J Korean Soc Biol Psychiatry.  2003 Nov;10(2):116-120.

Genetic Polymorphisms of Apolipoprotein E in Korean Schizophrenic Patients

• Cho GH
• Chung SG
• Hwang IK

Abstract

OBJECTIVES
Although polymorphisms of apolipoprotein E have been investigated in many neuropsychiatric disorders, results were controversial and even contradictory. The purpose of this study was to investigate the genotypes of apolipoprotein E in schizophrenia and healthy controls, and to compare them in two groups in terms of distribution of apolipoprotein E genotype and allele. METHOD: Using polymerase chain reaction and amplified refractory mutation system, apolipoprotein E genotypes were identified in 77 schizophrenics and 115 healthy control persons.
RESULTS
The results were as follows 1) When genotypes of apolipoprotein E were classified into epsilon2/2, epsilon2/3, epsilon2/4, epsilon3/3, epsilon3/4, epsilon4/4 according to phenotypes, there were no statistical differences in genotypes between two groups 2) In terms of allele frequency, there were also no statistical differences between two groups
CONCLUSION
These results suggest that genotypes and alleles of apolipoprotein E seem to be unrelated to the pathogenesis of schizophrenia.

MeSH Terms

Alleles
Apolipoproteins*
Gene Frequency
Genotype
Humans
Phenotype
Polymerase Chain Reaction
Polymorphism, Genetic*
Schizophrenia
Apolipoproteins