Ann Dermatol.
2013 May;25(2):135-144. 10.5021/ad.2013.25.2.135.
Insights into the Transforming Growth Factor-beta Signaling Pathway in Cutaneous Melanoma
- Affiliations
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- 1Institut Curie, Team "TGF-beta and Oncogenesis", Equipe Labellisee Ligue Contre le Cancer, Orsay, France. alain.mauviel@curie.fr
- 2INSERM U1021 Orsay, France.
- 3CNRS UMR 3347, Orsay, France.
- KMID: 2171779
- DOI: http://doi.org/10.5021/ad.2013.25.2.135
Abstract
- Transforming growth factor-beta (TGF-beta) is a pleiotropic growth factor with broad tissue distribution that plays critical roles during embryonic development, normal tissue homeostasis, and cancer. While its cytostatic activity on normal epithelial cells initially defined TGF-beta signaling as a tumor suppressor pathway, there is ample evidence indicating that TGF-beta is a potent pro-tumorigenic agent, acting via autocrine and paracrine mechanisms to promote peri-tumoral angiogenesis, together with tumor cell migration, immune escape, and dissemination to metastatic sites. This review summarizes the current knowledge on the implication of TGF-beta signaling in melanoma.
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