Tuberc Respir Dis.  2011 Oct;71(4):254-258.

Lack of Association between the Klotho Gene and COPD

• Kim WJ
• Oh YM
• Kim TH
• Lee JH
• Kim EK
• Lee JH
• Lee SM
• Shin TR
• Yoon HI
• Lim SY
• Lee SD

Abstract

BACKGROUND
Although the aging process and features of chronic obstructive pulmonary disease (COPD) have several similarities, the relationship between aging and COPD pathogenesis remains incompletely understood. The klotho gene was found to be related to premature aging and emphysematous changes in an animal model. We investigated whether klotho gene polymorphisms are related to COPD susceptibility and emphysema severity.
METHODS
A total of 219 COPD subjects from the Korean Obstructive Lung Disease Cohort and 305 control subjects were genotyped for two single nucleotide polymorphisms (SNPs) of the klotho gene associated with coronary artery disease. Logistic regression was performed to determine the association of these SNPs with COPD susceptibility and linear regression was performed to investigate their association with emphysema severity in COPD subjects.
RESULTS
The mean age of the COPD subjects was 66 years and their mean FEV1 was 1.46 L. There were no associations between either SNP or COPD susceptibility (p=0.6 and 0.2, respectively) and there were no associations with emphysema severity.
CONCLUSION
Genetic polymorphisms of the klotho gene were not associated with COPD in a Korean population.

Keyword

Pulmonary Disease, Chronic Obstructive; Polymorphism, Genetic

MeSH Terms

Aging
Aging, Premature
Cohort Studies
Coronary Artery Disease
Emphysema
Linear Models
Logistic Models
Lung Diseases, Obstructive
Models, Animal
Polymorphism, Genetic
Polymorphism, Single Nucleotide
Pulmonary Disease, Chronic Obstructive

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