J Genet Med.  2009 Dec;6(2):121-130.

Genetic Polymorphisms in Patients with Endometriosis in the Korean Population

Affiliations
  • 1Department of Obstetrics and Gynecology, Seoul Medical Center, Seoul, Korea.
  • 2Department of Obstetrics and Gynecology, Medical Research Center, Seoul National University College of Medicine, Seoul, Korea. ymchoi@snu.ac.kr
  • 3Institute of Reproductive Medicine and Population, Medical Research Center, Seoul National University College of Medicine, Seoul, Korea.

Abstract

To analyze a wide variety of polymorphisms in patients with endometriosis is important since this disease has a strong genetic component. Until now, more than 30 Korean studies have been performed in order to elucidate the possible role of specific polymorphisms in the susceptibility to endometriosis. The most meaningful polymorphisms in Korean patients with endometriosis came from studies investigating GSTM1, AhRR, ER-alpha, VEGF, AHSG, and TNF-alpha. However, following studies should be made to confirm the consistency of the data to have some implications in the prediction of endometriosis. In this review, we also present the future direction of the association studies in complex trait disease such as endometriosis.

Keyword

Endometriosis; Genetic polymorphism
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