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Urine-derived stem cell attenuated renal fibrosis via Klotho activation

Shin JA, Lee EJ, Ham YR, Kim HR, Jeon JW, Lee KW, Na KR, Choi DE

Background: After renal ischemia reperfusion injury (IR), regeneration and recovery of the renal tubular cell occurs. However, if the renal repair process is maladaptive, it progresses to renal fibrosis. The...
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Preclinical xeno-kidney transplantation of pig to cynomolgus non-human primate: 2 years of experience

Park SW, Kim DS, Park JB, Lee KW, Kwon GY, Choi K, Yan JJ, Yang J, Kim SJ

Background: Xenotransplantation is gaining much attention as an alternative means to resolve the worldwide organ shortage. Pigs are currently considered the best donor animal, and recent clinical application of kidney...
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Comparison between continuous versus intermittent infusion of human antithrombin III concentrate in the immediate postoperative period after liver transplantation

Kim BR, Oh J, Lim L, Sohn 2 JY, Choi Y, Yi NJ, Lee KW, Suh KS, Ryu HG

Background: Antithrombin-III (AT-III) concentrates have been used in the immediate postoperative period after liver transplantation to prevent critical thrombosis. In the preceding study that retrospectively analyzed the pharmacokinetics of AT-III...
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Histopathologic evaluations on porcine vessel lacking GGTA1/CMAH/ β4galNT2/iGb3 genes in non-human primate xenotransplantation

Chung YS, Lee KW, Choi M, Shim J, Choi K, Kim SJ, Park JB, Kim TJ

Background: Although alpha-galactosyltransferase knock out (GTKO) pigs overcome the hyper-acute-rejection in pig to non-human primate (NHP) xenotransplantation, it still remains severe acute humoral xenograft rejection. HD and Sda as non-Gal...
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Pattern of porcine cytomegalovirus detection and its association with recipient survival following renal xenotransplantation in non-human primate preclinical study

Park SW, Kim DS, Choi K, Park JB, Lee KW, Cho B, Kim SJ

Background: With growing interest in xenotransplantation to resolve the worldwide organ shortage, a considerable progress in the prevention of immunological rejection has been made using genetic modifications of pig that...
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Feasible living donor liver transplantation for patients on chronic hemodialysis: a multicenter study in Eastern countries

Furukawa K, Hong SK, Shimata K, Ito S, Toshima T, Akamatsu N, Kasahara M, Ikegami T, Lee KW

Background: End-stage liver and kidney disease is an indication for simultaneous liver and kidney transplantation. However, in countries where deceased donor transplantation has not developed, patients on hemodialysis (HD) are...
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The effect of steroid pulse therapy for the reduction of acute rejection episode in subclinical borderline changes: an open-label, randomized clinical trial

Jeong E, Lee KW, Lim M, Yang J, Kwon JE, Park JB

Background: Subclinical rejection (SCR) has been correlated with subsequent chronic allograft nephropathy and allograft dys-function. SCR is known to be effective in steroid pulse therapy (SPT) in other studies. However,...
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Intraoperative hepatic artery thrombosis in living donor liver transplantation despite immediate reconstruction increases risk of graft failure

Hong SY, Lee JM, Hong SK, Choi Y, Jin US, Chang H, Lee KW, Suh KS

Background: Posttransplant hepatic artery thrombosis (HAT) can lead serious complications of are derived from long arterial ischemic time. However, there has been few reports regarding fate of intraoperative HAT during...
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Group analysis of outcomes after liver transplant in patients aged 70 years or older

Kim J, Choi Y, Suh KS, Lee KW, Yi NJ, Hong SK, Lee JM, Hong Sy, Lee S

Background: Liver transplantation (LT) in the elderly requires caution because of its low survival and high morbidity. Since the definition of the elderly beneficiary was unclear, the base age was...
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Impact of allocation priority for children awaiting liver transplantation: a pediatric liver allocation simulated model analysis

Lee J, Choi Y, Yi NJ, Kim J, Kim J, Lee S, Hong Sy, Hong SK, Lee KW, Suh KS

Background: Deceased donor pool in pediatric liver transplantation (LT) had increased temporarily for several years since allocation and registration policies of split LT were amended by the Korean Network for...
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Mammalian target of rapamycin inhibitor attenuates warm ischemic biliary injury (rat model)

Choi HH, Lee KW, Suh KS, Yi NJ, Choi Y, Hong SK, Hong Sy, Lee S, Kim JY, Lee J

Background: The purpose of this study was to establish a model of warm ischemic biliary injury and evaluate the effects of immunosuppressants (IS) on biliary stricture using this model. Methods: Fifty...
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Intraoperative aborted living donor liver transplantation surgeries, lessons from 13,937 cases of Vanguard multi-center study of international living donor liver transplantation group

Toshima T, Lee KW, Rhu J, Yoon YI, Ito T, Uchida H, Hong SK, Reddy MS, Ikegami T, Yoshizumi T

Background: We rarely experience these situations where intraoperative abortions are inevitable in living donor liver transplan-tation (LDLT) by unexpected or catastrophic events in the real world. To date, there has...
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End-to-side jump graft from superior mesenteric vein for portal vein reconstruction in pediatric liver transplantation: a case report

Lee J, Yi NJ, Kim J, Choi HH, Lee S, Hong SY, Hong SK, Choi Y, Lee KW, Suh KS

Attenuated portal vein (PV) flow is challenging in pediatric liver transplantation (LT) because the PV size of a large-for-size graft is unsuitable even for an end-to-end jump vein graft from...
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Swine partial liver transplantation model for practicing living donor liver transplantation based on a new liver segmentation method

Lee J, Cho JH, Lee KW, Yi NJ, Choi Y, Hong SK, Lee JM, Hong SY, Lee S, Suh KS

Background: Living donor liver transplantation (LDLT) is one of the most technically demanding and complicated procedures. However, unlike deceased donor liver transplantation, there is no suitable animal model for practicing...
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Long-term survival outcome beyond the 1st year of pediatric acute liver failure after liver transplantation compared with biliary atresia: a large-volume living donor liver transplantation single-center study

Lee S, Yi NJ, Hong SY, Hong SK, Choi Y, Kim HY, Moon JS, Yang SM, Lee KW, Suh KS

Background: Pediatric acute liver failure (PALF) is the second most common cause for liver transplantation (LT) in children, but its outcomes are the worst. The purpose of this study is...
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Biliary nonanastomosis stricture related with hepatic congestion in the right liver graft

Choi HH, Choi Y, Suh KS, Lee KW, Yi NJ, Hong SK, Hong SY, Lee S, Lee J, Kim J

Background: Biliary nonanastomosis stricture (NAS) and passive hepatic congestion are common complications after living do-nor liver transplantation (LDLT). The former is known to be caused by ischemic cholangiopathy and the...
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Outcome of total necrosis of hepatocellular carcinoma after liver transplantation: is it really totally gone?

Kim J, Hong SK, Lee S, Hong S, Lee JM, Choi Y, Yi NJ, Lee KW, Suh KS

Background: Total necrosis of hepatocellular carcinoma (HCC) by locoregional treatment (LRT) is considered to have no tumor viability. Nonetheless, there is no sufficient evidence of recurrence prevalence after liver transplantation....
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Risk factors of incisional hernia after liver transplantation in the era of mammalian target of rapamycin inhibitors combined usage

Kim J, Hong SK, Suh KS, Lee KW, Yi NJ, Choi Y, Lee JM, Hong Sy, Lee S

Background: Incisional hernia (IH) is a common complication after liver transplantation (LT) with an incidence of 5% to 46%. The purpose of this retrospective study was to evaluate the risk...
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Clinical effectiveness of live attenuated herpes zoster vaccine in kidney transplant recipients immunized prior to kidney transplantation: a retrospective single-center cohort study

Kim SH, Huh K, Lee KW, Park JB, Huh WS, Ko JH, Peck KR

Background: Kidney transplant recipients have an increased risk of herpes zoster (HZ) and its complications. Although live attenuated or recombinant subunit zoster vaccine has been recommended for candidates for kidney...
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Prevalence of hepatopulmonary shunt in agitated saline test and lung perfusion scan and predictive value of arterial oxygenation

Lee S, Lee KW, Choi HH, Kim J, Hong Sy, Choi Y, Yi NJ, Suh KS, Lee J, Kim JY

Background: Hepatopulmonary syndrome is defined as arterial deoxygenation in cirrhotic patient with intrapulmonary vasodilatation evident in contrast-enhanced echocardiography or lung perfusion scan. Prevalence is reported to be around 5%–35%, and...
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