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Animal model evaluation of a novel renal denervation system for future laparoscopic treatment of resistant hypertension

Song WH, Baik J, Yang S, Choi EK, Park SM, Jeong CW

PURPOSE: Although percutaneous catheter-based ablation of renal sympathetic nerve fibers has been used in the treatment of patients with resistant hypertension, a recent phase III study did not confirm its...
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Treatment with low-energy shock wave alleviates pain in an animal model of uroplakin 3A-induced autoimmune interstitial cystitis/painful bladder syndrome

Li H, Zhang Z, Peng J, Xin Z, Li M, Yang B, Fang D, Tang Y, Guo Y

PURPOSE: To investigate whether treatment with low-energy shock wave (LESW) alleviates pain and bladder dysfunction in a mouse model of uroplakin 3A (UPK3A)-induced interstitial cystitis/painful bladder syndrome (IC/PBS). MATERIALS AND METHODS:...
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Effect of gemigliptin on cardiac ischemia/reperfusion and spontaneous hypertensive rat models

Nam DH, Park J, Park SH, Kim KS, Baek EB

Diabetes is associated with an increased risk of cardiovascular complications. Dipeptidyl peptidase-4 (DPP-IV) inhibitors are used clinically to reduce high blood glucose levels as an antidiabetic agent. However, the effect...
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Effect of Ambrisentan Therapy on the Expression of Endothelin Receptor, Endothelial Nitric Oxide Synthase and NADPH Oxidase 4 in Monocrotaline-induced Pulmonary Arterial Hypertension Rat Model

Lee H, Yeom A, Kim KC, Hong YM

BACKGROUND AND OBJECTIVES: Elevated endothelin (ET)-1 level is strongly correlated with the pathogenesis of pulmonary arterial hypertension (PAH). Expression level of nicotinamide adenine dinucleotide phosphate oxidase (NOX) 4 is increased...
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Quantitative Evaluation of Hepatic Steatosis Using Normalized Local Variance in a Rat Model: Comparison with Histopathology as the Reference Standard

Bae JS, Lee JY, Lee DH, Kim H, Lee Y, Han JK

OBJECTIVE: To evaluate the diagnostic performance of the normalized local variance (NLV) ultrasound technique in the assessment of hepatic steatosis, and to identify the factors that influence the NLV value...
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Effects of dexamethasone and hydrocortisone on rocuronium-induced neuromuscular blockade and reversal by sugammadex in phrenic nerve-hemidiaphragm rat model

Choi H, Park SY, Kim YB, In J, Yang HS, Lee JS, Kim S, Park S

BACKGROUND: The facilitator effects of steroids on neuromuscular transmission may cause resistance to neuromuscular blocking agents. Additionally, steroids may hinder sugammadex reversal of neuromuscular blockade, but these findings remain controversial....
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Influence of Short- and Long-term High-dose Caffeine Administration on Behavior in an Animal Model of Adolescence

Park JM, Kim Y, Kim H, Kim YJ

PURPOSE: Caffeine is the most widely consumed psychostimulant of the methylxanthine class. Among adolescents, high-dose of caffeine consumption has increased rapidly over the last few decades due to the introduction...
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Therapeutic Effect of 308-nm Excimer Laser on Alopecia Areata in an Animal Model

Moon JH, Bang CY, Kang MJ, Yeom SD, Yoon HS, Kim HJ, Byun JW, Shin J, Choi GS

No abstract available.
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Polydeoxyribonucleotides Improve Diabetic Wound Healing in Mouse Animal Model for Experimental Validation

Kwon TR, Han SW, Kim JH, Lee BC, Kim JM, Hong JY, Kim BJ

BACKGROUND: Wound healing mechanisms is believed to have effects similar to wound healing disorders in diabetic patients, including abnormal inflammatory cells, angiogenesis disorders, and reduced collagen synthesis. Therefore, reestablishment of...
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Adipose Tissue-Derived Stem Cell Therapy for Cavernous Nerve Injury-Induced Erectile Dysfunction in the Rat Model: A Systematic Review and Meta-Analysis Using Methodological Quality Assessment

Park HJ, Jeong H, Park YH, Yim HW, Ha US, Hong SH, Kim SW, Kim NJ, Lee JY

BACKGROUND AND OBJECTIVES: Few studies were evaluated the effect of blindness on outcome in animal models, though a potential effect of blinding has been reported in clinical trials. We evaluated...
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Synergistic effects of extracorporeal shockwave therapy and modified Ojayeonjonghwan on erectile dysfunction in an animal model of diabetes

Jeong HC, Bae WJ, Zhu GQ, Jeon SH, Choi SW, Kim SJ, Cho HJ, Hong SH, Lee JY, Hwang SY, Kim SW

PURPOSE: We investigated the synergy effect of extracorporeal shock wave therapy (ESWT) with modified Ojayeonjonghwan (Korean herbal formula, KH-204) in an animal model of diabetes mellitus (DM)-induced erectile dysfunction (ED). MATERIALS...
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Supplementation with psyllium seed husk reduces myocardial damage in a rat model of ischemia/reperfusion

Lim SH, Lee J

BACKGROUND/OBJECTIVES: Myocardial infarction (MI) is caused by extensive myocardial damage attributed to the occlusion of coronary arteries. Our previous study in a rat model of ischemia/reperfusion (I/R) demonstrated that administration...
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Effect of Pyunkang-tang on Inflammatory Aspects of Chronic Obstructive Pulmonary Disease in a Rat Model

Seo HS, Lee HJ, Lee CJ

We investigated the anti-inflammatory effect of Pyunkang-tang extract (PGT), a complex herbal extract based on traditional Chinese medicine that is used in Korea for controlling diverse pulmonary diseases, on cigarette...
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Effect of Ghrelin on Memory Impairment in a Rat Model of Vascular Dementia

Park JM, Kim YJ

PURPOSE: The purpose of this study was to identify the effect of ghrelin on memory impairment in a rat model of vascular dementia induced by chronic cerebral hypoperfusion. METHODS: Randomized controlled...
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The Evaluation of Exogenous Melatonin Administration in Supraspinatus Overuse Tendinopathy in an Experimental Rat Model

Kocadal O, Pepe M, Akyurek N, Gunes Z, Surer H, Aksahin E, Ogut B, Aktekin CN

BACKGROUND: Increased oxidative stress and inflammation play a critical role in the etiopathogenesis of chronic tendinopathy. Melatonin is an endogenous molecule that exhibits antioxidant and anti-inflammatory activity. The aim of...
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Therapeutic Effect of Fimasartan in a Rat Model of Myocardial Infarction Evaluated by Cardiac Positron Emission Tomography with [¹⁸F]FPTP

Park H, Kim HS, Hong YJ, Min JJ, Kim HB, Kim MC, Sim DS, Kim JH, Kim DY, Lee JS, Ahn Y, Jeong MH

We evaluated the efficacy of fimasartan on perfusion defects and infarction size in an animal model of myocardial infarction (MI), with echocardiography and positron emission tomography (PET) using a ¹⁸F-labeled...
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Effect of sec-O-glucosylhamaudol on mechanical allodynia in a rat model of postoperative pain

Koh GH, Song H, Kim SH, Yoon MH, Lim KJ, Oh SH, Jung KT

BACKGROUND: This study was performed in order to examine the effect of intrathecal sec-O-glucosylhamaudol (SOG), an extract from the root of the Peucedanum japonicum Thunb., on incisional pain in a...
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Stem Cells Seeded on Multilayered Scaffolds Implanted into an Injured Bladder Rat Model Improves Bladder Function

Shrestha K, Jeon SH, Jung AR, Kim IG, Kim GE, Park YH, Kim SH, Lee JY

BACKGROUND: To investigate whether human adipose-derived stem cells (hADSCs) seeded on multilayered poly (L-lactide-co-ε-caprolactone) (PLCL) sheets improve bladder function in a rat model of detrusor smooth muscle-removed bladder. METHODS: Male rats...
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Ameliorating Effects of Electroacupuncture on Dysmotility, Inflammation, and Pain Mediated via the Autonomic Mechanism in a Rat Model of Postoperative Ileus

Murakami H, Li S, Foreman R, Yin J, Hirai T, Chen JD

  • KMID: 2449101
  • J Neurogastroenterol Motil.
  • 2019 Apr;25(2):286-299.
  • doi: 10.5056/jnm18094
BACKGROUND/AIMS: Postoperative ileus increases healthcare costs and reduces the postoperative quality of life (QOL). The aim of this study is to investigate effects and mechanisms of electroacupuncture (EA) at ST36...
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Dexmedetomidine and propofol sedation requirements in an autistic rat model

Elmorsy SA, Soliman GF, Rashed LA, Elgendy H

BACKGROUND: Autism is a challenging neurodevelopmental disorder. Previous clinical observations have suggested altered sedation requirements for children with autism. Our study aimed to test this observation experimentally in an animal...
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