J Korean Neurosurg Soc.
2015 Feb;57(2):82-87. 10.3340/jkns.2015.57.2.82.
Impaired Voluntary Wheel Running Behavior in the Unilateral 6-Hydroxydopamine Rat Model of Parkinson's Disease
- Affiliations
-
- 1Department of Neurosurgery, Zhujiang Hospital, Southern Medical University, Guangzhou, China. ruxiangcd@126.com
- 2Key Laboratory on Brain Function Repair and Regeneration of Guangdong, Southern Medical University, Guangzhou, China.
- 3Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.
- 4Neuroscience Research Institute of North Carolina, Winston-Salem, NC, USA.
- 5Department of Neurosurgery, The Military General Hospital of Beijing PLA, Beijing, China.
- KMID: 2191187
- DOI: http://doi.org/10.3340/jkns.2015.57.2.82
Abstract
OBJECTIVE
The aim of this study was to investigate voluntary wheel running behavior in the unilateral 6-hydroxydopamine (6-OHDA) rat model.
METHODS
Male Sprague-Dawley rats were assigned to 2 groups : 6-OHDA group (n=17) and control group (n=8). The unilateral 6-OHDA rat model was induced by injection of 6-OHDA into unilateral medial forebrain bundle using a stereotaxic instrument. Voluntary wheel running activity was assessed per day in successfully lesioned rats (n=10) and control rats. Each behavioral test lasted an hour. The following parameters were investigated during behavioral tests : the number of running bouts, the distance moved in the wheel, average peak speed in running bouts and average duration from the running start to the peak speed.
RESULTS
The number of running bouts and the distance moved in the wheel were significantly decreased in successfully lesioned rats compared with control rats. In addition, average peak speed in running bouts was decreased, and average duration from the running start to the peak speed was increased in lesioned animals, which might indicate motor deficits in these rats. These behavioral changes were still observed 42 days after lesion.
CONCLUSION
Voluntary wheel running behavior is impaired in the unilateral 6-OHDA rat model and may represent a useful tool to quantify motor deficits in this model.
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