- Carrier Frequency of Spinal Muscular Atrophy in a Large-scale Korean Population
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Park JE, Yun SA, Roh EY, Yoon JH, Shin S, Ki CS
- KMID: 2470330
- Ann Lab Med.
- 2020 Jul;40(4):326-330.
- doi: 10.3343/alm.2020.40.4.326
Spinal muscular atrophy (SMA) is an autosomal recessive disease characterized by progressive proximal muscle weakness and atrophy. Given the recent introduction of gene therapies, knowledge of the SMA carrier frequency... -
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- Enzymes involved in folate metabolism and its implication for cancer treatment
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Kim SE
- KMID: 2471876
- Nutr Res Pract.
- 2020 Apr;14(2):95-101.
- doi: 10.4162/nrp.2020.14.2.95
BACKGROUND/OBJECTIVES: Folate plays a critical role in DNA synthesis and methylation. Intracellular folate homeostasis is maintained by the enzymes folylpolyglutamate synthase (FPGS) and γ-glutamyl hydrolase (GGH). FPGS adds glutamate residues... -
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- Happle-Tinschert Syndrome: A Case Report of Unilateral Segmentally Arranged Basaloid Follicular Hamartoma with Scoliosis and Review of Literature
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Seo SH, Lee SE, Kim SC
- KMID: 2471344
- Ann Dermatol.
- 2020 Apr;32(2):159-163.
- doi: 10.5021/ad.2020.32.2.159
Happle-Tinschert syndrome is a rare disease characterized by unilateral, segmentally arranged basaloid follicular hamartoma (BFH) with osseous, dental, and cerebral anomalies. Although BFH has been demonstrated to be associated with... -
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- Epigenetic Regulation of Filaggrin Gene Expression in Human Epidermal Keratinocytes
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Lee J, Jang A, Seo SJ, Myung SC
- KMID: 2471338
- Ann Dermatol.
- 2020 Apr;32(2):122-129.
- doi: 10.5021/ad.2020.32.2.122
BACKGROUND: Loss-of-function mutations in the filaggrin gene (FLG), which encodes an epidermal protein crucial for the formation of a functional skin barrier, have been identified as a major predisposing factor... -
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- Characteristics of DNMT3A mutations in acute myeloid leukemia
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Park DJ, Kwon A, Cho BS, Kim HJ, Hwang KA, Kim M, Kim Y
- KMID: 2472004
- Blood Res.
- 2020 Mar;55(1):17-26.
- doi: 10.5045/br.2020.55.1.17
BACKGROUND: DNMT3A mutations occur in approximately 20% of AML cases and are associated with changes in DNA methylation. CDKN2B plays an important role in the regulation of hematopoietic progenitor cells... -
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- The Influence of Bcl-3 Expression on Cell Migration and Chemosensitivity of Gastric Cancer Cells via Regulating Hypoxia-Induced Protective Autophagy
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Hu L, Bai Z, Ma X, Bai N, Zhang Z
- KMID: 2471929
- J Gastric Cancer.
- 2020 Mar;20(1):95-105.
- doi: 10.5230/jgc.2020.20.e9
PURPOSE: Gastric cancer is a highly metastatic malignant tumor, often characterized by chemoresistance and high mortality. In the present study, we aimed to investigate the role of B-cell lymphoma 3... -
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- Genetic Characterization of Molecular Targets in Korean Patients with Gastrointestinal Stromal Tumors
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Park J, Yoo HM, Sul HJ, Shin S, Lee SW, Kim JG
- KMID: 2471923
- J Gastric Cancer.
- 2020 Mar;20(1):29-40.
- doi: 10.5230/jgc.2020.20.e2
PURPOSE: Gastrointestinal stromal tumors (GISTs) frequently harbor activating gene mutations in either KIT or platelet-derived growth factor receptor A (PDGFRA) and are highly responsive to several selective tyrosine kinase inhibitors.... -
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- Frequency of Mycobacterium tuberculosis Among M. tuberculosis Complex Strains Isolated from Clinical Specimen
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Cho H, Kim JB, Uh Y
- KMID: 2471856
- Ann Clin Microbiol.
- 2020 Mar;23(1):21-31.
- doi: 10.5145/ACM.2020.23.1.21
BACKGROUND: Rapid and accurate detection of Mycobacterium tuberculosis (MTB) is of primary importance for infection control and selection of anti-tuberculosis drugs. However, most clinical laboratories report MTB complex (MTC) without... -
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- High-risk human papillomavirus testing as a primary screening for cervical cancer: position statement by the Korean Society of Obstetrics and Gynecology and the Korean Society of Gynecologic Oncology
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Kong TW, Kim M, Kim YH, Kim YB, Kim J, Kim JW, Park MH, Park JH, Rhee JH, Lim MC, Hong JS, on behalf of Korean Society of Obstetrics and Gynecology developed by Position Statement Writing Committee
- KMID: 2471746
- Obstet Gynecol Sci.
- 2020 Mar;63(2):107-107.
- doi: 10.5468/ogs.2020.63.2.107
Based on emerging data and current knowledge regarding high-risk human papillomavirus (hrHPV) testing as a primary screening for cervical cancer, the Korean Society of Obstetrics and Gynecology and the Korean... -
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- Human papillomavirus (HPV) DNA detection in uterine cervix cancer after radiation indicating recurrence: a systematic review and meta-analysis
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Sabeena S, Kuriakose , Damodaran , Ravishankar N, Arunkumar
- KMID: 2470871
- J Gynecol Oncol.
- 2020 Mar;31(2):e20.
- doi: 10.3802/jgo.2020.31.e20
OBJECTIVE: The causal association of human papillomavirus (HPV) in uterine cervical cancer was well established and this oncogenic virus was reported to be a biomarker for overall recurrence and central... -
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- Evaluation of the QuantaMatrix Multiplexed Assay Platform for Molecular Diagnosis of Multidrug- and Extensively Drug-Resistant Tuberculosis Using Clinical Strains Isolated in Myanmar
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Chang Y, Kim S, Kim Y, Ei PW, Hwang D, Lee J, Chang CL, Lee H
- KMID: 2460911
- Ann Lab Med.
- 2020 Mar;40(2):142-147.
- doi: 10.3343/alm.2020.40.2.142
BACKGROUND: Although the incidence of tuberculosis (TB) is decreasing, cases of multidrug-resistant (MDR) TB and extensively drug-resistant (XDR) TB continue to increase. As conventional phenotype drug susceptibility testing (pDST) takes... -
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- Matrix Metallopeptidase 3 Polymorphisms: Emerging genetic Markers in Human Breast Cancer Metastasis
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Suhaimi SA, Chan SC, Rosli R
- KMID: 2470877
- J Breast Cancer.
- 2020 Feb;23(1):1-9.
- doi: 10.4048/jbc.2020.23.e17
Matrix metallopeptidase 3 or MMP3, is a zinc-dependent proteolytic enzyme that is involved in various physiological processes via modification of the extracellular matrix. In particular, its over-expression has been associated... -
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- Hepatitis B Prophylaxis after Liver Transplantation in Korea: Analysis of the KOTRY Database
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Park GC, Hwang S, Kim MS, Jung DH, Song GW, Lee KW, Kim JM, Lee JG, Ryu JH, Choi DL, Wang HJ, Kim BW, Kim DS, Nah YW, You YK, Kang KJ, Yu HC, Park YH, Lee KJ, Kim YK
- KMID: 2469941
- J Korean Med Sci.
- 2020 Feb;35(6):e36.
- doi: 10.3346/jkms.2020.35.e36
BACKGROUND: Prophylaxis for hepatitis B virus (HBV) recurrence is essential after liver transplantation (LT) in HBV-associated recipients. We conducted real-world analysis of HBV prophylaxis after LT in the Korean population. METHODS:... -
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- NOTCH1 Pathway is Involved in Polyhexamethylene Guanidine-Induced Humidifier Disinfectant Lung Injuries
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Lee E, Kang MJ, Kim JH, Lee SH, Lee SY, Cho HJ, Yoon J, Jung S, Park Y, Oh DK, Hong SB, Hong SJ
- KMID: 2468494
- Yonsei Med J.
- 2020 Feb;61(2):186-191.
- doi: 10.3349/ymj.2020.61.2.186
An outbreak of fatal humidifier disinfectant lung injuries (HDLI) occurred in Korea. Human studies on mechanisms underlying HDLI have yet to be conducted. This study aimed to investigate methylation changes... -
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- Minocycline and Its Impact on Microbial Dysbiosis in the Skin and Gastrointestinal Tract of Acne Patients
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Thompson K, Rainer BM, Antonescu , Florea L, Mongodin E, Kang S, Chien AL
- KMID: 2467197
- Ann Dermatol.
- 2020 Feb;32(1):21-30.
- doi: 10.5021/ad.2020.32.1.21
BACKGROUND: Associations between acne and gastrointestinal comorbidities suggest that microbial dysbiosis and intestinal permeability may promote inflammatory acne, a condition often managed with oral antibiotics. OBJECTIVE: We performed a case-control study... -
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- High-risk human papillomavirus testing as a primary screening for cervical cancer: position statement by the Korean Society of Obstetrics and Gynecology and the Korean Society of Gynecologic Oncology
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Kong TW, Kim M, Kim YH, Kim YB, Kim J, Kim JW, Park MH, Park JH, Rhee JH, Lim MC, Hong JS
- KMID: 2465194
- J Gynecol Oncol.
- 2020 Jan;31(1):e31.
- doi: 10.3802/jgo.2020.31.e31
Based on emerging data and current knowledge regarding high-risk human papillomavirus (hrHPV) testing as a primary screening for cervical cancer, the Korean Society of Obstetrics and Gynecology and the Korean... -
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- Rapid detection of deformed wing virus in honeybee using ultra-rapid qPCR and a DNA-chip
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Kim JM, Lim SJ, Kim S, Kim M, Kim B, Tai TA, Kim S, Yoon B
- KMID: 2469019
- J Vet Sci.
- 2020 Jan;21(1):e4.
- doi: 10.4142/jvs.2020.21.e4
Fast and accurate detection of viral RNA pathogens is important in apiculture. A polymerase chain reaction (PCR)-based detection method has been developed, which is simple, specific, and sensitive. In this... -
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- Fluoxetine Induces Apoptotic and Oxidative Neuronal Death Associated with The Influx of Copper Ions in Cultured Neuronal Cells
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Hwang S, Kim JK
- KMID: 2468142
- Chonnam Med J.
- 2020 Jan;56(1):20-26.
- doi: 10.4068/cmj.2020.56.1.20
We examined the effect of fluoxetine, a selective serotonin reuptake inhibitor antidepressant, on neuronal viability in mouse cortical near-pure neuronal cultures. Addition of fluoxetine to the media for 24 hours... -
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- Epigenetic Changes in Asthma: Role of DNA CpG Methylation
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Bae DJ, Jun JA, Chang HS, Park JS, Park CS
- KMID: 2466615
- Tuberc Respir Dis.
- 2020 Jan;83(1):1-13.
- doi: 10.4046/trd.2018.0088
For the past three decades, more than a thousand of genetic studies have been performed to find out the genetic variants responsible for the risk of asthma. Until now, all... -
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- Comparison of 16S Ribosomal RNA Targeted Sequencing and Culture for Bacterial Identification in Normally Sterile Body Fluid Samples: Report of a 10-Year Clinical Laboratory Review
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Yoo IY, Kang OK, Lee MK, Kim YJ, Cho SY, Huh K, Kang CI, Chung DR, Peck KR, Huh HJ, Lee NY
- KMID: 2457495
- Ann Lab Med.
- 2020 Jan;40(1):63-67.
- doi: 10.3343/alm.2020.40.1.63
As 16S ribosomal RNA (rRNA)-targeted sequencing can detect DNA from non-viable bacteria, it can be used to identify pathogens from clinical samples even in patients pretreated with antibiotics. We compared... -
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