Korean J Intern Med.  2017 Mar;32(2):295-301. 10.3904/kjim.2014.242.

Clinical significance of serum vascular endothelial growth factor in young male asthma patients

Affiliations
  • 1Division of Allergy and Pulmonary Medicine, Department of Internal Medicine, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea. chinkook@catholic.ac.kr
  • 2Division of Respiratory Medicine, Department of Internal Medicine, Korea University Guro Hospital, Seoul, Korea.
  • 3Department of Internal Medicine, Gachon University Gil Medical Center, Incheon, Korea.
  • 4Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, The Armed Forces Capital Hospital, Seongnam, Korea.

Abstract

BACKGROUND/AIMS
Vascular endothelial growth factor (VEGF) is an important mediator of angiogenesis. However, little is known about the potential use of serum levels of VEGF as a biomarker for asthma. We investigated the differences in VEGF levels among normal controls, stable asthma patients, and those with exacerbation of acute asthma. All subjects were young males.
METHODS
We measured VEGF levels in each patient group, and examined any serial changes in those with acute exacerbation.
RESULTS
VEGF levels were significantly higher in stable asthmatic patients and even more so in acute asthmatic patients, compared to healthy controls. However, there was no correlation between VEGF levels and forced expiratory volume in 1 second in patients with stable asthma. In addition, there were no correlations between VEGF levels and asthma control test scores. In patients with acute exacerbation, VEGF levels significantly increased during the acute period; their levels decreased gradually at 7 and 14 days after treatment.
CONCLUSIONS
Compared to normal control patients, the serum levels of VEGF were elevated in stable asthma patients and even more elevated in patients with acute exacerbation. However, the role of VEGF as a biomarker in stable asthma is limited. In patients with acute exacerbation, VEGF levels were associated with clinical improvements.

Keyword

Asthma; Serum; Vascular endothelial growth factor A; Lung function
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