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The R278I Mutation of PSEN1 in the Familial Alzheimer Disease

Kim JH, Choi SH, Lee JH

No abstract available.
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The Impact of Comorbid Alzheimer's Disease in a Patient with Normal Pressure Hydrocephalus?

Onder H

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Alzheimer's Disease Diagnosis Using Misfolding Proteins in Blood

Lee H, Ugay D, Hong S, Kim Y

Alzheimer's disease (AD) is pathologically characterized by a long progressive phase of neuronal changes, including accumulation of extracellular amyloid-β (Aβ) and intracellular neurofibrillary tangles, before the onset of observable symptoms....
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Association of Nutritional Status with Cognitive Stage in the Elderly Korean Population: The Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer's Disease

Jang JW, Kim Y, Choi YH, Lee JM, Yoon B, Park KW, Kim SE, Kim HJ, Yoon SJ, Jeong JH, Kim EJ, Jung NY, Hwang J, Kang JH, Hong JY, Choi SH

BACKGROUND AND PURPOSE: Epidemiological studies have suggested the presence of strong correlations among diet, lifestyle, and dementia onset. However, these studies have unfortunately had major limitations due to their inability...
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Long Noncoding RNA NEAT1 Aggravates Aβ-Induced Neuronal Damage by Targeting miR-107 in Alzheimer's Disease

Ke S, Yang Z, Yang F, Wang X, Tan J, Liao B

PURPOSE: Alzheimer's disease (AD) is the most common neurodegenerative disease, with a rising prevalence worldwide. Long noncoding RNAs (lncRNAs) have been found to play important roles in the development and...
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Association between Thyroid-Related Hormones and Cognitive Function in Patients with Alzheimer's Disease and Mild Cognitive Impairment

Park DY, Kim H, Lee KJ

OBJECTIVES: The association between thyroid-related hormones and cognitive function has been controversial. The purpose of this study is to compare the levels of thyroid-related hormones in patients with Alzheimer's disease...
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Memantine Improves Cognitive Function and Alters Hippocampal and Cortical Proteome in Triple Transgenic Mouse Model of Alzheimer's Disease

Zhou X, Wang L, Xiao W, Su Z, Zheng C, Zhang Z, Wang Y, Xu B, Yang X, Hoi MP

Memantine is a non-competitive N-methyl-D-aspartate receptor (NMDAR) antagonist clinically approved for moderate-to-severe Alzheimer's disease (AD) to improve cognitive functions. There is no report about the proteomic alterations induced by memantine...
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Metabolomic Analysis Identifies Alterations of Amino Acid Metabolome Signatures in the Postmortem Brain of Alzheimer's Disease

Kim YH, Shim HS, Kim KH, Lee J, Chung BC, Kowall NW, Ryu H, Lee J

Despite significant advances in neuroscience research over the past several decades, the exact cause of AD has not yet fully understood. The metabolic hypothesis as well as the amyloid and...
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The First Generation of iPSC Line from a Korean Alzheimer's Disease Patient Carrying APP-V715M Mutation Exhibits a Distinct Mitochondrial Dysfunction

Li L, Roh JH, Kim HJ, Park HJ, Kim M, Koh W, Heo H, Chang JW, Nakanishi , Yoon T, Na DL, Song J

Alzheimer's Disease (AD) is a progressive neurodegenerative disease, which is pathologically defined by the accumulation of amyloid plaques and hyper-phosphorylated tau aggregates in the brain. Mitochondrial dysfunction is also a...
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A Therapeutic Strategy for Alzheimer's Disease Focused on Immune-inflammatory Modulation

Kim SH, Noh MY, Kim HJ, Oh KW, Park J, Lee S, Moon Y, Kim YE, Bae JS, Jin HK, K-ARPI

Alzheimer's disease (AD), the most common form of dementia, has emerged as a major global public health challenge. However, the complexity of AD in its biological, genetic, and clinical aspects...
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Assessment of Cognitive Phenotyping in Inbred, Genetically Modified Mice, and Transgenic Mouse Models of Alzheimer's Disease

Kim DH, Jang YS, Jeon WK, Han JS

Genetically modified mouse models are being used predominantly to understand brain functions and diseases. Well-designed and controlled behavioral analyses of genetically modified mice have successfully led to the identification of...
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Newly Diagnosed Sarcopenia and Alzheimer's Disease in an Older Patient With Chronic Inflammation

Kim SH, Sin DS, Lim JY

A 78-year-old man presented with the aggravation of weakness in the lower extremities, gait disturbance, and cognitive impairment. He was diagnosed with sarcopenia, distal sensorimotor polyneuropathy, and Alzheimer's disease. Low-grade...
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A Comparison of Memory Beliefs, Cognitive Activity, and Depression Among Healthy Older Adults, Amnestic Mild Cognitive Impairment, and Patient with Alzheimer's Disease

Park J, Im JJ, Song IU, Kang Y

BACKGROUND: Amnestic mild cognitive impairment (aMCI) is highly likely to progress to dementia of the Alzheimer type (DAT). One of the most frequently reported symptoms in aMCI and DAT patients...
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A New Biological Definition of Alzheimer's Disease: Introduction of 2018 National Institute on Aging-Alzheimer's Association Research Framework

Jang JW, Kim S

Diagnostic guidelines for the preclinical, mild cognitive impairment, and dementia stages of Alzheimer's disease (AD) were released by the National Institute on Aging and Alzheimer's Association (NIA-AA) in 2011. Promoted...
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Dysfunctional Mitochondrial Bioenergetics and Synaptic Degeneration in Alzheimer Disease

Tang J, Oliveros A, Jang MH

Synapses are sites of high energy demand which are dependent on high levels of mitochondrial derived adenosine triphosphate. Mitochondria within synaptic structures are key for maintenance of functional neurotransmission and...
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Adzuki bean (Vigna angularis) extract reduces amyloid-β aggregation and delays cognitive impairment in Drosophila models of Alzheimer's disease

Miyazaki H, Okamoto Y, Motoi A, Watanabe T, Katayama S, Kawahara S, Makabe H, Fujii H, Yonekura S

BACKGROUND/OBJECTIVES: Alzheimer's disease is a neurodegenerative disease that induces symptoms such as a decrease in motor function and cognitive impairment. Increases in the aggregation and deposition of amyloid beta protein...
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Association between Cognitive function, Behavioral and Psychological Symptoms of Dementia and Temporal Lobe Atrophy in Patients with Alzheimer's Disease and Mild Cognitive Impairment

Jeong JY, Lee KJ, Kim H

OBJECTIVES: The aim of this study was to compare severity, neurocognitive functions, and behavioral and psychological symptoms of dementia (BPSD) according to the degree of temporal lobe atrophy (MTA) in...
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The Prevalence of Rapid Eye Movement Sleep Behavior Disorder in Amyloid Positron Emission Tomography Positive Alzheimer's Disease

Kim HS, Lee HJ, Shin DJ, Lee YB, Noh Y, Park KH

OBJECTIVES: Rapid eye movement (REM) sleep behavior disorder (RBD) is well known as a prodromal symptom of neurodegenerative disease, especially α-synucleinopathy. In the previous literature, it has been reported the...
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Regulation of Diabetes: a Therapeutic Strategy for Alzheimer's Disease?

Ahn KC, Learman CR, Baker GB, Weaver CL, Chung PS, Kim HG, Song MS

Accumulated evidence suggests that sporadic cases of Alzheimer's disease (AD) make up more than 95% of total AD patients, and diabetes has been implicated as a strong risk factor for...
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Cellular and Molecular Mediators of Neuroinflammation in Alzheimer Disease

Yang SH

Alzheimer disease (AD) is a neurodegenerative disorder characterized by the loss of neuronal cells and the progressive decline of cognitive function. The major pathological culprit of AD is aggregation of...
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