Korean J Med.  2000 Jan;58(1):57-66.

Effect of lipoprotein lipase gene polymorphism on lipid profile and body mass index in healthy Korean adult

• Park JS
• Sung JD
• Chae IH
• Kim HS
• Ju JR
• Son DW
• Oh BH
• Lee MM
• Park YB
• Choi YS
• Lee YW

Abstract

BACKGROUND: Lipoprotein lipase(LPL) plays a pivotal role in triglyceride-rich lipoprotein metabolism. It removes TG-rich lipoprotein from circulation by hydrolysing TG and produces active form of HDL. It also affects the development and maintenance of obesity by regulating the fatty acid metabolism of the adipose tissue. Many studies about the association of the genetic variation of LPL and dyslipidemia have been performed, but the results were not consistent. We tried to characterize the phenotypes of the LPL genetic variation in Korean.
METHODS
Healthy Korean adults (n=110) were genotyped for Hind III/Pvu II RFLP and Ser447Ter mutation of the LPL gene by PCR-digestion method. We investigated the association of the genetic variations with the lipids, the lipoprotein concentrations and the body mass index(BMI).
RESULTS
The allele frequencies of Hind III RFLP, Pvu II RFLP and Ser447Ter mutation were H1:H2=33%:67%, P1:P2=40%:60% and Ser447: Ter447=90%:10%. Ser447Ter mutation carriers had higher HDL cholesterol level than non-carriers (59+/-10mg/dl versus 53+/-11mg/dl, p=0.049) and the Pvu II RFLP is associated with increased body mass index. (P1P1:P1P2:P2P2 = 22.1+/-2.0 kg/m2: 23.5+/-2.7 kg/m2: 24.5+/-2.6 kg/m2, p=0.003)
CONCLUSION
The genetic variations of the LPL gene in healthy Korean adult resulted in increased HDL cholesterol and increased BMI. These results were different from previous studies. This difference may reflect the racial difference from the diet and the linkage disequilibrium

Keyword

Lipoprotein lipase; Ser447Ter mutation; Pvu II; Hind III; Body mass index; HDL cholesterol

MeSH Terms

Adipose Tissue
Adult*
Body Mass Index*
Cholesterol, HDL
Diet
Dyslipidemias
Gene Frequency
Genetic Variation
Humans
Linkage Disequilibrium
Lipoprotein Lipase*
Lipoproteins*
Metabolism
Obesity
Phenotype
Polymorphism, Restriction Fragment Length
Cholesterol, HDL
Lipoprotein Lipase
Lipoproteins