roh JH, Oh SJ, Oh M, Oh JS, Kim JS, Moon SH, Woo Sy, Kim YJ, Choe YS, Kim HJ, Na DL, Jang H, Seo SW
- KMID: 2526558
- Yonsei Med J.
- 2022 Mar;63(3):259-264.
- doi: 10.3349/ymj.2022.63.3.259
Purpose: Neuroinflammation is considered an important pathway associated with several diseases that result in cognitive decline. 18F-THK5351 positron emission tomography (PET) signals might indicate the presence of neuroinflammation, as well... -
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- Developing a Dementia Platform Databank Using Multiple Existing Cohorts
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Kang M, Cheon BK, Hahn MJ, Seo SW, Cho J, Shin SY, Na DL, Cho J, Choi SH, Kang D
- KMID: 2521457
- Yonsei Med J.
- 2021 Nov;62(11):1062-1068.
- doi: 10.3349/ymj.2021.62.11.1062
This study was conducted as a pilot project to evaluate the feasibility of building an integrate dementia platform converging preexisting dementia cohorts from several variable levels. The following four cohorts... -
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- Cerebrospinal Fluid Biomarkers for the Diagnosis and Classification of Alzheimer's Disease Spectrum
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Lee Jm, Jang Hm, Kang SH, Kim J, Kim JS, Kim JP, Kim HJ, Seo SW, Na DL
- KMID: 2508763
- J Korean Med Sci.
- 2020 Nov;35(44):e361.
- doi: 10.3346/jkms.2020.35.e361
Background: Cerebrospinal fluid (CSF) biomarkers are increasingly used in clinical practice for the diagnosis of Alzheimer's disease (AD). We aimed to 1) determine cutoff values of CSF biomarkers for AD,... -
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- A Validation Study of the Inbrain CST: a Tablet Computer-based Cognitive Screening Test for Elderly People with Cognitive Impairment
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Chin J, Kim DE, Lee H, Yun J, Lee BH, Park J, Yeom J, Shin DS, Na DL
- KMID: 2505723
- J Korean Med Sci.
- 2020 Aug;35(34):e292.
- doi: 10.3346/jkms.2020.35.e292
Background: Computerized versions of cognitive screening test could have advantages over pencil-and-paper versions by eliminating rater-dependent factors and saving the time required to score the tests and report the results.... -
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- [18F]THK5351 PET Imaging in Patients with Mild Cognitive Impairment
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Jeong HJ, Lee H, Lee SY, Seo S, Park KH, Lee YB, Shin DJ, Kang JM, Yeon BK, Kang SG, Cho J, Seong JK, Okamura N, Villemagne VL, Na DL, Noh Y
- KMID: 2506811
- J Clin Neurol.
- 2020 Apr;16(2):202-214.
- doi: 10.3988/jcn.2020.16.2.202
Background and Purpose Mild cognitive impairment (MCI) is a condition with diverse clinical outcomes and subgroups. Here we investigated the topographic distribution of tau in vivo using the positron emission tomography... -
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- A Comparison Study of Cilostazol and Aspirin on Changes in Volume of Cerebral Small Vessel Disease White Matter Changes: Protocol of a Multicenter, Randomized Controlled Trial
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Han HJ, Kim BC, Youn YC, Jeong JH, Kim JH, Lee JH, Park KH, Park KW, Kim EJ, Oh MS, Shim YS, Park HY, Yoon B, Yoon SJ, Cho SJ, Park KC, Na DL, Park SA, Lee JM, Choi SH
- KMID: 2466757
- Dement Neurocogn Disord.
- 2019 Dec;18(4):138-148.
- doi: 10.12779/dnd.2019.18.4.138
BACKGROUND AND PURPOSE: Cerebral small vessel disease (CSVD) is the most common cause of vascular dementia and a major contributor to mixed dementia. CSVD is characterized by progressive cerebral white... -
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- The Cortical Neuroanatomy Related to Specific Neuropsychological Deficits in Alzheimer's Continuum
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Kang SH, Park YH, Lee D, Kim JP, Chin J, Ahn Y, Park SB, Kim HJ, Jang H, Jung YH, Kim J, Lee J, Kim JS, Cheon BK, Hahn A, Lee H, Na DL, Kim YJ, Seo SW
- KMID: 2461049
- Dement Neurocogn Disord.
- 2019 Sep;18(3):77-95.
- doi: 10.12779/dnd.2019.18.3.77
BACKGROUND AND PURPOSE: In Alzheimer's continuum (a comprehensive of preclinical Alzheimer's disease [AD], mild cognitive impairment [MCI] due to AD, and AD dementia), cognitive dysfunctions are often related to cortical... -
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- The First Generation of iPSC Line from a Korean Alzheimer's Disease Patient Carrying APP-V715M Mutation Exhibits a Distinct Mitochondrial Dysfunction
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Li L, Roh JH, Kim HJ, Park HJ, Kim M, Koh W, Heo H, Chang JW, Nakanishi , Yoon T, Na DL, Song J
- KMID: 2451069
- Exp Neurobiol.
- 2019 Jun;28(3):329-336.
- doi: 10.5607/en.2019.28.3.329
Alzheimer's Disease (AD) is a progressive neurodegenerative disease, which is pathologically defined by the accumulation of amyloid plaques and hyper-phosphorylated tau aggregates in the brain. Mitochondrial dysfunction is also a... -
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- Risk Factors of Behavioral and Psychological Symptoms in Patients with Alzheimer Disease: The Clinical Research of Dementia of South Korea Study
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Park S, Kim DK, Myung W, Yoo JH, Shin SJ, Na DL, Kim SY, Lee JH, Kim SY, Han SH, Choi SH, Shin J
- KMID: 2431619
- Korean J Fam Med.
- 2019 Jan;40(1):16-21.
- doi: 10.4082/kjfm.17.0061
BACKGROUND: Few studies have evaluated risk factors for behavioral and psychological symptoms of dementia at the initial assessment for Alzheimer disease in large patient samples. In this study, the factors... -
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- Subcortical Ischemic Change as a Predictor of Driving Cessation in the Elderly
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Jang M, Hong CH, Kim HC, Choi SH, Seo SW, Kim SY, Na DL, Lee Y, Chang KJ, Roh HW, Son SJ
- KMID: 2434765
- Psychiatry Investig.
- 2018 Dec;15(12):1162-1167.
- doi: 10.30773/pi.2018.10.10.3
OBJECTIVE: Motor, perceptual, and cognitive functions are known to affect driving competence. Subcortical ischemic changes on brain magnetic resonance imaging (MRI) can reflect reduction in cognitive and motor performance. However,... -
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- The Brain Donation Program in South Korea
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Kim Y, Suh YL, Kim SJ, Bae MH, Kim JB, Kim Y, Choi KC, Huh GY, Kim EJ, Lee JS, Kang HW, Shim SM, Lim HJ, Koh YH, Kim BC, Lee KH, Lee MC, Lee HW, Lim TS, Seeley WW, Kim HJ, Na DL, Lee KH, Seo SW
- KMID: 2426334
- Yonsei Med J.
- 2018 Dec;59(10):1197-1204.
- doi: 10.3349/ymj.2018.59.10.1197
PURPOSE: Obtaining brain tissue is critical to definite diagnosis and to furthering understanding of neurodegenerative diseases. The present authors have maintained the National Neuropathology Reference and Diagnostic Laboratories for Dementia... -
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- iPSC Modeling of Presenilin1 Mutation in Alzheimer's Disease with Cerebellar Ataxia
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Li L, Roh JH, Chang EH, Lee Y, Lee S, Kim M, Koh W, Chang JW, Kim HJ, Nakanishi , Barker RA, Na DL, Song J
- KMID: 2424730
- Exp Neurobiol.
- 2018 Oct;27(5):350-364.
- doi: 10.5607/en.2018.27.5.350
Disease modeling of Alzheimer's disease (AD) has been hampered by the lack of suitable cellular models while animal models are mainly based on the overexpression of AD-related genes which often... -
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- National Responsibility Policy for Dementia Care: Current and Future
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Choi H, Kim SH, Lee JH, Lee AY, Park KW, Lee EA, Choi SH, Na DL, Jeong JH
- KMID: 2436069
- J Korean Neurol Assoc.
- 2018 Aug;36(3):152-158.
- doi: 10.17340/jkna.2018.3.3
With the world's fastest-growing aged population, dementia care has become a major public health concern in Korea, prompting the emergence of the policy of national responsibility for dementia care. Over... -
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- Pathologically Confirmed Cerebral Amyloid Angiopathy with No Radiological Sign in a Patient with Early Onset Alzheimer's Disease
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Kim SJ, Seo Y, Kim HJ, Na DL, Seo SW, Kim Y, Suh YL
- KMID: 2415541
- Yonsei Med J.
- 2018 Aug;59(6):801-805.
- doi: 10.3349/ymj.2018.59.6.801
Cerebral amyloid angiopathy (CAA) is associated with perivascular disruption, which is caused by progressive amyloid-beta (Aβ) deposition in vessels. Previous autopsy studies have shown that the prevalence of CAA in... -
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- Age-Specific Cutoff Scores on a T1-Weighted Axial Medial Temporal-Lobe Atrophy Visual Rating Scale in Alzheimer's Disease Using Clinical Research Center for Dementia of South Korea Data
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Choi GS, Kim GH, Choi JH, Hwang J, Kwon E, Lee SA, Kong KA, Kang HJ, Yoon B, Kim BC, Yang DW, Na DL, Kim EJ, Na HR, Han HJ, Lee JH, Kim JH, Lee KY, Park KH, Park KW, Kim S, Han SH, Kim SY, Yoon SJ, Moon SY, Youn YC, Choi SH, Jeong JH
- KMID: 2415041
- J Clin Neurol.
- 2018 Jul;14(3):275-282.
- doi: 10.3988/jcn.2018.14.3.275
BACKGROUND AND PURPOSE: Visual assessment of medial temporal-lobe atrophy (MTA) has been quick, reliable, and easy to apply in routine clinical practice. However, one of the limitations in visual assessments... -
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- Increased Uptake of AV-1451 in a Subacute Infarction Lesion
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Cho SH, Cho H, Park S, Ryu YH, Choi JY, Lyoo CH, Na DL, Seo SW, Kim HJ
- KMID: 2410912
- Yonsei Med J.
- 2018 Jun;59(4):563-565.
- doi: 10.3349/ymj.2018.59.4.563
¹â¸F-AV-1451 is a tau PET ligand that has high affinity for paired helical filament tau. However, various off-target bindings unrelated to tau have also been reported. Herein, we report a... -
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- Predictors of Institutionalization in Patients with Alzheimer's Disease in South Korea
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Park DG, Lee S, Moon YM, Na DL, Jeong JH, Park KW, Lee YH, Lim TS, Choi SH, Moon SY
- KMID: 2407946
- J Clin Neurol.
- 2018 Apr;14(2):191-199.
- doi: 10.3988/jcn.2018.14.2.191
BACKGROUND AND PURPOSE: We investigated predictors of institutionalization in patients with Alzheimer's disease (AD) in South Korea. METHODS: In total, 2,470 patients with AD aged 74.5±7.8 years (mean±standard deviation, 68.1% females)... -
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- Medial-Vowel Writing Difficulty in Korean Syllabic Writing: A Characteristic Sign of Alzheimer's Disease
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Yoon JH, Jeong Y, Na DL
- KMID: 2407944
- J Clin Neurol.
- 2018 Apr;14(2):179-185.
- doi: 10.3988/jcn.2018.14.2.179
BACKGROUND AND PURPOSE: Korean-speaking patients with a brain injury may show agraphia that differs from that of English-speaking patients due to the unique features of Hangul syllabic writing. Each grapheme... -
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