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Amyloid-Targeting Drugs for the Treatment of Alzheimer Disease

Lee AY

Alzheimer’s disease (AD) is the most common cause of dementia, characterized by cognitive impairment, neurobehavioral changes, and loss of functional ability. Current therapeutic options for AD are limited to medications...
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Effects of the fermented Zizyphus jujuba in the amyloid β25-35 -induced Alzheimer's disease mouse model

Kim MJ, Jung JE, Lee S, Cho EJ, Kim HY

BACKGROUD/OBJECTIVES: Alzheimer's disease (AD) is the most common cause of dementia in the elderly. Due to the increased incidence of dementia, there is a corresponding increase concerning the importance of...
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Glia-Like Cells from Human Mesenchymal Stem Cells Protect Neural Stem Cells in an In Vitro Model of Alzheimer's Disease by Reducing NLRP-3 Inflammasome

Hwang M, Song Sh, Chang MS, Koh SH

Background and Purpose: Neural stem cells (NSCs) have the ability to regenerate, proliferate, and differentiate, enabling them to play important roles in the recovery of the damaged nervous system. However,...
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Protective Effect of Rice Bran Oil against β-Amyloid Protein-Induced Memory Impairment and Neuronal Death in Mice

Jang JY, Lee HK, Yoo HS, Seong YH

This study was undertaken to investigate the protective effect of rice bran oil (RBO) on amyloid β protein (Aβ) (25-35)-induced memory impairment and brain damage in an ICR mouse model....
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Effect of Integrated Cognitive Intervention Therapy in Patients with Mild to Moderate Alzheimer's Disease

Jung YH, Lee S, Kim WJ, Lee JH, Kim MJ, Han HJ

Background and Purpose: The effect of the integrated program comprising cognitive training, art therapy, and music therapy has not been extensively studied in patients with Alzheimer's disease (AD). The present...
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A Validation Study of the Inbrain CST: a Tablet Computer-based Cognitive Screening Test for Elderly People with Cognitive Impairment

Chin J, Kim DE, Lee H, Yun J, Lee BH, Park J, Yeom J, Shin DS, Na DL

Background: Computerized versions of cognitive screening test could have advantages over pencil-and-paper versions by eliminating rater-dependent factors and saving the time required to score the tests and report the results....
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Does Episodic Memory Training Improve Episodic Memory of Older Adults with Alzheimer's Disease?

Park JH, Lee SA

To date, it is unclear whether cognitive intervention on episodic memory (EM) is effective in improving all or a subset of EM components in Alzheimer's disease (AD). Therefore, this study...
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Efficacies of Cognitive Interventions in the Elderly with Subjective Cognitive Decline: A Prospective, Three-Arm, Controlled Trial

Hong YJ, Lee JH, Choi EJ, Han N, Kim JE, Park SH, Kim HJ, Kang DW

Background and Purpose A cognitive intervention (CI) is thought to improve cognition and delay cognitive decline via neuronal plasticity and cognitive resilience. Subjective cognitive decline (SCD) might be the first symptomatic...
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Alzheimer's Disease Diagnosis Using Misfolding Proteins in Blood

Lee H, Ugay D, Hong S, Kim Y

Alzheimer's disease (AD) is pathologically characterized by a long progressive phase of neuronal changes, including accumulation of extracellular amyloid-β (Aβ) and intracellular neurofibrillary tangles, before the onset of observable symptoms....
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A Comprehensive Visual Rating Scale for Predicting Progression from Mild Cognitive Impairment to Dementia in Patients with Alzheimer's Pathology or Suspected Non-Alzheimer's Pathology

Park SW, Kim S, Park J, Jang JW, Kim S

Background and Purpose: To identify biomarkers for prediction of the progression to dementia in mild cognitive impairment (MCI) patients, evaluation of brain structure changes has been validated by a comprehensive...
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Clinical Usefulness of ¹⁸F-FC119S Positron-Emission Tomography as an Auxiliary Diagnostic Method for Dementia: An Open-Label, Single-Dose, Evaluator-Blind Clinical Trial

Lee I, Na HR, Byun BH, Lim I, Kim BI, Choi CW, Ko IO, Lee KC, Kim KM, Park SY, Kim YK, Lee JY, Bu SH, Kim JH, Kil HS, Park C, Chi DY, Ha JH, Lim SM

BACKGROUND AND PURPOSE: The aim of this study was to determine the diagnostic performance and safety of a new ¹⁸F-labeled amyloid tracer, ¹⁸F-FC119S. METHODS: This study prospectively recruited 105 participants, comprising...
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The Cortical Neuroanatomy Related to Specific Neuropsychological Deficits in Alzheimer's Continuum

Kang SH, Park YH, Lee D, Kim JP, Chin J, Ahn Y, Park SB, Kim HJ, Jang H, Jung YH, Kim J, Lee J, Kim JS, Cheon BK, Hahn A, Lee H, Na DL, Kim YJ, Seo SW

BACKGROUND AND PURPOSE: In Alzheimer's continuum (a comprehensive of preclinical Alzheimer's disease [AD], mild cognitive impairment [MCI] due to AD, and AD dementia), cognitive dysfunctions are often related to cortical...
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Diabetes-related Amylin Dyshomeostasis: a Contributing Factor to Cerebrovascular Pathology and Dementia

Ly H, Despa F

Type 2 diabetes (T2D) increases the risk for cerebrovascular disease (CVD) and dementia. The underlying molecular mechanisms remain elusive, which hampers the development of treatment or/and effective prevention strategies. Recent...
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Photobiomodulation as a treatment for neurodegenerative disorders: current and future trends

Hong N

Photobiomodulation (PBM) is a rapidly growing as an innovative therapeutic modality for various types of diseases in recent years. Neuronal degeneration is irreversible process and it is proven to be...
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Targeted Downregulation of kdm4a Ameliorates Tau-engendered Defects in Drosophila melanogaster

Park SY, Seo J, Chun YS

BACKGROUND: Tauopathies, a class of neurodegenerative diseases that includes Alzheimer's disease (AD), are characterized by the deposition of neurofibrillary tangles composed of hyperphosphorylated tau protein in the human brain. As...
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Cerebrospinal Fluid Levels of β-Amyloid 40 and β-Amyloid 42 are Proportionately Decreased in Amyloid Positron-Emission Tomography Negative Idiopathic Normal-Pressure Hydrocephalus Patients

Kim HJ, Lim TS, Lee SM, Kim TS, Kim Y, An YS, Youn YC, Park SA, Chang J, Moon SY

BACKGROUND AND PURPOSE: Cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) could be misleading in idiopathic normal-pressure hydrocephalus (iNPH). We therefore investigated the CSF biomarkers in 18F-florbetaben amyloid-negative positron-emission tomography...
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Long Noncoding RNA NEAT1 Aggravates Aβ-Induced Neuronal Damage by Targeting miR-107 in Alzheimer's Disease

Ke S, Yang Z, Yang F, Wang X, Tan J, Liao B

PURPOSE: Alzheimer's disease (AD) is the most common neurodegenerative disease, with a rising prevalence worldwide. Long noncoding RNAs (lncRNAs) have been found to play important roles in the development and...
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Association between Thyroid-Related Hormones and Cognitive Function in Patients with Alzheimer's Disease and Mild Cognitive Impairment

Park DY, Kim H, Lee KJ

OBJECTIVES: The association between thyroid-related hormones and cognitive function has been controversial. The purpose of this study is to compare the levels of thyroid-related hormones in patients with Alzheimer's disease...
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Chemical Constituents from Solenostemma argel and their Cholinesterase Inhibitory Activity

Demmak RG, Bordage S, Bensegueni A, Boutaghane N, Hennebelle T, Mokrani EH, Sahpaz S

Alzheimer's disease is a chronic neurodegenerative disorder with no curative treatment. The commercially available drugs, which target acetylcholinesterase, are not satisfactory. The aim of this study was to investigate the...
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Memantine Improves Cognitive Function and Alters Hippocampal and Cortical Proteome in Triple Transgenic Mouse Model of Alzheimer's Disease

Zhou X, Wang L, Xiao W, Su Z, Zheng C, Zhang Z, Wang Y, Xu B, Yang X, Hoi MP

Memantine is a non-competitive N-methyl-D-aspartate receptor (NMDAR) antagonist clinically approved for moderate-to-severe Alzheimer's disease (AD) to improve cognitive functions. There is no report about the proteomic alterations induced by memantine...
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