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Nusinersen as a Therapeutic Agent for Spinal Muscular Atrophy

Li Q

The reduction of survival motor neuron (SMN) protein causes spinal muscular atrophy (SMA), an autosomal recessive neuromuscular disease. Nusinersen is an antisense oligonucleotide, approved by the FDA, which specifically binds...
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Reflex and Spontaneous Movements in Adult Patients during the Process of Determining Brain Death in Korea

Kim DH, Kwon OY, Yang TW, Kim M, Lee J, Cho W, Yeom JS, Kim YS

BACKGROUND: Brain death is a clinical diagnosis that implies irreversible loss of function of the entire brain, including the brainstem and both hemispheres. Based on previous reports, it is not...
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Acute Leukemia Relapse Presenting as Recurrent Involvement of the Optic Nerve

Lee SY, Yoon JH, Chung SA

PURPOSE: To report two cases with recurrent involvement of the optic nerve as the initial sign of acute leukemic relapse. CASE SUMMARY: An 8-year-old male with acute lymphoblastic leukemia on the...
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Changes in attention variables in those who treated with anticholinergic agents for nonmonosymptomatic enuresis

Jang G, Im YJ, Suh J, Park K

PURPOSE: Brain dysfunction related to areas regarding attention and arousal may occur not only in patients with attention-deficit/hyperactivity disorder (ADHD) but also in patients with enuresis and daytime symptoms. This...
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Changes in plasma lipoxin A4, resolvins and CD59 levels after ischemic and traumatic brain injuries in rats

Jung JS, Kho AR, Lee SH, Choi BY, Kang SH, Koh JY, Suh SW, Song DK

Ischemic and traumatic brain injuries are the major acute central nervous system disorders that need to be adequately diagnosed and treated. To find biomarkers for these acute brain injuries, plasma...
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Feasibility of Robot-Assisted Gait Training with an End-Effector Type Device for Various Neurologic Disorders

Choi S, Kim SW, Jeon HR, Lee JS, Kim DY, Lee JW

Robots are being used to assist the recovery of walking ability for patients with neurologic disorders. This study aimed to evaluate the feasibility and functional improvement of training with robot-assisted...
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Ultrasonographic Demonstration of the Tissue Microvasculature in Children: Microvascular Ultrasonography Versus Conventional Color Doppler Ultrasonography

Yoo J, Je BK, Choo JY

Microvascular ultrasonographic imaging is the most recent and unique Doppler ultrasound technique. It uses an advanced clutter filter that can remove clutter artifacts and preserve the low-velocity microvascular flow signal....
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Clinical Application of Meditation in Children and Adolescents

Kwack YS, Moon DS

Meditation is one of the psychological therapeutic techniques that can be applied to many conditions, including stress reduction. Meditation can be an alternative to overcoming the limitations of existing therapies,...
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Opioids and Antidepressants for Pain Control in Musculoskeletal Disease

Park SJ, Kim WS, Jang T

The progression of aging and the increase in musculoskeletal diseases have led to an increase in invasive treatment methods, including various surgical methods, but conservative treatment should be attempted before...
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Evolution of tobacco products

Lee S, Kim J

Tobacco products are rapidly evolving. Since the World Health Organization Framework Convention on Tobacco Control came to effect in 2005, the parties of the treaty have been aiming to control...
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Serial Magnetic Resonance Imaging Findings in Hyperglycemia-Related Osmotic Demyelination Syndrome: A Case Report

Kim JH, Park NH, Park JY, Kim SJ

We report a rare case of hyperglycemia-related osmotic demyelination syndrome (ODS) with focus on the imaging findings. A 61-year-old man with diabetes was admitted for general weakness and severe thirst....
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Sevoflurane with opioid or dexmedetomidine infusions in dogs undergoing intracranial surgery: a retrospective observational study

Marquez-Grados F, Vettorato , Corletto F

This study reports the clinical use of two sevoflurane-based anesthetic techniques in dogs undergoing craniectomy. Twenty-one animals undergoing elective rostrotentorial or transfrontal craniectomy for brain tumor excision, anesthetized with sevoflurane,...
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Fluoxetine Induces Apoptotic and Oxidative Neuronal Death Associated with The Influx of Copper Ions in Cultured Neuronal Cells

Hwang S, Kim JK

We examined the effect of fluoxetine, a selective serotonin reuptake inhibitor antidepressant, on neuronal viability in mouse cortical near-pure neuronal cultures. Addition of fluoxetine to the media for 24 hours...
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“Self-Neuroenhancement”: The Last Frontier of Noninvasive Brain Stimulation?

Fisicaro F, Lanza G, Bella R, Pennisi M

No abstract available.
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Clinical Usefulness of ¹⁸F-FC119S Positron-Emission Tomography as an Auxiliary Diagnostic Method for Dementia: An Open-Label, Single-Dose, Evaluator-Blind Clinical Trial

Lee I, Na HR, Byun BH, Lim I, Kim BI, Choi CW, Ko IO, Lee KC, Kim KM, Park SY, Kim YK, Lee JY, Bu SH, Kim JH, Kil HS, Park C, Chi DY, Ha JH, Lim SM

BACKGROUND AND PURPOSE: The aim of this study was to determine the diagnostic performance and safety of a new ¹⁸F-labeled amyloid tracer, ¹⁸F-FC119S. METHODS: This study prospectively recruited 105 participants, comprising...
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Individual-Level Lesion-Network Mapping to Visualize the Effects of a Stroke Lesion on the Brain Network: Connectograms in Stroke Syndromes

Lim JS, Lee JJ, Woo CW, Song J, Oh MS, Yu KH, Lee BC

BACKGROUND AND PURPOSE: Similar-sized stroke lesions at similar locations can have different prognoses in clinical practice. Lesion-network mapping elucidates network-level effects of lesions that cause specific neurologic symptoms and signs,...
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Coexistence of Cerebral Microbleeds and Amyloid Pathology in Patients with Cognitive Complaints

Lim EY, Ryu SY, Shim YS, Yang DW, Cho AH

BACKGROUND AND PURPOSE: We investigated the prevalence of amyloid positivity and cerebral microbleeds (CMBs) in subjects with cognitive complaints with the aim of identifying differences in clinical parameters and cognitive...
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A Cortical Substrate for Square-Wave Jerks in Progressive Supranuclear Palsy

Anagnostou E, Karavasilis E, Potiri I, Constantinides V, Efstathopoulos E, Kapaki E, Potagas C

BACKGROUND AND PURPOSE: Square-wave jerks (SWJs) are the most common saccadic intrusion in progressive supranuclear palsy (PSP), but their genesis is uncertain. We aimed to determine the characteristics of SWJs...
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Plasma Fibroblast Growth Factor 23 Concentration Is Associated with Intracranial Cerebral Atherosclerosis in Acute Ischemic Stroke Patients

Chang Y, Kim J, Woo HG, Ryu DR, Oh HJ, Song TJ

BACKGROUND AND PURPOSE: Fibroblast growth factor 23 (FGF23) is associated with atherosclerosis via nitric-oxide-associated endothelial dysfunction and calcium-phosphate-related bone mineralization. This study aimed to determine the association of the plasma...
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Decreased inward rectifier and voltage-gated K⁺ currents of the right septal coronary artery smooth muscle cells in pulmonary arterial hypertensive rats

Kim SE, Yin MZ, Kim HJ, Vorn R, Yoo HY, Kim SJ

In vascular smooth muscle, K⁺ channels, such as voltage-gated K⁺ channels (Kv), inward-rectifier K⁺ channels (Kir), and big-conductance Ca²⁺-activated K⁺ channels (BK(Ca)), establish a hyperpolarized membrane potential and counterbalance the...
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