Allergy Asthma Immunol Res.  2016 Sep;8(5):461-465. 10.4168/aair.2016.8.5.461.

Soluble CD93 as a Novel Biomarker in Asthma Exacerbation

Affiliations
  • 1Internal Medicine Department, Medical Faculty, Kurdistan University of Medical Sciences, Sanandaj, Iran. naseh.sigari@muk.ac.ir
  • 2Kurdistan Cellular & Molecular Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran.
  • 3Internal Medicine Department, Kurdistan University of Medical Sciences, Sanandaj, Iran.
  • 4Department of Epidemiology and Biostatistics, School of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.
  • 5Pediatrics Department, Medical Faculty,Kurdistan University of Medical Sciences, Sanandaj, Iran.

Abstract

Asthma research is shifting from studying symptoms and lung functions to the narrow-focus cellular profiles protein analysis, biomarkers, and genetic markers. The transmembrane glycoprotein CD93 is involved in endothelial cell migration, angiogenesis, leukocytes extravasation, apoptosis, innate immunity and inflammation. Relationships between the serum level of soluble CD93 (sCD93) and acute myocardial infarction/premature MI/inflammatory arthritis/skin sclerosis have recently been reported. We hypothesized that sCD93 would be elevated during the acute phase of asthma. We measured the serum level of sCD93 in 57 patients with asthma exacerbation and 57 age-and gender-matched healthy controls. Additionally, sCD93 was reassessed at the time of discharge from the hospital. Clinical characteristics and peak expiratory flow (PEF) of the patients were assessed. The primary outcome was the comparison of serum level of sCD93 between asthmatics and healthy subjects. The sCD93 values ranged from 128 to 789 ng/mL in asthmatics (345.83±115.81) and from 31 to 289 ng/mL in control subjects (169.46±62.43). The difference between the 2 groups was statistically significant (P<0.001). The association between sCD93 and asthma remained significant after adjusting for age, sex, and BMI. The differences between asthmatics and controls remained significant on the last day of hospital stay. The association between sCD93 and PEF was not significant. In conclusion, the serum level of soluble CD93 is increased in patients with asthma exacerbation. It also showed that serum levels of sCD93 decreased with treatment of asthma attack. The clinical usefulness of determination of sCD93 as a biomarker of asthma requires further studies.

Keyword

Asthma; biomarker; CD93

MeSH Terms

Apoptosis
Asthma*
Biomarkers
Endothelial Cells
Genetic Markers
Glycoproteins
Healthy Volunteers
Humans
Immunity, Innate
Inflammation
Length of Stay
Leukocytes
Lung
Sclerosis
Biomarkers
Genetic Markers
Glycoproteins

Figure

  • Fig. 1 Comparison of serum levels of CD93 between healthy control subjects and asthmatic patients. The mean serum level of CD93 in control group was 169.45 (± 62.43) and in the first and last day of hospital stay of asthmatics were 345.83 (±115.81) and 303.54 (±110.75) respectively. The differences between control subjects and both groups of asthmatics were significant.(P=0.001, P=0.001). The difference between first and last day of hospital stay in asthmatics remain significant (P=0.004).

  • Fig. 2 The association between PEF at the first day of hospital stay and CD93 was negative (A). This association in the last day of hospital staying remained negative (B).


Cited by  1 articles

Soluble CD93 in Serum as a Marker of Allergic Inflammation
Hye Jung Park, Heejae Han, Sang Chul Lee, Young Woong Son, Da Woon Sim, Kyung Hee Park, Yoon Hee Park, Kyoung Yong Jeong, Jung-Won Park, Jae-Hyun Lee
Yonsei Med J. 2017;58(3):598-603.    doi: 10.3349/ymj.2017.58.3.598.


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