Korean J Biol Psychiatry.
2015 May;22(2):40-46. 10.0000/kjbp.2015.22.2.40.
Neuroglial Cell and Alzheimer's Disease
- Affiliations
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- 1Department of Psychiatry, School of Medicine, Chungnam National University, Daejeon, Korea. kimjl@cnu.ac.kr
- KMID: 2299826
- DOI: http://doi.org/10.0000/kjbp.2015.22.2.40
Abstract
- Neuroglial cells are fundamental for brain homeostasis and defense to intrinsic or extrinsic changes. Loss of their function and overreactivity to stimuli contribute to the aging of brain. Alzheimer's disease (AD) could be caused by more dramatic response in neuroglia associated with various chemokines and cytokines. Neuroglia of the AD brain shares some phenotypes with aging neuroglia. In addition, neuroglial activation and neuroinflammation are commonly showed in neurodegeneration. Thus neuroglia would be a promising target for therapeutics of AD.
