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Evaluation of the antimalarial activity of SAM13-2HCl with morpholine amide (SKM13 derivative) against antimalarial drug-resistant Plasmodium falciparum and Plasmodium berghei infected ICR mice

Hong H, Moon K, Trinh TTT, Eom TH, Park H, Kim HS, Yeo SJ

Antimalarial drugs are an urgently need and crucial tool in the campaign against malaria, which can threaten public health. In this study, we examined the cytotoxicity of the 9 antimalarial...
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Development of an Instrument for Slit-lamp Examination of Donor Corneas in Preservation Medium

Nam GH, Kim DR, Yoon YC, Yang SW, Whang WJ, Byun YS, Hwang HB, Na KS, Lee HS, Chung SH, Kim EC, Cho YK, Kim HS, Hwang HS

Purpose: To evaluate the effectiveness of an instrument devised for slit-lamp examination of donor corneas suspended in preservation medium. Methods: The study examined two donor corneas received at Yeouido St. Mary's...
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Prediction model of health-related quality of life in older adults according to gender using a decision tree model: a study based on the Korea National Health and Nutrition Examination Survey

Kim HS, Jeong SH

Purpose: The aim of this study was to predict the subgroups vulnerable to poorer health-related quality of life (HRQoL) according to gender in older adults. Methods: Data from 5,553 Koreans aged...
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Promising Effect of the Children in Disaster: Evaluation and Recovery Intervention on Trauma Symptoms and Quality of Life for Children and Adolescents: A Controlled Study

Park EJ, Lee MS, Bae SM, Kim HS, Hong M, Kim E, Lee SK, Kim J, Bhang SY

Objective The Children in Disaster: Evaluation and Recovery (CIDER) program in Korea was developed to treat children and adolescents exposed to trauma. This study aimed to demonstrate the effectiveness of...
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Categorization of Meibomian Gland Dysfunction Using Lipid Layer Thickness and Meibomian Gland Dropout in Dry Eye Patients: A Retrospective Study

Lee PK, Chung JL, Kim DR, Yoon YC, Yang S, Whang WJ, Byun YS, Hwang H, Na KS, Lee H, Chung SH, Kim EC, Cho Y, Kim HS, Hwang HS

Purpose: In the present study, we determined the prevalence of obstructive meibomian gland dysfunction (MGD), hyposecretory MGD, grossly normal MG, and hypersecretory MGD in patients with dry eye syndrome using...
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Prediction of Cardiovascular Complication in Patients with Newly Diagnosed Type 2 Diabetes Using an XGBoost/GRU-ODE-Bayes-Based Machine-Learning Algorithm

Lee J, Choi Y, Ko T, Lee K, Shin J, Kim HS

Background: Cardiovascular disease is life-threatening yet preventable for patients with type 2 diabetes mellitus (T2DM). Because each patient with T2DM has a different risk of developing cardiovascular complications, the accurate...
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Diverse perspectives on remote collaborative care for chronic disease management

Baik SY, Park H, Shinn J, Kim HS

Remote collaborative care is a program that improves medical services by linking local and remote physicians with residents in areas where access to medical facilities is limited, utilizing information and...
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Current status of remote collaborative care for hypertension in medically underserved areas

Baik SY, Kim KM, Park H, Shinn J, Kim HS

Background: Remote collaborative care (ReCC) is a legally recognized form of telehealth that facilitates communication between physicians. This study aimed to analyze the effectiveness of ReCC services and establish a...
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Using medical big data for clinical research and legal considerations for the protection of personal information: the double-edged sword

Kim R, Shinn J, Kim HS

The advent of medical big data has increased the scope of the clinical use of such data; however, these data have raised serious concerns regarding personal privacy protection, which hinders...
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Successful diagnosis and treatment of recurrent atypical hemolytic uremic syndrome posttransplantation caused by the heterozygous deletion of CFH in a patient with end-stage kidney disease of uncertain etiology

Lee H, Kim HS, Lee H, Eum SH, Sun IO, Shin J, Choi YJ, Yang CW, Kim M, Chung BH

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Adolescent Screen Use: Problematic Internet Use and the Impact of Gender

Niskier SR, Snaychuk LA, Kim HS, da Silva TT, de Souza Vitalle MS, Tavares H

Objective The relationship between screen use and problematic internet use (PIU; i.e., internet addiction) amongst adolescents has not been sufficiently explored. Further, there is even less research on how gender...
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Histologic features and predicting prognosis in ulcerative colitis patients with mild endoscopic activity

Shin SY, Kim HS, Kim K, Choi CW, Moon JM, Kim JW, Joo HJ, Seo J, Sung M, Choi CH

Background/Aims: We aimed to evaluate the histologic features predictive of prognosis and correlate them with endoscopic findings in patients with ulcerative colitis (UC) having complete or partial mucosal healing (MH). Methods:...
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Caregiver Burden of Patients With Huntington’s Disease in South Korea

Lee CY, Shin C, Hwang YS, Oh E, Kim M, Kim HS, Chung SJ, Sung YH, Yoon WT, Cho JW, Lee JH, Kim HJ, Chang HJ, Jeon B, Woo KA, Koh SB, Kwon KY, Moon J, Kim YE, Lee JY

Objective This is the first prospective cohort study of Huntington’s disease (HD) in Korea. This study aimed to investigate the caregiver burden in relation to the characteristics of patients and...
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First-in-Human Phase 1 Study of a B Cell– and Monocyte-Based Immunotherapeutic Vaccine against HER2-Positive Advanced Gastric Cancer

Jung M, Lee JB, Kim HS, Kwon WS, Kim HO, Kim S, Park M, Kim W, Choi KY, Oh T, Kang CY, Chung HC, Rha SY

Purpose BVAC-B is an autologous B cell– and monocyte-based immunotherapeutic vaccine that contains cells transfected with a recombinant human epidermal growth factor receptor 2 (HER2) gene and loaded with the...
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Maturity-onset diabetes of the young due to NR0B2 gene mutation

Lee HI, Kwon SS, Lee M, Kim SJ, Song K, Kwon A, Chae HW, Kim HS, Suh J

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Short stature with low serum alkaline phosphatase activity: a case report of hypophosphatasia

Lee D, Park SY, Kim HS, Kang S

Hypophosphatasia (HPP) is a rare condition characterized by abnormal bone mineralization. The manifestations of HPP vary from no symptoms to intrauterine fetal death; short stature is another indication of HPP....
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Lateral medullary infarction in a patient with Moyamoya disease associated with RNF213 variants: a case report

Roh YJ, Lee KO, Kim HS

Background: Moyamoya disease (MMD) is a rare cerebrovascular disease radiologically characterized by progressive bilateral occlusion of the distal portion of the internal carotid artery and compensating collaterals. Herein, we report...
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Is restrictive transfusion sufficient in colorectal cancer surgery? A retrospective study before and during the COVID-19 pandemic in Korea

Kim HK, Kim HS, Noh GT, Nam JH, Chung SS, Kim KH, Lee RA

Purpose: Blood transfusion is one of the most common procedures used to treat anemia in colorectal surgery. Despite controversy regarding the adverse effects of blood products, surgeons have maintained standards...
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Clinical Analysis of Repeat Balloon Eustachian Tube Dilatation

Lee GK, Kim Hs, Kim H, Lee Jw, Oh Sj, Kong Sk

Background and Objectives Obstructive Eustachian tube dysfunction (OETD) is a complex condition in which middle ear ventilation control is impaired. OETD is often not improved by medication nor by nasal...
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Preclinical Study of Dual-Wavelength Light-Emitting Diode Therapy in an Osteoarthritis Rat Model

Choi WW, Kim SH, Kim JH, Kim K, Kim SJ, Kim M, Kim HS, Lee H, Lee JY, Yong SY

Objective: To evaluate the efficacy of light-emitting diode (LED) and their dual-wavelengths as a treatment strategy for osteoarthritis. Methods: We induced osteoarthritis in male Sprague-Dawley rats by intra-articular injection of sodium...
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