Korean J Obstet Gynecol.  2005 Jan;48(1):119-125.

Analysis of C(-634)G polymorphism in the promotor region of the vascular endothelial growth factor gene in Korean women with endometriosis

• Lee HA
• Jeon GH
• Choi JW
• Kim SH
• Chae HD
• Kim CH
• Kang BM
• Choi YM

Abstract

OBJECTIVE
This study was designed to investigate the association between C(-634)G polymorphism in the promotor region of vascualr endothelial growth factor (VEGF) and endometriosis.
METHODS
The genomic DNA was extracted from 100 patients with surgically confirmed endometriosis and 100 control group from July 2003 to June 2004. Following extraction of genomic DNA, genotyping of C(-634)G polymorphism of VEGF gene was performed by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP).
RESULTS
There was no significant difference in the frequency of CC genotype between the patients with endometriosis (21%) and the control group (19%). No significant difference in the frequency of allele of -634C was noted between the two groups (43.5% vs 44%), either.
CONCLUSION
The C(-634)G polymorphism in the promotor region of VEGF gene is not associated with susceptibility to endometriosis in Korean women.

Keyword

Endometriosis; Polymorphism; VEGF gene

MeSH Terms

Alleles
DNA
Endometriosis*
Endothelial Growth Factors
Female
Genotype
Humans
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length
Promoter Regions, Genetic*
Vascular Endothelial Growth Factor A*
DNA
Endothelial Growth Factors
Vascular Endothelial Growth Factor A