- The Development of NKT Cells in Thymus is Defective in CD45 Knockout Mice
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Jung DH, Margulies
- KMID: 1573065
- Korean J Immunol.
- 2000 Sep;22(3):117-121.
No abstract available. -
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- The effect of oxygen on retinal degeneration in wild-type and hsp70.1 knockout neonatal retinal degeneration mice
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Choi MY, Yu YS, Kim SK, Kim YJ, Seo JS
- KMID: 754285
- Korean J Ophthalmol.
- 2001 Jun;15(1):1-7.
- doi: 10.3341/kjo.2001.15.1.1
The present study examined the effect of oxygen on photoreceptor degeneration in the retina of heat shock protein 70.1 (hsp70.1) knockout type and wild-type retinal degeneration (rd) mice. All the... -
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- Expression of Aquaporin-3 and Aquaporin-4 in Aquaporin-1 Knockout Mice
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Kim WY, Kim YH, Park EY, Hwang JS, Kim YM, Kim J
- KMID: 2092939
- Korean J Anat.
- 2008 Sep;41(3):163-172.
Recent studies demonstrated impaired urinary concentrating ability in AQP1 knockout mice. To establish of the lack of AQP1 was associated with compensatory changes in other aquaporins, we examined the expression... -
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- Expression of pancreatic and duodenal homeobox1 (PDX1) protein in the interior and exterior regions of the intestine, revealed by development and analysis of Pdx1 knockout mice
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Hashimoto , Kamisako T, Kagawa T, Haraguchi , Yagoto M, Takahashi , Kawai K, Suemizu H
- KMID: 2053683
- Lab Anim Res.
- 2015 Jun;31(2):93-98.
- doi: 10.5625/lar.2015.31.2.93
We developed pancreatic and duodenal homeobox1 (Pdx1) knockout mice to improve a compensatory hyperinsulinemia, which was induced by hyperplasia in the beta cells or Langerhans' islands, as the diabetic model... -
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- Loss of Caveolin 1 is Associated With the Expression of Aquaporin 1 and Bladder Dysfunction in Mice
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Jung S, Kim SO, Cho KA, Song SH, Kang TW, Park K, Kwon D
- KMID: 2380824
- Int Neurourol J.
- 2015 Mar;19(1):34-38.
- doi: 10.5213/inj.2015.19.1.34
PURPOSE: It is suggested that caveolin and aquaporin might be closely associated with bladder signal activity. We investigated the effect of the deletion of caveolin 1, using caveolin 1 knockout... -
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- Difference in Resistance to Streptococcus pneumoniae Infection in Mice
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Jeong DG, Jeong ES, Seo JH, Heo SH, Choi YK
- KMID: 2053657
- Lab Anim Res.
- 2011 Jun;27(2):91-98.
- doi: 10.5625/lar.2011.27.2.91
Streptococcus pneumoniae is a major pathogen that causes various diseases, including pneumonia and sepsis, as millions of people suffer from S. pneumoniae infection worldwide. To better understand the immune and... -
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- Apoptosis Progression in the Hair Cells in the Organ of Corti of GJB2 Conditional Knockout Mice
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Zhang Y, Zhang X, Li L, Sun Y, Sun J
- KMID: 2134595
- Clin Exp Otorhinolaryngol.
- 2012 Sep;5(3):132-138.
- doi: 10.3342/ceo.2012.5.3.132
OBJECTIVES: Apoptosis may play an important role in the mechanism underlying the GJB2 gene conditional knockout (cCx26) mice cochlear cell death. The objective of this study was to explore the... -
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- Generation of knockout mouse models of cyclin-dependent kinase inhibitors by engineered nuclease-mediated genome editing
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Park BM, Roh JI, Lee J, Lee HW
- KMID: 2459304
- Lab Anim Res.
- 2018 Dec;34(4):264-269.
- doi: 10.5625/lar.2018.34.4.264
Cell cycle dysfunction can cause severe diseases, including neurodegenerative disease and cancer. Mutations in cyclin-dependent kinase inhibitors controlling the G1 phase of the cell cycle are prevalent in various cancers.... -
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- Effect of the absence of heat shock protein 70.1 (hsp70.1) on retinal photoreceptors in normal and rd mice
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Yu YS, Heo JH, Hwang SW, Kim JH, Seo JS, Khwarg SI, Chung H
- KMID: 754299
- Korean J Ophthalmol.
- 2001 Dec;15(2):67-73.
- doi: 10.3341/kjo.2001.15.2.67
The purposes of this study are to elucidate the retinal changes of heat shock protein 70.1 (hsp70.1) knockout mice and to compare them between in normal and in retinal degeneration... -
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- Effect of the Absence of Heat Shock Protein 70.1 (hsp70.1) on Retinal Photic Injury
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Kim JH, Yu YS, Chung H, Heo JW, Seo JS
- KMID: 754336
- Korean J Ophthalmol.
- 2003 Jun;17(1):7-13.
- doi: 10.3341/kjo.2003.17.1.7
This study aimed to evaluate the protective effect of heat shock protein70 (hsp70) on retinal photic injuries, and to determine the relationship between hsp70s from hsp70.1 and 70.3. C57BL/6 wild... -
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- Conditional knockout of brca1/2 and p53 in mouse ovarian surface epithelium: Do they play a role in ovarian carcinogenesis?
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Kim KY, Park DW, Jeung EB, Choi KC
- KMID: 1072177
- J Vet Sci.
- 2010 Dec;11(4):291-297.
- doi: 10.4142/jvs.2010.11.4.291
Alterations of genes are known to be critical for the induction of tumorigenesis, but the mechanism of ovarian carcinogenesis is little understood and remains to be elucidated. In this study,... -
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- Gene Expression Analysis of Galpha13-/- Knockout Mouse Embryos Reveals Perturbations in Galpha13 Signaling Related to Angiogenesis and Hypoxia
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Park JH, Choi S
- KMID: 2053272
- Genomics Inform.
- 2011 Dec;9(4):161-172.
Angiogenesis is regulated by a large number of molecules and complex signaling mechanisms. The G protein Galpha13 is a part of this signaling mechanism as an endothelial cell movement regulator.... -
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- Alpha-Tocopherol Transfer Protein (alpha-TTP): Insights from Alpha-Tocopherol Transfer Protein Knockout Mice
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Lim Y, Traber MG
- KMID: 2313322
- Nutr Res Pract.
- 2007 Dec;1(4):247-253.
Alpha-tocopherol transfer protein (alpha-TTP) is a liver cytosolic transport protein that faciliates alpha-tocopherol (alpha-T) transfer into liver secreted plasma lipoproteins. Genetic defects in alpha-TTP, like dietary vitamin E deficiency, are... -
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- Effects of Chronic Mild Stress in Female Bax Inhibitor-1-Gene Knockout Mice
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Sui ZY, Chae HJ, Huang GB, Zhao T, Shrestha Muna S, Chung YC
- KMID: 1432537
- Clin Psychopharmacol Neurosci.
- 2012 Dec;10(3):155-162.
- doi: 10.9758/cpn.2012.10.3.155
OBJECTIVE: The anti-apoptotic protein Bax inhibitor-1 (BI-1) is a regulator of apoptosis linked to endoplasmic reticulum (ER) stress, and BI-1-/- mice exhibit increased sensitivity to tissue damage. The purpose of... -
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- Alpha-Calcitonin Gene-Related Peptide-Null Mice Shows Normal Responses to Various Noxious Stimuli
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Lee J, Emeson RB
- KMID: 1587473
- Korean J Physiol Pharmacol.
- 2006 Dec;10(6):323-327.
Despite the wealth of data concerning the roles of alpha-CGRP in nociceptive behaviors, alpha-CGRP-null mice showed no obvious phenotypic differences in nociceptive behaviors from wild type. The present studies specifically... -
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- IL-4-deficient Mice Aggravate Hypersensitivity Pneumonitis
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Hwang SJ, Chung DH
- KMID: 2163198
- Immune Netw.
- 2008 Sep;8(3):90-97.
- doi: 10.4110/in.2008.8.3.90
BACKGROUND: Hypersensitivity pneumonitis (HP) comprises a group of lung diseases resulting from repeated inhalation of various antigens such as Saccharopolyspora rectivirgula (SR). HP is categorized as a Th1 disease. Therefore,... -
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- Roles of Periostin in Symptom Manifestation and Airway Remodeling in a Murine Model of Allergic Rhinitis
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Hur DG, Khalmuratova R, Ahn SK, Ha YS, Min YG
- KMID: 1970711
- Allergy Asthma Immunol Res.
- 2012 Jul;4(4):222-230.
- doi: 10.4168/aair.2012.4.4.222
PURPOSE: Periostin was originally identified as a secreted factor during screening of a mouse osteoblastic library. In a recent study, periostin was found to directly regulate eosinophil accumulation in allergic... -
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- Mouse Models of Gastric Carcinogenesis
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Yu S, Yang M, Nam KT
- KMID: 2372515
- J Gastric Cancer.
- 2014 Jun;14(2):67-86.
Gastric cancer is one of the most common cancers in the world. Animal models have been used to elucidate the details of the molecular mechanisms of various cancers. However, most... -
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- Regulation of exercise-stimulated glucose uptake in skeletal muscle
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Koh HJ
- KMID: 2328142
- Ann Pediatr Endocrinol Metab.
- 2016 Jun;21(2):61-65.
- doi: 10.6065/apem.2016.21.2.61
AMP-activated protein kinase (AMPK) is a Ser/Thr kinase that has been thought to be an important mediator for exercise-stimulated glucose uptake in skeletal muscle. Liver kinase B1 (LKB1) is an... -
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- Pathologic Characteristics of Ovarian Hemorrhagic Polycyst in Estrogen Receptor-alpha (ERalpha) Knockout Mice and Roles of ERalpha in Hemorrhagic Polycyst
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Son HJ, Kim JH, Lee HK, Park MJ, Kang DW, Ko CM
- KMID: 2277575
- Korean J Pathol.
- 2010 Aug;44(4):376-383.
BACKGROUND: Polycystic ovary syndrome (PCOS) is the most common endocrinopathy causing anovulation in women of childbearing age. It has been well established that estrogen receptor-alpha knockout (ERalphaKO) mice display several... -
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