J Korean Soc Endocrinol.  2006 Aug;21(4):311-318. 10.3803/jkes.2006.21.4.311.

Relationship between Childhood and Adolescent Obesity and Remnant Lipoprotein

• Choi YJ
• Jo YE
• Kim YK
• Ahn SM
• Baik SH
• Jung SH
• Kim HJ
• Chung YS
• Lee KW
• Kim DJ

• KMID: 2200846
• DOI: http://doi.org/10.3803/jkes.2006.21.4.311

Abstract

BACKGROUND: Remnant lipoproteins are the lipolytic degradation product of the triglyceride-rich lipoproteins produced by the liver (very-low-density lipoprotein cholesterol) and intestine (chylomicrons). Recent studies have demonstrated a correlation between remnant lipoproteins and cardiovascular risk. Our study assessed the relationship between obesity and remnant lipoproteins and evaluated the factors related to remnant lipoprotein in children and adolescents.
METHODS
Body mass index (BMI), waist circumference, systolic and diastolic blood pressures, body fat mass, total abdominal fat, visceral and subcutaneous fat areas, total cholesterol, triglyceride (TG), LDL cholesterol (LDL-C), HDL cholesterol (HDL-C) and remnant lipoprotein cholesterol (RLP-C) were measured in 135 children and adolescents (67 boys and 68 girls). Plasma RLP fractions were isolated using an immunoaffinity gel containing specific anti-apoB-100 and anti-apoA-I antibodies. The subjects were divided into three groups: the low (< 50 percentile), mid (50~84 percentile), and high (> or = 85 percentile) BMI groups.
RESULTS
RLP-C was significantly correlated with age, sex, BMI, waist circumference, systolic and diastolic blood pressures, visceral and subcutaneous fat areas, visceral fat area to subcutaneous fat area ratio (VSR), total cholesterol, TG, HDL-C, apoB, and HOMA-IR. From a multivariate regression analysis, TG (beta = 0.928, P < 0.001) was found to be independently correlated with RLP-C. After excluding TG as an independent variable, a multivariate regression analysis revealed that the HOMA-IR (beta=0.231, P=0.007) and systolic blood pressure (beta=0.169, P=0.046) were independently associated with RLP-C.
CONCLUSION
RLP-C was significantly higher in obese children and adolescents. TG, systolic blood pressure, and insulin resistance were related to remnant lipoproteins.

MeSH Terms

Abdominal Fat
Adipose Tissue
Adolescent*
Antibodies
Apolipoproteins B
Blood Pressure
Body Mass Index
Child
Cholesterol
Cholesterol, HDL
Cholesterol, LDL
Dyslipidemias
Humans
Insulin Resistance
Intestines
Intra-Abdominal Fat
Lipoproteins*
Liver
Obesity
Pediatric Obesity*
Plasma
Subcutaneous Fat
Triglycerides
Waist Circumference
Antibodies
Apolipoproteins B
Cholesterol
Cholesterol, HDL
Cholesterol, LDL
Lipoproteins

Figure

• 

  Fig. 1 The frequency of subjects showing the high levels (≥ 7.5 mg/dL) of remnant lipoprotein cholesterol (RLP-C) according to the body mass index (BMI) percentile (P) groups (P = 0.023).

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