Ann Pediatr Endocrinol Metab.  2016 Jun;21(2):61-65. 10.6065/apem.2016.21.2.61.

Regulation of exercise-stimulated glucose uptake in skeletal muscle

• Koh HJ

• KMID: 2328142
• DOI: http://doi.org/10.6065/apem.2016.21.2.61

Abstract

AMP-activated protein kinase (AMPK) is a Ser/Thr kinase that has been thought to be an important mediator for exercise-stimulated glucose uptake in skeletal muscle. Liver kinase B1 (LKB1) is an upstream kinase for AMPK and AMPK-related protein kinases, of which the function in skeletal muscle has not been well documented. Our group and others have generated mice lacking AMPK activity in skeletal muscle, as well as muscle-specific LKB1 knockout mice. In this review, we discuss the potential role of AMPK and LKB1 in regulating exercise-stimulated glucose uptake in skeletal muscle. We also discuss our recent study, demonstrating the molecular mechanism of obesity-induced development of skeletal muscle insulin resistance.

Keyword

Skeletal muscle; Glucose uptake; Exercise; Obesity; Insulin

MeSH Terms

AMP-Activated Protein Kinases
Animals
Glucose*
Insulin
Insulin Resistance
Liver
Mice
Mice, Knockout
Muscle, Skeletal*
Obesity
Phosphotransferases
Protein Kinases
AMP-Activated Protein Kinases
Glucose
Insulin
Phosphotransferases
Protein Kinases

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