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Enhancing the Effect of Placental Extract on the Regeneration of Crush Injured Facial Nerve

Lim GM, Cho GW, Ganesan CD, Choi JH, Ang MJ, Moon C, Jang CH

  • KMID: 2537961
  • Exp Neurobiol.
  • 2022 Dec;31(6):419-430.
  • doi: 10.5607/en22006
There is a scarcity of experimental studies on peripheral nerve regeneration using placental extract (PE). This study aimed to investigate the effects of topical PE application on recovery after crush...
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Morphological, ultrastructural, and biochemical changes induced by sodium fluoride in the tongue of adult male albino rat and the ameliorative effect of resveratrol

El-Bestawy EM, Tolba AM, Rashad WA

Little knowledge is available about the effects of fluoride exposure on the tongue. This study evaluated the effects of sodium fluoride (NaF) on the tongue ultrastructure and detected the ameliorative...
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Temporal Modulation of DNA Methylation and Gene Expression in Monolayer and 3D Spheroids of Dental Pulp Stem Cells during Osteogenic Differentiation: A Comparative Study

Raik S, Thakur R, Rattan V, Kumar N, Pal A, Bhattacharyya S

BACKGROUND: Human mesenchymal stem cells are being used for various regenerative applications in past decades. This study chronicled a temporal profile of the transcriptional pattern and promoter methylation status of the...
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Delayed-Onset Perforating Phenomenon in a Patient with Sorafenib-Induced Psoriasiform Eruption

Song CH, Song SY, Kim JE, Ro YS, Ko JY

  • KMID: 2536330
  • Korean J Dermatol.
  • 2022 Nov;60(9):628-630.
Sorafenib is an inhibitor of receptor tyrosine kinases and the rat sarcoma/mitogen-activated protein kinase (RAS/MAPK) pathway that is approved for the treatment of patients with metastatic hepatocellular carcinoma (HCC) and...
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Enhancement of bioactivity and osseointegration in Ti-6Al-4V orthodontic mini-screws coated with calcium phosphate on the TiO 2 nanotube layer

Byeon SM, Kim HJ, Lee MH, Bae TS

Objective: This study evaluated the effect of cyclic pre-calcification treatment on the improvement of bioactivity and osseointegration of Ti-6Al-4V miniscrews. Methods: The experimental groups were: an untreated group (UT), an...
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Perioperative stress prolong post-surgical pain via miR-339-5p targeting oprm1 in the amygdala

Zhu Y, Sun M, Liu P, Shao W, Xiong M, Xu B

Background: The decreased expression of mu-opioid receptors (MOR) in the amygdala may be a key molecular in chronic post-surgical pain (CPSP). It is known that miR-339-5p expression in the amygdala...
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Impact of polystyrene microplastic exposure on lipid profile and oxidative stress status of male and female Wistar rats

Nnoruka UC, Okonkwo CJ, Ilechukwu I, Okonkwo CJ, Belonwu DC

Microplastics (MPs) are currently global environmental pollutants, and their associated health risks cannot be ignored. However, research on MP toxicity in mammals is limited. We investigated the effects of polystyrene...
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Anti-stress Effect of Octopus Cephalotocin in Rats

Kim YJ, Jo S, Jung SH, Woo DH

  • KMID: 2532836
  • Exp Neurobiol.
  • 2022 Aug;31(4):260-269.
  • doi: 10.5607/en22010
Cephalotocin is a bioactivity-regulating peptide expressed in octopus (Octopus vulgaris). The peptide sequence of cephalotocin is very similar to the peptide sequence of mammalian vasopressin, and cephalotocin has been proposed...
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Enhanced Bone Regeneration by Bone Morphogenetic Protein-2 after Pretreatment with Low-Intensity Pulsed Ultrasound in Distraction Osteogenesis

Han JJ, Yang HJ, Hwang SJ

BACKGROUND: Bone morphogenetic protein 2 (BMP-2) and low-intensity pulsed ultrasound (LIPUS) have been used to enhance bone healing in distraction osteogenesis (DO). The aim of this study was to assess...
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Ameliorative effect of Abeliophyllum distichum Nakai on benign prostatic hyperplasia in vitro and in vivo

Choi YJ, Fan M, Tang Y, Moon S, Lee SH, Lee B, Bae SM, Lee SM, Kim EK

BACKGROUND/OBJECTIVES: Benign prostatic hyperplasia (BPH) is the most common prostate disease and one of the most common chronic diseases caused by aging in men. On the other hand, there has...
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The Role of Alginate Hydrogels as a Potential Treatment Modality for Spinal Cord Injury: A Comprehensive Review of the Literature

Jarrah R, Sammak SE, Onyedimma C, Ghaith AK, Moinuddin F, Bhandarkar AR, Siddiqui A, Madigan N, Bydon M

Objective: To comprehensively characterize the utilization of alginate hydrogels as an alternative treatment modality for spinal cord injury (SCI). Methods: An extensive review of the published literature on studies using alginate...
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Comparative Morphological Study on Parotid and Submandibular Salivary Glands in Ovariectomized Rats

Jeong MJ, Lee MH, Lim DS, Jeong M, Jeong SJ

Background: Estrogen deficiency affects the structure and function of the salivary glands in women, leading to a decrease in salivary secretion and a change in the composition of saliva. Previous...
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Chronic toxic effects of polystyrene microplastics on reproductive parameters of male rats

Ilechukwu I, Ehigiator BE, Ben IO, Okonkwo CJ, Olorunfemi OS, Modo UE, Ilechukwu CE, Ohagwa NJ

Microplastics have become a significant environmental concern. However, information on toxicity of microplastics in terrestrial organisms is limited. In this study, the chronic toxic effects of polystyrene microplastics (PS-MPs) on...
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Establishment of a novel experimental model of infected anal fistula in rat

Zhao M, Wang A, Zhang L, Yu H

Refractory Crohn’s-like enterocutaneous fistula indicates the aggressive manifestation and lead to poor prognosis of patients. The development of multidisciplinary strategies for fistula administration largely subjects to the deficiency of animal...
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Assessment of Bacterial Communities Within the Biofilm of Bladder Calculi in the Neurogenic Bladder Rat Model Following Spinal Cord Injury

Lee JW, Lee SS, Yang SH, Choe HS

Purpose: To develop a rat model of bladder calculi in the neurogenic bladder following spinal cord injury (SCI) and assess bacterial communities within the biofilm of bladder calculi using denaturing...
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Peripheral Neuropathy Phenotyping in Rat Models of Type 2 Diabetes Mellitus: Evaluating Uptake of the Neurodiab Guidelines and Identifying Future Directions

Hossain MJ, Kendig MD, Letton ME, Morris MJ, Arnold R

Diabetic peripheral neuropathy (DPN) affects over half of type 2 diabetes mellitus (T2DM) patients, with an urgent need for effective pharmacotherapies. While many rat and mouse models of T2DM exist,...
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Interleukin 13 on Microglia is Neurotoxic in Lipopolysaccharide-injected Striatum in vivo

Hong AR, Jang JG, Chung YC, Won SY, Jin BK

To explore the potential function of interleukin-13 (IL-13), lipopolysaccharide (LPS) or PBS as a control was unilaterally microinjected into striatum of rat brain. Seven days after LPS injection, there was...
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Pharmacological interactions between intrathecal pregabalin plus tianeptine or clopidogrel in a rat model of neuropathic pain

Lee HG, Kim YO, Choi JI, Han XH, Shin YU, Yoon MH

Background: There is still unmet need in treating neuropathic pain and increasing awareness regarding the use of drug combinations to increase the effectiveness of treatment and reduce adverse effects in...
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The role of basolateral amygdala orexin 1 receptors on the modulation of pain and psychosocial deficits in nitroglycerin-induced migraine model in adult male rats

Askari-Zahabi K, Abbasnejad M, Kooshki R, Raoof M, Esmaeili-Mahani S, Pourrahimi AM, Zamyad M

Background: Migraine headaches have been associated with sensory hyperactivity and anomalies in social/emotional responses. The main objective of this study was to evaluate the potential involvement of orexin 1 receptors...
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Fecal Microbial Enterotypes Differentially Respond to a High-fat Diet Based on Sex in Fischer-344 Rats

Choi SI, Kim N, Nam RH, Park JH, Nho H, Yu JE, Song CH, Lee SM, Lee DH

The gut microbiota interacts with the host gut environment, which is influenced by such factors as sex, age, and host diet. These factors induce changes in the microbial composition. The...
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