- Regional Selective Loss of Neurons in 6-Hydroxydopamine Induced Lesion in the Substantia Nigra in the Rat
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Jeon BS
- KMID: 1686394
- J Korean Neurol Assoc.
- 1992 Dec;10(4):531-538.
No abstract available. -
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- Fornix Fiber Degeneration in an Experimental Animal Model of Parkinsonism using 6-Hydroxydopamine
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Jeon BS, Burke RE
- KMID: 2342393
- J Korean Neurol Assoc.
- 1994 Jun;12(2):188-192.
No abstract available. -
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- A Study on the Behavioral Properties of the Rat Parkinsonian Model
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Choi HY, Kim HI, Kim JE, Bahng IS, Lee JC
- KMID: 2187639
- J Korean Neurosurg Soc.
- 1989 Feb;18(2):205-213.
Recently the reports of the autologous grafting of adrenal medullary tissue into the brain of parkinsonian patient have given the wide attention to the neurosurgeons as well as other clinicians,... -
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- Effect of bromocriptine on 6-hydroxydopamine-induced lipid peroxidation and cytotoxicity in vitro and in vivo
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Kim YS, Maeng S, Park CW
- KMID: 2071536
- Korean J Physiol Pharmacol.
- 1998 Oct;2(5):565-572.
The present study was to evaluate the protective effects of bromocriptine, which is known as D2 dopamine receptor agonist and used for the treatment of patients with Parkinson's disease (PD), on 6-hydroxydopamine (6-OHDA)-induced... -
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- Differential Inhibition of MPP+- or 6-Hydroxydopamine-induced Cell Viability Loss in PC12 Cells by Trifluoperazine and W-7
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Lee CS
- KMID: 1600082
- Korean J Physiol Pharmacol.
- 2005 Aug;9(4):247-253.
The present study assessed the effect of calmodulin antagonists trifluoperazine and W-7 against the cytotoxicity of MPP+ and 6-hydroxydopamine (6-OHDA) in relation to the mitochondrial dysfunction and cell death in... -
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- Chronological Changes in the Rotational Behavior in Response to Apomorphine Administration in 6-Hydroxydopamine Parkinsonian Rat
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Hong KS, Kim BG, Jeon BS, Yoon BW, Lee KW, Roh JK, Lee SB, Myung HJ
- KMID: 2342760
- J Korean Neurol Assoc.
- 1999 Jan;17(1):117-121.
BACKGROUND: Apomorphine-induced rotational behavior of unilateral 6-hydroxydopamine (OHDA) lesioned rat is widely used to develop anti-Parkinsonian treatments including drugs, neuroprotective therapy, and neural graft. Time course of changes in rotational... -
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- Morphological Changes in Dopaminergic Neurons in Selective Parkinson's Rat Model
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Kim KM, Kim YS
- KMID: 2067354
- J Korean Neurosurg Soc.
- 1996 Jan;25(1):16-22.
The great majority of studies on tissue implantation in Parkinson's rat models have been performed. Recently the new rat model which is similar to clinical Parkinson's disease was developed. The... -
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- An Autoradiographic Study on the Rat Neostriatal Dopamine Receptor Changes after 6-hydroxydopamine Injection into the Medial Prefrontal Cortex
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Kwon JS, Lee DY, Woo JI
- KMID: 2340296
- J Korean Neuropsychiatr Assoc.
- 1999 Mar;38(2):408-418.
The frontal cortex of rat is innervated by dopaminergic pathway(mesocortical pathway) arising from ventral tegmental area. Several studies have suggested that mesocortical dopaminergic neurons may modulate the function of dopaminergic... -
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- The Significance of Apomorphine-Induced Rotational Behavior in Partial Lesioned Rat Parkinsonian Models with 6-hydroxydopamine
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Park YG, Shin HS, Chang JW, Chung SS
- KMID: 2010225
- J Korean Neurosurg Soc.
- 1996 Mar;25(3):483-492.
An apomorphine-induced rotational test has been used in the evaluation of rat parkinsonian models lesioned with neurotoxin 6-hydroxydopamine (6-OHDA). Previous parkinsonian rat models have generally been characterized by unilateral destruction... -
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- Effects of 6-hydroxydopamine on the Adult Neurogenesis of Dopaminergic Neurons in the Mouse Midbrain
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Kim TW, Kim H, Sun W
- KMID: 2165293
- Exp Neurobiol.
- 2009 Jun;18(1):26-31.
- doi: 10.5607/en.2009.18.1.26
Recently, restricted progenitor cells have been identified in the substantia nigra (SN) of the rat and mouse, raising a hope that resident stem/progenitor cells may be useful for the therapy... -
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- Effects of Fetal Nondopaminergic Cortical Tissue Transplantation in the Rat Parkinsonian Model
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Chang JW, Chung SS
- KMID: 1954681
- J Korean Neurosurg Soc.
- 1994 May;23(5):487-498.
Fetal dopaminergic or nondopaminergic cortical tissues were implanted directly into the denervated striatum of partial lesioned rat parkinsonian models. After transplantation, at rats were behaviourally tested with apomorphine and sacrificed... -
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- Effect of Repeated Graft of Fetal Mesencephalic Cells in 6-Hydroxydopamine Rat Model of Hemiparkinsonism
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Han DH, Oh CW, Kim YS, Park CW
- KMID: 1956071
- J Korean Neurosurg Soc.
- 1999 Sep;28(9):1249-1256.
OBJECTIVE: In this experimental study, authors evaluated the effect of repeated graft of the fetal midbrain cells on rat model of hemiparkinsonism. MATERIALS AND METHODS: Following injection of the 6-hydroxydopamine into... -
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- Changes of Neuropeptides in the Basal Ganglia of Hemiparkinsonian Rat Model
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Park KW, Lee DH, Park MK, Kim BJ, Ko SB, Suh YS
- KMID: 1957292
- J Korean Neurol Assoc.
- 1994 Dec;12(4):604-613.
We used in situ hybridization histochemistry with synthetic oligonucleotide probes to examined the effects of unilateral 6-hydroxydopamine lesions (which eliminated tyrosine hydroxylase mRNA containing cells in mesencephalon) on enkephalin, dynorphin,... -
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- Medaka Fish Parkinson's Disease Model
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Matsui H, Gavinio R, Takahashi
- KMID: 2134999
- Exp Neurobiol.
- 2012 Sep;21(3):94-100.
- doi: 10.5607/en.2012.21.3.94
The teleost fish has been widely used in creating neurodegenerative models. Here we describe the teleost medaka fish Parkinson's disease (PD) models we developed using toxin treatment and genetic engineering.... -
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- Ectopic Tyrosine Hydroxylase-immunoreactive Neurons in the 6-OHDA-lesioned Striatum in Neonatal Rat
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Hann HJ
- KMID: 1514930
- Korean J Anat.
- 2003 Apr;36(2):89-98.
Tyrosine hydroxylase-immunoreactive (TH-IR) neurons are known to exist in the substantia nigra pars compacta (SNpc), but not in the striatum in normal rats. In this study, injection of 6-OHDA into... -
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- Relationship between Microglial Activation and Dopaminergic Neuronal Loss in 6-OHDA-induced Parkinsonian Animal Model
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Lee JS, Lee JY, Cho WG, Yang YC, Cho BP
- KMID: 1430195
- Korean J Phys Anthropol.
- 2013 Mar;26(1):13-23.
- doi: 10.11637/kjpa.2013.26.1.13
This study assessed the dynamics of morphological and immunophenotypic properties of activated microglia in a 6-hydroxydopamine (6-OHDA) induced Parkinsonian animal model. Neurodegeneration in the substantia nigra pars compacta (SNc) was... -
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- Tumor Necrosis Factor-Associated Protein 1 (TRAP1) is Released from the Mitochondria Following 6-hydroxydopamine Treatment
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Shin DI, Oh YJ
- KMID: 2009026
- Exp Neurobiol.
- 2014 Mar;23(1):65-76.
- doi: 10.5607/en.2014.23.1.65
Parkinson's disease (PD) is a common neurodegenerative disorder characterized by progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta. Most cases are sporadic and its etiology is incompletely... -
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- Spinal Noradrenergic Modulation and the Role of the Alpha-2 Receptor in the Antinociceptive Effect of Intrathecal Nefopam in the Formalin Test
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Jeong SH, Heo BH, Park SH, Kim WM, Lee HG, Yoon MH, Choi JI
- KMID: 2278198
- Korean J Pain.
- 2014 Jan;27(1):23-29.
- doi: 10.3344/kjp.2014.27.1.23
BACKGROUND: Nefopam has shown an analgesic effect on acute pain including postoperative pain. The reuptake of monoamines including serotonin and noradrenaline has been proposed as the mechanism of the analgesic... -
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- Noradrenergic Changes in an Experimental Model of Parkinsonism Using 6-hydroxydopamine
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Jeon BS
- KMID: 2342515
- J Korean Neurol Assoc.
- 1996 Jun;14(2):448-454.
BACKGROUND & OBJECTIVE: Stereotaxic injection of 6-hydroxydopamine(6OHDA) into the ventral midbrain is the most commonly used Parkinsonian animal model. In the presence of norepinephrine(NE) uptake blockers, 6OHDA is believed to... -
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- Cytotoxic Effect of 6-OHDA on the Dopaminergic Neurons and Astrocytes in the Dorsal Raphe Nucleus of the Rat
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Hong ES, Nam SA, Jo SM, Kang TC, Won MH, Choi CD
- KMID: 2040100
- Korean J Anat.
- 1999 Aug;32(4):553-561.
This study was designed to clarify the cytotoxic effects of 6-hydroxydopamine (6-OHDA) on the dopaminergic neurons and astrocytes in the dorsal raphe nucleus (DRN), and to investigate neurodegenerative changes by... -
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